SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 4 SER A 180
GLU A 456
SER A 397
ASP A 245
 None
CA  A1495 ( 4.3A)
None
None
 1.08A 1h1dA-1hcuA:
0.0		 1h1dA-1hcuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 8 PRO A 352
GLY A 351
PHE A 375
THR A 344
 None
 0.87A 1h4oB-1hcuA:
undetectable		 1h4oB-1hcuA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J78_B_VDYB500_1
(VITAMIN D BINDING
PROTEIN)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 10 GLU A 456
PHE A  99
TYR A 250
LYS A 253
SER A 111
 CA  A1495 ( 4.3A)
None
None
None
None
 1.26A 1j78B-1hcuA:
0.1		 1j78B-1hcuA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 8 GLU A 393
SER A 451
ASP A  39
GLU A 456
 None
None
None
CA  A1495 ( 4.3A)
 1.18A 1knyA-1hcuA:
0.0
1knyB-1hcuA:
1.1		 1knyA-1hcuA:
19.68
1knyB-1hcuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 7 ASP A 114
GLY A 108
ILE A  59
ALA A  65
ILE A  66
 None
 0.92A 1n49A-1hcuA:
undetectable		 1n49A-1hcuA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 6 ASP A 114
GLY A 108
ILE A  59
ILE A  66
 None
 0.83A 1n49D-1hcuA:
undetectable		 1n49D-1hcuA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 SER A  96
PHE A 161
LEU A 181
PHE A 148
ALA A 141
 None
 1.44A 1q23D-1hcuA:
undetectable
1q23E-1hcuA:
0.0		 1q23D-1hcuA:
16.07
1q23E-1hcuA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 4 LYS A 409
LEU A 413
LEU A 398
SER A 397
 None
 1.49A 1tt6A-1hcuA:
0.0		 1tt6A-1hcuA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 5 SER A 180
GLU A 456
SER A 397
ASP A 245
 None
CA  A1495 ( 4.3A)
None
None
 1.09A 1vidA-1hcuA:
0.0		 1vidA-1hcuA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 8 SER A 246
LEU A 208
LEU A 106
PHE A 148
 None
 0.97A 1wrlC-1hcuA:
undetectable
1wrlD-1hcuA:
undetectable		 1wrlC-1hcuA:
9.64
1wrlD-1hcuA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 GLY A 313
GLY A 312
SER A 397
LEU A 293
SER A 294
 None
 0.91A 1ya4A-1hcuA:
undetectable		 1ya4A-1hcuA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A7Q_A_CFBA328_1
(DEOXYCYTIDINE KINASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 GLU A 486
TYR A 250
ARG A 104
PHE A  99
GLU A 249
 None
None
None
None
CA  A1495 ( 4.2A)
 1.49A 2a7qA-1hcuA:
0.0		 2a7qA-1hcuA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B82_A_ADNA1001_1
(CLASS B ACID
PHOSPHATASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 10 LYS A 203
LEU A 200
TRP A 185
GLY A 143
THR A 150
 None
 1.47A 2b82A-1hcuA:
undetectable		 2b82A-1hcuA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 LEU A 115
ILE A  77
SER A 122
ASP A  63
PHE A 481
 None
 1.23A 2ejtA-1hcuA:
undetectable		 2ejtA-1hcuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 PHE A 452
ALA A 420
ALA A 417
GLY A 351
GLY A 349
 None
 1.03A 2igtA-1hcuA:
undetectable		 2igtA-1hcuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 PHE A 452
ALA A 420
ALA A 417
GLY A 351
GLY A 349
 None
 1.05A 2igtB-1hcuA:
undetectable		 2igtB-1hcuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 4 ALA A 461
TYR A 460
ALA A 414
TYR A 399
 None
 1.21A 2wlkA-1hcuA:
0.0
2wlkB-1hcuA:
0.0		 2wlkA-1hcuA:
19.88
2wlkB-1hcuA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 8 SER A 446
GLY A 351
ILE A 421
ALA A 417
 None
 0.95A 3aodA-1hcuA:
0.0		 3aodA-1hcuA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 GLY A 313
GLY A 332
SER A 338
HIS A 307
SER A 397
 None
 1.12A 3dlcA-1hcuA:
undetectable		 3dlcA-1hcuA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 10 ASP A 114
GLY A 108
ILE A  59
ALA A  65
ILE A  66
 None
 0.95A 3ekwA-1hcuA:
undetectable		 3ekwA-1hcuA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 4 LEU A 181
ALA A 147
VAL A 159
PRO A 157
 None
 1.03A 3gv1B-1hcuA:
