SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hdg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 7 ASN O 313
TYR O 317
ASN O 152
TYR O 311
 NAD  O 336 (-3.9A)
NAD  O 336 (-3.5A)
None
None
 0.97A 1dssG-1hdgO:
49.0		 1dssG-1hdgO:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		6 / 7 SER O 148
THR O 150
ASN O 152
TYR O 311
ASN O 313
TYR O 317
 SO4  O 339 (-2.8A)
SO4  O 339 (-3.5A)
None
None
NAD  O 336 (-3.9A)
NAD  O 336 (-3.5A)
 0.25A 1dssG-1hdgO:
49.0		 1dssG-1hdgO:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 ASN O 313
TYR O 317
ASN O 152
TYR O 311
 NAD  O 336 (-3.9A)
NAD  O 336 (-3.5A)
None
None
 0.96A 1dssR-1hdgO:
49.0		 1dssR-1hdgO:
47.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		7 / 8 SER O 148
THR O 150
ASN O 152
HIS O 176
TYR O 311
ASN O 313
TYR O 317
 SO4  O 339 (-2.8A)
SO4  O 339 (-3.5A)
None
SO4  O 339 (-4.4A)
None
NAD  O 336 (-3.9A)
NAD  O 336 (-3.5A)
 0.31A 1dssR-1hdgO:
49.0		 1dssR-1hdgO:
47.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 ASP O 323
ILE O 271
VAL O 217
 None
 0.58A 2avvD-1hdgO:
undetectable		 2avvD-1hdgO:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 5 LEU O 329
ASN O  22
VAL O   3
ALA O   1
 None
 1.21A 2cizA-1hdgO:
0.0		 2cizA-1hdgO:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 VAL O 221
VAL O 168
ASP O 241
 None
 0.59A 2fumD-1hdgO:
undetectable		 2fumD-1hdgO:
21.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		4 / 8 ASN O 313
TYR O 317
ASN O 152
TYR O 311
 NAD  O 336 (-3.9A)
NAD  O 336 (-3.5A)
None
None
 0.99A 3dmtC-1hdgO:
46.9		 3dmtC-1hdgO:
47.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		7 / 8 SER O 148
THR O 150
ASN O 152
HIS O 176
TYR O 311
ASN O 313
TYR O 317
 SO4  O 339 (-2.8A)
SO4  O 339 (-3.5A)
None
SO4  O 339 (-4.4A)
None
NAD  O 336 (-3.9A)
NAD  O 336 (-3.5A)
 0.33A 3dmtC-1hdgO:
46.9		 3dmtC-1hdgO:
47.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 TYR O  18
GLY O  55
PRO O  54
 None
 0.69A 4qwpA-1hdgO:
0.0		 4qwpA-1hdgO:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 11 THR O 150
GLN O 182
ALA O 210
GLY O 209
ASP O 192
 SO4  O 339 (-3.5A)
None
None
SO4  O 339 (-3.8A)
None
 1.28A 5bxnV-1hdgO:
undetectable
5bxnW-1hdgO:
undetectable		 5bxnV-1hdgO:
22.13
5bxnW-1hdgO:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 THR O 151
ALA O 147
ASN O 152
 None
 0.55A 5ersA-1hdgO:
undetectable		 5ersA-1hdgO:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 ILE O 167
ALA O 262
MET O 259
VAL O 258
GLY O 272
 None
 1.25A 5igiA-1hdgO:
0.0		 5igiA-1hdgO:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 11 ILE O  93
PHE O  91
ASN O  22
ILE O  25
ALA O   1
 None
 1.06A 5lg3A-1hdgO:
0.1		 5lg3A-1hdgO:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 12 ILE O  93
PHE O  91
ASN O  22
ILE O  25
ALA O   1
 None
 1.05A 5lg3E-1hdgO:
undetectable		 5lg3E-1hdgO:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		3 / 3 THR O 207
THR O 206
ARG O 195
 None
None
SO4  O 338 (-3.8A)
 0.99A 5wm2A-1hdgO:
2.0		 5wm2A-1hdgO:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE
(Thermotoga
maritima) 		5 / 9 ASP O  67
TYR O  18
GLY O  12
SER O  95
ILE O   5
 None
 1.42A 6giqA-1hdgO:
0.0
6giqE-1hdgO:
0.0
6giqI-1hdgO:
0.0		 6giqA-1hdgO:
22.58
6giqE-1hdgO:
23.10
6giqI-1hdgO:
12.86