SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1he9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1he9 EXOENZYME S
(Pseudomonas
aeruginosa) 		5 / 5 THR A 207
LEU A 210
VAL A 213
LEU A 171
GLN A 167
 None
 1.46A 1fbmE-1he9A:
undetectable		 1fbmE-1he9A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1he9 EXOENZYME S
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 152
GLY A 158
SER A 149
LEU A 148
SER A 147
 None
 0.97A 2qmmA-1he9A:
undetectable
2qmmB-1he9A:
undetectable		 2qmmA-1he9A:
24.00
2qmmB-1he9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1he9 EXOENZYME S
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 152
ILE A 155
SER A 149
LEU A 148
SER A 147
 None
 1.01A 2qmmA-1he9A:
undetectable
2qmmB-1he9A:
undetectable		 2qmmA-1he9A:
24.00
2qmmB-1he9A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 1he9 EXOENZYME S
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 171
LEU A 181
ALA A 151
THR A 150
GLU A 122
 None
 1.27A 2v0mC-1he9A:
undetectable		 2v0mC-1he9A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1he9 EXOENZYME S
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 120
LEU A 145
LEU A 181
VAL A 213
ILE A 206
 None
 1.25A 3jw5A-1he9A:
undetectable		 3jw5A-1he9A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1he9 EXOENZYME S
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 181
MET A 112
ALA A 151
SER A 147
LEU A 148
 None
 1.44A 4m11A-1he9A:
undetectable		 4m11A-1he9A:
11.55