SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1h8s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AJV_L_COCL501_1 (ANTIBODY 7A1 FAB')	1h8s	MUTANT AL2 6E7P9G (Mus musculus)	4 / 7	ALA A 37 TYR A 39 TYR A 97 PHE A 101	None None AIC A1000 (-4.8A) None	1.21A	2ajvH-1h8sA: 13.8 2ajvL-1h8sA: 20.0	2ajvH-1h8sA: 24.14 2ajvL-1h8sA: 37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3LS4_H_TCIH220_2 (HEAVY CHAIN OF ANTIBODY FAB FRAGMENT LIGHT CHAIN OF ANTIBODY FAB FRAGMENT)	1h8s	MUTANT AL2 6E7P9G (Mus musculus)	4 / 5	TYR A 39 GLN A 92 LEU A 99 PHE A 101	None AIC A1000 (-3.3A) AIC A1000 (-4.5A) None	0.50A	3ls4L-1h8sA: 21.0	3ls4L-1h8sA: 39.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1h8s	MUTANT AL2 6E7P9G (Mus musculus)	4 / 6	GLN A 40 TYR A 89 GLN A 9 ILE A 24	None	1.30A	3peoG-1h8sA: 0.0	3peoG-1h8sA: 23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QN9_B_DXCB610_0 (N-ACYL-PHOSPHATIDYLE THANOLAMINE-HYDROLYZ ING PHOSPHOLIPASE D)	1h8s	MUTANT AL2 6E7P9G (Mus musculus)	3 / 3	GLY A 173 PRO A 172 ALA A 223	None	0.50A	4qn9B-1h8sA: undetectable	4qn9B-1h8sA: 17.99

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2AJV_L_COCL501_1","ANTIBODY 7A1 FAB';ANTIBODY 7A1 FAB'","1h8s","MUTANT AL2 6E7P9G","Mus musculus",4,"ALA A  37;TYR A  39;TYR A  97;PHE A 101","None;None;AIC A1000 (-4.8A);None","1.21A","2ajvH-1h8sA:13.8;2ajvL-1h8sA:20.0","2ajvH-1h8sA:24.14;2ajvL-1h8sA:37.40"],["3LS4_H_TCIH220_2","HEAVY CHAIN OF ANTIBODY FAB FRAGMENT;LIGHT CHAIN OF ANTIBODY FAB FRAGMENT","1h8s","MUTANT AL2 6E7P9G","Mus musculus",4,"TYR A  39;GLN A  92;LEU A  99;PHE A 101","None;AIC A1000 (-3.3A);AIC A1000 (-4.5A);None","0.50A","3ls4L-1h8sA:21.0","3ls4L-1h8sA:39.69"],["3PEO_F_CU9F301_2","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","1h8s","MUTANT AL2 6E7P9G","Mus musculus",4,"GLN A  40;TYR A  89;GLN A   9;ILE A  24","None","1.30A","3peoG-1h8sA:0.0","3peoG-1h8sA:23.25"],["4QN9_B_DXCB610_0","N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D","1h8s","MUTANT AL2 6E7P9G","Mus musculus",3,"GLY A 173;PRO A 172;ALA A 223","None","0.50A","4qn9B-1h8sA:undetectable","4qn9B-1h8sA:17.99"]]