SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1har'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 LYS A 104
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.94A 1fk9A-1harA:
26.8
1fk9A-1harA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 11 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.48A 1fkpA-1harA:
13.2
1fkpA-1harA:
93.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.53A 1lw0A-1harA:
26.4
1lw0A-1harA:
43.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 11 LYS A 104
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
1.00A 1lwcA-1harA:
24.3
1lwcA-1harA:
93.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 11 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.55A 1lwcA-1harA:
24.3
1lwcA-1harA:
93.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 VAL A 106
TYR A 181
TYR A 188
GLY A 190
None
0.50A 1lweA-1harA:
23.1
1lweA-1harA:
42.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 9 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.54A 1lwfA-1harA:
13.1
1lwfA-1harA:
42.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S1U_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.52A 1s1uA-1harA:
26.5
1s1uA-1harA:
93.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 VAL A 106
TYR A 181
TYR A 188
GLY A 190
None
0.51A 1s1xA-1harA:
12.0
1s1xA-1harA:
93.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 1v54A-1harA:
undetectable
1v54J-1harA:
0.0
1v54A-1harA:
18.00
1v54J-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.75A 1v54N-1harA:
undetectable
1v54W-1harA:
0.1
1v54N-1harA:
18.00
1v54W-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.66A 1v55A-1harA:
undetectable
1v55J-1harA:
0.1
1v55A-1harA:
18.00
1v55J-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.70A 1v55N-1harA:
undetectable
1v55W-1harA:
0.1
1v55N-1harA:
18.00
1v55W-1harA:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 9 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.50A 1vrtA-1harA:
26.8
1vrtA-1harA:
94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.71A 2dyrA-1harA:
undetectable
2dyrJ-1harA:
0.1
2dyrA-1harA:
18.00
2dyrJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.74A 2dyrN-1harA:
undetectable
2dyrW-1harA:
0.0
2dyrN-1harA:
18.00
2dyrW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 2dysA-1harA:
undetectable
2dysJ-1harA:
0.1
2dysA-1harA:
18.00
2dysJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.74A 2dysN-1harA:
undetectable
2dysW-1harA:
0.1
2dysN-1harA:
18.00
2dysW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.69A 2eijA-1harA:
undetectable
2eijJ-1harA:
0.1
2eijA-1harA:
18.00
2eijJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.68A 2eijN-1harA:
undetectable
2eijW-1harA:
0.1
2eijN-1harA:
18.00
2eijW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.67A 2eikA-1harA:
undetectable
2eikJ-1harA:
0.0
2eikA-1harA:
18.00
2eikJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.70A 2eikN-1harA:
undetectable
2eikW-1harA:
0.0
2eikN-1harA:
18.00
2eikW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.71A 2eilA-1harA:
undetectable
2eilJ-1harA:
0.0
2eilA-1harA:
18.00
2eilJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 2eilN-1harA:
undetectable
2eilW-1harA:
0.0
2eilN-1harA:
18.00
2eilW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.79A 2einA-1harA:
undetectable
2einJ-1harA:
0.1
2einA-1harA:
18.00
2einJ-1harA:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.50A 2hndA-1harA:
26.7
2hndA-1harA:
92.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 LYS A 104
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
1.00A 2hnyA-1harA:
26.6
2hnyA-1harA:
92.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.53A 2hnyA-1harA:
26.6
2hnyA-1harA:
92.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 12 ALA A 158
LEU A 149
PHE A 160
ILE A   5
LEU A 214
None
1.15A 2oipD-1harA:
undetectable
2oipD-1harA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.77A 2zxwA-1harA:
undetectable
2zxwJ-1harA:
0.0
2zxwA-1harA:
18.00
2zxwJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 3abkA-1harA:
undetectable
3abkJ-1harA:
0.1
3abkA-1harA:
18.00
3abkJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.75A 3ablA-1harA:
undetectable
3ablJ-1harA:
0.0
3ablA-1harA:
18.00
3ablJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.71A 3ablN-1harA:
undetectable
3ablW-1harA:
0.0
3ablN-1harA:
18.00
3ablW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 3abmA-1harA:
undetectable
3abmJ-1harA:
0.0
3abmA-1harA:
18.00
3abmJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 3abmN-1harA:
undetectable
3abmW-1harA:
0.0
3abmN-1harA:
18.00
3abmW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 3ag3A-1harA:
undetectable
3ag3J-1harA:
0.0
3ag3A-1harA:
18.00
3ag3J-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.79A 3ag3N-1harA:
undetectable
3ag3W-1harA:
0.1
3ag3N-1harA:
18.00
3ag3W-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.73A 3asnA-1harA:
undetectable
3asnJ-1harA:
0.1
3asnA-1harA:
18.00
3asnJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.74A 3asnN-1harA:
undetectable
3asnW-1harA:
0.1
3asnN-1harA:
18.00
3asnW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 3asoA-1harA:
undetectable
3asoJ-1harA:
0.1
3asoA-1harA:
18.00
3asoJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.71A 3asoN-1harA:
undetectable
3asoW-1harA:
0.0
3asoN-1harA:
18.00
3asoW-1harA:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HVT_A_NVPA557_1
(HIV-1 REVERSE
TRANSCRIPTASE
(SUBUNIT P66))
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 9 LYS A 104
VAL A 106
TYR A 181
TYR A 188
GLY A 190
None
1.07A 3hvtA-1harA:
24.3
3hvtA-1harA:
94.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 9 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.62A 3lp0A-1harA:
27.0
3lp0A-1harA:
93.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.65A 3lp1A-1harA:
27.5
3lp1A-1harA:
93.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 12 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.68A 3mecA-1harA:
13.0
3mecA-1harA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 12 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.68A 3medA-1harA:
27.7
3medB-1harA:
10.3
3medA-1harA:
93.98
3medB-1harA:
93.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 LYS A 104
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.97A 3qipA-1harA:
12.6
3qipA-1harA:
94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.51A 3qipA-1harA:
12.6
3qipA-1harA:
94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
3 / 3 ASN A  54
ALA A 129
ARG A 143
None
0.88A 3tj7C-1harA:
0.0
3tj7D-1harA:
0.0
3tj7C-1harA:
19.57
3tj7D-1harA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 168
LEU A 205
ILE A 202
THR A 216
None
0.90A 4do3B-1harA:
0.9
4do3B-1harA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A  34
CYH A  38
TYR A 144
PRO A 133
None
1.20A 4j7uD-1harA:
undetectable
4j7uD-1harA:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 VAL A 106
VAL A 179
TYR A 181
TYR A 188
None
0.57A 4puoC-1harA:
21.4
4puoC-1harA:
94.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 VAL A 106
VAL A 179
TYR A 181
TYR A 188
None
0.54A 4pwdA-1harA:
21.6
4pwdA-1harA:
94.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 VAL A 106
VAL A 179
TYR A 181
TYR A 188
None
0.59A 4pwdC-1harA:
12.4
4pwdC-1harA:
94.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.70A 5b1aA-1harA:
undetectable
5b1aJ-1harA:
0.1
5b1aA-1harA:
18.00
5b1aJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 5b1bA-1harA:
undetectable
5b1bJ-1harA:
0.1
5b1bA-1harA:
18.00
5b1bJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.73A 5b3sA-1harA:
undetectable
5b3sJ-1harA:
0.1
5b3sA-1harA:
18.00
5b3sJ-1harA:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
6 / 11 LYS A 104
VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.88A 5hbmA-1harA:
27.5
5hbmA-1harA:
94.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.73A 5iy5A-1harA:
undetectable
5iy5J-1harA:
0.1
5iy5A-1harA:
18.00
5iy5J-1harA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
HIS A 198
LEU A 168
ILE A 178
None
0.95A 5v0vA-1harA:
0.3
5v0vA-1harA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 6 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.76A 5x1fA-1harA:
undetectable
5x1fJ-1harA:
0.2
5x1fA-1harA:
18.00
5x1fJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.95A 5xdqN-1harA:
undetectable
5xdqW-1harA:
0.0
5xdqN-1harA:
18.00
5xdqW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.75A 5xdxA-1harA:
undetectable
5xdxJ-1harA:
0.1
5xdxA-1harA:
18.00
5xdxJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 5xdxN-1harA:
undetectable
5xdxW-1harA:
0.0
5xdxN-1harA:
18.00
5xdxW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.73A 5zcoA-1harA:
undetectable
5zcoJ-1harA:
0.1
5zcoA-1harA:
18.00
5zcoJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 5zcpA-1harA:
undetectable
5zcpJ-1harA:
0.1
5zcpA-1harA:
18.00
5zcpJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.74A 5zcpN-1harA:
undetectable
5zcpW-1harA:
0.1
5zcpN-1harA:
18.00
5zcpW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.70A 5zcqA-1harA:
undetectable
5zcqJ-1harA:
0.1
5zcqA-1harA:
18.00
5zcqJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 8 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.72A 5zcqN-1harA:
undetectable
5zcqW-1harA:
0.1
5zcqN-1harA:
18.00
5zcqW-1harA:
13.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 LYS A 104
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
0.87A 6bsgA-1harA:
26.1
6bsgA-1harA:
91.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
5 / 10 LYS A 104
VAL A 179
TYR A 181
TYR A 188
GLY A 190
None
1.10A 6bsiA-1harA:
24.0
6bsiA-1harA:
91.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.87A 6nmfA-1harA:
undetectable
6nmfJ-1harA:
0.1
6nmfA-1harA:
18.00
6nmfJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus
1)
4 / 7 LEU A 109
MET A 164
THR A 165
LEU A 168
None
0.96A 6nmpA-1harA:
undetectable
6nmpJ-1harA:
0.1
6nmpA-1harA:
18.00
6nmpJ-1harA:
13.37