undetectable		 3gv1B-1hcuA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 6 SER A 305
PHE A 292
TYR A 339
PRO A 284
 None
 1.20A 3jqaA-1hcuA:
undetectable		 3jqaA-1hcuA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 6 SER A 305
PHE A 292
TYR A 339
PRO A 284
 None
 1.15A 3jqaC-1hcuA:
undetectable		 3jqaC-1hcuA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 6 SER A 305
PHE A 292
TYR A 339
PRO A 284
 None
 1.18A 3jqaD-1hcuA:
undetectable		 3jqaD-1hcuA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 5 ARG A 104
ASP A 448
ASP A  39
ASP A  48
 None
 1.43A 3naiA-1hcuA:
0.0		 3naiA-1hcuA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVY_B_TOYB201_1
(AMINOGLYCOSIDE
N(6')-ACETYLTRANSFER
ASE TYPE 1)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 10 GLU A 396
ARG A 104
GLU A 100
GLU A 184
GLY A 107
 CA  A1495 ( 4.9A)
None
None
None
None
 1.47A 4evyA-1hcuA:
0.0
4evyB-1hcuA:
undetectable		 4evyA-1hcuA:
15.69
4evyB-1hcuA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 ASP A  60
PHE A  99
LEU A 109
LEU A 140
HIS A 488
 None
 1.14A 4j03A-1hcuA:
undetectable		 4j03A-1hcuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		3 / 3 ARG A 104
ASP A  63
ASP A 114
 None
 0.87A 4kicB-1hcuA:
undetectable		 4kicB-1hcuA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 8 GLY A 314
GLY A 319
ILE A 321
LEU A 256
 None
 0.68A 4mwzB-1hcuA:
0.0		 4mwzB-1hcuA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 ILE A  66
GLY A 107
SER A 111
LEU A 115
LEU A 116
 None
 0.91A 4o1zA-1hcuA:
0.0		 4o1zA-1hcuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 8 LEU A 115
VAL A 130
LEU A 133
GLY A 107
 None
 0.82A 4r3aA-1hcuA:
undetectable		 4r3aA-1hcuA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 7 LEU A 106
ALA A 137
LEU A 110
ALA A 141
 None
 0.67A 4z90F-1hcuA:
1.0
4z90G-1hcuA:
1.1
4z90H-1hcuA:
1.0
4z90J-1hcuA:
1.1		 4z90F-1hcuA:
22.31
4z90G-1hcuA:
22.31
4z90H-1hcuA:
22.31
4z90J-1hcuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 GLY A 319
LEU A 251
GLY A 332
ILE A 329
GLY A 272
 None
 1.03A 5d4uC-1hcuA:
undetectable		 5d4uC-1hcuA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 GLY A 319
LEU A 251
GLY A 332
ILE A 329
GLY A 272
 None
 1.01A 5d4uD-1hcuA:
undetectable		 5d4uD-1hcuA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		3 / 3 ASP A  63
VAL A  74
LEU A 123
 None
 0.66A 5e5jB-1hcuA:
0.0		 5e5jB-1hcuA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 5 SER A 180
GLU A 456
SER A 397
ASP A 245
 None
CA  A1495 ( 4.3A)
None
None
 1.15A 5fhrA-1hcuA:
0.0		 5fhrA-1hcuA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 10 ALA A  65
ILE A  73
PHE A  23
SER A  57
GLY A  61
 None
 1.13A 5i6xA-1hcuA:
0.0		 5i6xA-1hcuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 10 THR A 342
THR A 394
SER A 397
GLY A 306
ALA A 309
 None
 1.14A 5l66K-1hcuA:
undetectable
5l66L-1hcuA:
undetectable		 5l66K-1hcuA:
19.64
5l66L-1hcuA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 10 THR A 342
THR A 394
SER A 397
GLY A 306
ALA A 309
 None
 1.14A 5l66Y-1hcuA:
undetectable
5l66Z-1hcuA:
undetectable		 5l66Y-1hcuA:
19.64
5l66Z-1hcuA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		3 / 3 TYR A 296
SER A 294
TRP A 218
 None
 1.07A 5n8jA-1hcuA:
0.0		 5n8jA-1hcuA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		5 / 12 GLY A 341
VAL A 404
GLY A 313
SER A 310
PHE A 292
 None
 1.15A 5vooF-1hcuA:
undetectable		 5vooF-1hcuA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		4 / 8 GLY A 354
ALA A 385
GLY A 306
SER A 241
 None
 0.66A 5vw9A-1hcuA:
undetectable		 5vw9A-1hcuA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1hcu ALPHA-1,2-MANNOSIDAS
E
(Trichoderma
reesei) 		3 / 3 GLY A 220
VAL A 175
MET A 244
 None
 0.59A 5ycpA-1hcuA:
0.0		 5ycpA-1hcuA:
9.18