SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
(Odocoileus
virginianus) 		4 / 7 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 142 (-3.6A)
None
HEM  A 142 (-3.8A)
HEM  A 142 (-2.9A)
 0.87A 1lh6A-1hdsA:
13.0		 1lh6A-1hdsA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
HEMOGLOBIN S (DEOXY)
(BETA CHAIN)
(Odocoileus
virginianus) 		5 / 12 PHE B  70
PHE B 129
VAL A 107
PHE B 121
ALA B  26
 None
 1.31A 1q23A-1hdsB:
undetectable
1q23B-1hdsB:
undetectable		 1q23A-1hdsB:
20.71
1q23B-1hdsB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1hds HEMOGLOBIN S (DEOXY)
(BETA CHAIN)
(Odocoileus
virginianus) 		5 / 9 LEU B  67
LEU B 109
VAL B 136
ALA B 139
LEU B  87
 None
None
None
None
HEM  B 146 ( 4.6A)
 1.24A 1tbfA-1hdsB:
0.0		 1tbfA-1hdsB:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
(Odocoileus
virginianus) 		4 / 6 LEU A 109
HIS A 122
ASN A 126
PHE A 128
 None
 0.81A 1xf1B-1hdsA:
undetectable		 1xf1B-1hdsA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
(Odocoileus
virginianus) 		5 / 10 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
 None
 1.08A 2bxeA-1hdsA:
undetectable		 2bxeA-1hdsA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
(Odocoileus
virginianus) 		5 / 11 ALA A  69
LEU A  76
SER A  84
LEU A 136
VAL A 135
 None
 1.12A 2bxeB-1hdsA:
2.1		 2bxeB-1hdsA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1hds HEMOGLOBIN S (DEOXY)
(BETA CHAIN)
(Odocoileus
virginianus) 		4 / 8 LEU B 128
LEU B 109
VAL B  17
GLY B  15
 None
 0.97A 2po5B-1hdsB:
undetectable		 2po5B-1hdsB:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
HEMOGLOBIN S (DEOXY)
(BETA CHAIN)
(Odocoileus
virginianus) 		4 / 8 ARG A  31
HIS A 112
SER A 111
ALA B 114
 None
 1.35A 2rk8A-1hdsA:
3.2		 2rk8A-1hdsA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 1hds HEMOGLOBIN S (DEOXY)
(BETA CHAIN)
(Odocoileus
virginianus) 		4 / 7 ALA B  26
VAL B  17
VAL B 113
LEU B 109
 None
 0.75A 3o14A-1hdsB:
undetectable		 3o14A-1hdsB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
HEMOGLOBIN S (DEOXY)
(BETA CHAIN)
(Odocoileus
virginianus) 		4 / 8 VAL A  96
LEU A 100
GLN B 130
VAL B 133
 None
 0.94A 4ma7A-1hdsA:
2.5		 4ma7A-1hdsA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 1hds HEMOGLOBIN S (DEOXY)
(BETA CHAIN)
(Odocoileus
virginianus) 		4 / 5 ASP B  68
VAL B 113
GLY B  23
ALA B  26
 None
 0.91A 5hwaA-1hdsB:
undetectable		 5hwaA-1hdsB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WP1_A_BEZA403_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 1hds HEMOGLOBIN S (DEOXY)
(BETA CHAIN)
(Odocoileus
virginianus) 		4 / 4 GLY B  45
PHE B  44
ASN B  56
LYS B  58
 None
 1.14A 5wp1A-1hdsB:
undetectable		 5wp1A-1hdsB:
17.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
HEMOGLOBIN S (DEOXY)
(BETA CHAIN)
(Odocoileus
virginianus) 		5 / 8 PRO A  95
THR A 134
THR A 137
TYR A 140
TRP B  36
 None
 0.67A 5x2sI-1hdsA:
23.8
5x2sJ-1hdsA:
19.8
5x2sK-1hdsA:
23.9		 5x2sI-1hdsA:
77.30
5x2sJ-1hdsA:
41.22
5x2sK-1hdsA:
77.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1hds HEMOGLOBIN S (DEOXY)
(ALPHA CHAIN)
HEMOGLOBIN S (DEOXY)
(BETA CHAIN)
(Odocoileus
virginianus) 		5 / 8 PRO A  95
ALA A 130
THR A 134
THR A 137
TRP B  36
 None
 0.58A 5x2tI-1hdsA:
24.0
5x2tJ-1hdsA:
20.0
5x2tK-1hdsA:
24.0
5x2tL-1hdsA:
18.5		 5x2tI-1hdsA:
77.30
5x2tJ-1hdsA:
41.22
5x2tK-1hdsA:
77.30
5x2tL-1hdsA:
41.22