SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ha5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		4 / 7 LEU A1024
TYR A1100
GLY A1080
TYR A1025
 None
 1.00A 1lweA-1ha5A:
2.1		 1lweA-1ha5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		5 / 8 LEU A1129
VAL A1149
LEU A1153
VAL A1216
LEU A1218
 None
 1.38A 3kp6A-1ha5A:
undetectable
3kp6B-1ha5A:
undetectable		 3kp6A-1ha5A:
20.27
3kp6B-1ha5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		5 / 12 LEU A1058
VAL A1103
TYR A1100
GLY A1102
PRO A1029
 None
 1.20A 3mecA-1ha5A:
undetectable		 3mecA-1ha5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		3 / 3 GLU A1061
TYR A1100
SER A1195
 None
 1.00A 4at0A-1ha5A:
undetectable		 4at0A-1ha5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		4 / 8 ILE A1123
VAL A1216
LEU A1153
THR A1154
 None
 0.73A 5og9A-1ha5A:
undetectable		 5og9A-1ha5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		4 / 6 ILE A1078
ILE A1200
LEU A1198
PHE A1186
 None
 0.89A 5vkqA-1ha5A:
0.0
5vkqB-1ha5A:
0.0		 5vkqA-1ha5A:
8.49
5vkqB-1ha5A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		4 / 6 ILE A1078
ILE A1200
LEU A1198
PHE A1186
 None
 0.86A 5vkqB-1ha5A:
0.0
5vkqC-1ha5A:
0.0		 5vkqB-1ha5A:
8.49
5vkqC-1ha5A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		4 / 6 ILE A1078
ILE A1200
LEU A1198
PHE A1186
 None
 0.87A 5vkqC-1ha5A:
0.0
5vkqD-1ha5A:
0.0		 5vkqC-1ha5A:
8.49
5vkqD-1ha5A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		4 / 6 PHE A1186
ILE A1078
ILE A1200
LEU A1198
 None
 0.85A 5vkqA-1ha5A:
0.0
5vkqD-1ha5A:
undetectable		 5vkqA-1ha5A:
8.49
5vkqD-1ha5A:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		5 / 9 ASN A1136
ILE A1133
ILE A1117
VAL A1149
ILE A1214
 None
 1.34A 6hloA-1ha5A:
undetectable		 6hloA-1ha5A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1ha5 STREPTOCOCCAL
PYOGENIC EXOTOXIN A1
(Streptococcus
pyogenes) 		4 / 5 GLY A1170
LEU A1218
SER A1165
TYR A1160
 None
 1.17A 6ji6A-1ha5A:
undetectable		 6ji6A-1ha5A:
23.39