SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h8l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 12 ALA A 214
TYR A 189
TYR A 201
ASP A 207
SER A 204
 None
 1.45A 1dy4A-1h8lA:
undetectable		 1dy4A-1h8lA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		4 / 7 GLU A 268
LEU A 169
MET A 116
ILE A  70
 None
 1.11A 1tuvA-1h8lA:
undetectable		 1tuvA-1h8lA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		4 / 8 PHE A  11
GLU A 289
GLN A   7
TYR A  90
 None
 1.32A 2aoxA-1h8lA:
undetectable		 2aoxA-1h8lA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		3 / 3 HIS A  74
HIS A 181
MET A  73
 ZN  A 999 ( 3.1A)
ZN  A 999 ( 3.1A)
None
 0.90A 3mihA-1h8lA:
0.0		 3mihA-1h8lA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		3 / 3 GLU A 237
TRP A 249
LYS A 231
 None
 1.47A 4k7aA-1h8lA:
0.0		 4k7aA-1h8lA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 12 ASN A 179
ILE A  70
ASP A 193
GLY A 254
ASN A 137
 None
 1.15A 4o1eA-1h8lA:
undetectable		 4o1eA-1h8lA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 11 HIS A 181
GLU A 272
GLN A 257
ASP A 258
ASP A 149
 ZN  A 999 ( 3.1A)
GEM  A 801 (-3.0A)
None
None
None
 1.22A 4qc6A-1h8lA:
0.0		 4qc6A-1h8lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 12 HIS A 181
GLU A 272
GLN A 257
ASP A 258
ASP A 149
 ZN  A 999 ( 3.1A)
GEM  A 801 (-3.0A)
None
None
None
 1.23A 4qc6B-1h8lA:
0.0		 4qc6B-1h8lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 10 LEU A 180
LEU A 273
GLY A  80
ASN A  86
ILE A 271
 None
 1.01A 4xj7C-1h8lA:
undetectable
4xj7D-1h8lA:
undetectable		 4xj7C-1h8lA:
22.80
4xj7D-1h8lA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		4 / 5 ARG A  81
GLY A  80
GLU A  82
SER A 177
 None
 1.17A 4z3oA-1h8lA:
3.7
4z3oB-1h8lA:
3.9		 4z3oA-1h8lA:
19.61
4z3oB-1h8lA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		3 / 3 ASN A 263
ASP A 149
GLY A 254
 None
 0.62A 5fctB-1h8lA:
0.0		 5fctB-1h8lA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		3 / 3 PRO A  57
ILE A  70
SER A  32
 None
 0.79A 5fsaA-1h8lA:
0.0		 5fsaA-1h8lA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		4 / 5 SER A 202
ASN A 144
GLN A 257
ASP A 142
 None
GEM  A 801 (-4.0A)
None
None
 1.31A 5kpcA-1h8lA:
0.2		 5kpcA-1h8lA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		4 / 8 TRP A 168
THR A 171
CYH A 266
LEU A 169
 None
 1.37A 5kxiA-1h8lA:
0.0
5kxiB-1h8lA:
undetectable		 5kxiA-1h8lA:
19.76
5kxiB-1h8lA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		3 / 3 LEU A 213
ALA A 214
LEU A 176
 None
 0.45A 5uunB-1h8lA:
undetectable		 5uunB-1h8lA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 12 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0B-1h8lA:
undetectable		 6ew0B-1h8lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 12 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0D-1h8lA:
undetectable		 6ew0D-1h8lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 12 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0F-1h8lA:
undetectable		 6ew0F-1h8lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 12 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0G-1h8lA:
undetectable		 6ew0G-1h8lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 12 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0H-1h8lA:
undetectable		 6ew0H-1h8lA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 1h8l CARBOXYPEPTIDASE
GP180 RESIDUES
503-882
(Lophonetta
specularioides) 		5 / 12 VAL A 368
ASP A 369
LEU A 176
LEU A 213
GLN A 297
 None
 1.12A 6ew0I-1h8lA:
undetectable		 6ew0I-1h8lA:
11.32