SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1hci ALPHA-ACTININ 2
(Homo
sapiens) 		5 / 12 GLY A 534
ALA A 535
ASP A 538
VAL A 618
VAL A 614
 None
 0.90A 1k6cB-1hciA:
undetectable		 1k6cB-1hciA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1hci ALPHA-ACTININ 2
(Homo
sapiens) 		5 / 8 ILE A 591
LEU A 510
ILE A 514
GLU A 581
ILE A 586
 None
 1.14A 1linA-1hciA:
undetectable		 1linA-1hciA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1hci ALPHA-ACTININ 2
(Homo
sapiens) 		3 / 3 LEU A 434
VAL A 437
LEU A 441
 None
 0.52A 1mz9B-1hciA:
undetectable		 1mz9B-1hciA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1hci ALPHA-ACTININ 2
(Homo
sapiens) 		4 / 8 PHE A 543
LEU A 554
ILE A 555
HIS A 558
 None
 0.94A 2azxA-1hciA:
undetectable		 2azxA-1hciA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 1hci ALPHA-ACTININ 2
(Homo
sapiens) 		4 / 6 LEU A 289
LEU A 341
PRO A 362
VAL A 368
 None
 1.19A 2dqyC-1hciA:
undetectable		 2dqyC-1hciA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 1hci ALPHA-ACTININ 2
(Homo
sapiens) 		5 / 12 GLY A 373
LEU A 294
ARG A 298
MET A 361
LEU A 341
 None
 1.16A 3h52D-1hciA:
undetectable		 3h52D-1hciA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 1hci ALPHA-ACTININ 2
(Homo
sapiens) 		5 / 12 LEU A 396
LEU A 399
LEU A 402
ALA A 403
ALA A 476
 None
 0.84A 4fn9A-1hciA:
undetectable		 4fn9A-1hciA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)		 1hci ALPHA-ACTININ 2
(Homo
sapiens) 		4 / 8 LEU A 726
GLY A 723
GLU A 725
GLU A 718
 None
 0.76A 4rjdA-1hciA:
undetectable
4rjdB-1hciA:
undetectable		 4rjdA-1hciA:
9.83
4rjdB-1hciA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1hci ALPHA-ACTININ 2
(Homo
sapiens) 		5 / 12 VAL A 614
LEU A 565
PHE A 561
GLY A 534
PHE A 528
 None
 1.13A 6drzA-1hciA:
2.3		 6drzA-1hciA:
20.77