SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		3 / 3 MET A  80
LEU A  83
SER A  84
 None
HEM  A 142 (-4.6A)
None
 0.54A 1ee2A-1hbrA:
undetectable		 1ee2A-1hbrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		4 / 7 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 (-3.8A)
HEM  A 142 (-4.8A)
HEM  A 142 ( 4.1A)
HEM  A 142 (-3.3A)
 0.91A 1lh6A-1hbrA:
14.4		 1lh6A-1hbrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		3 / 3 LEU A 129
VAL A 132
LEU A 136
 None
 0.50A 1mz9B-1hbrA:
undetectable		 1mz9B-1hbrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		5 / 10 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
 None
 1.11A 2bxeA-1hbrA:
2.1		 2bxeA-1hbrA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		5 / 11 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
 None
 1.13A 2bxeB-1hbrA:
undetectable		 2bxeB-1hbrA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		5 / 12 PHE A 128
LEU A 136
HIS A  87
ALA A  79
ALA A  65
 None
None
HEM  A 142 (-3.3A)
None
HEM  A 142 ( 3.9A)
 0.90A 2bxpA-1hbrA:
undetectable		 2bxpA-1hbrA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		4 / 5 PHE A 128
PHE A 125
LEU A 109
PHE A  24
 None
 1.31A 2y69P-1hbrA:
0.8
2y69W-1hbrA:
0.0		 2y69P-1hbrA:
18.99
2y69W-1hbrA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		4 / 8 LEU A  63
VAL A  62
VAL A 132
LEU A 129
 None
HEM  A 142 ( 4.1A)
None
None
 0.87A 2zujA-1hbrA:
undetectable		 2zujA-1hbrA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		5 / 9 GLN A  21
ALA A  18
LEU A 129
VAL A 132
ILE A 105
 None
 1.26A 3claA-1hbrA:
undetectable		 3claA-1hbrA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		5 / 12 VAL A 132
LEU A  76
LEU A 136
GLY A  67
ALA A  65
 None
None
None
None
HEM  A 142 ( 3.9A)
 1.12A 3rr3C-1hbrA:
undetectable		 3rr3C-1hbrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		5 / 12 VAL A 132
LEU A  76
LEU A 136
GLY A  67
ALA A  65
 None
None
None
None
HEM  A 142 ( 3.9A)
 1.12A 3rr3D-1hbrA:
undetectable		 3rr3D-1hbrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		3 / 3 PHE A  46
SER A  52
GLN A  54
 HEM  A 142 (-4.8A)
None
None
 0.80A 3smtA-1hbrA:
undetectable		 3smtA-1hbrA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		4 / 4 LEU A  76
SER A 133
LEU A  66
LEU A   2
 None
HEM  A 142 ( 4.4A)
None
None
 1.02A 4n09A-1hbrA:
undetectable		 4n09A-1hbrA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		5 / 12 VAL A 132
LEU A  76
LEU A 136
GLY A  67
ALA A  65
 None
None
None
None
HEM  A 142 ( 3.9A)
 1.10A 5jvzA-1hbrA:
0.8		 5jvzA-1hbrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		5 / 12 VAL A 132
LEU A  76
LEU A 136
GLY A  67
ALA A  65
 None
None
None
None
HEM  A 142 ( 3.9A)
 1.13A 5jvzB-1hbrA:
undetectable		 5jvzB-1hbrA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		4 / 5 PHE A 128
PHE A 125
LEU A 109
PHE A  24
 None
 1.33A 5xdqC-1hbrA:
0.8
5xdqJ-1hbrA:
0.0		 5xdqC-1hbrA:
18.99
5xdqJ-1hbrA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1hbr PROTEIN (HEMOGLOBIN
D)
(Gallus
gallus) 		4 / 5 PHE A 128
PHE A 125
LEU A 109
PHE A  24
 None
 1.34A 5xdqP-1hbrA:
0.8
5xdqW-1hbrA:
0.0		 5xdqP-1hbrA:
18.99
5xdqW-1hbrA:
17.73