SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hf2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC
(Thermotoga
maritima) 		5 / 9 ALA A 134
ILE A 148
ILE A 121
ILE A 108
ILE A 132
 None
 0.92A 1hshB-1hf2A:
undetectable		 1hshB-1hf2A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC
(Thermotoga
maritima) 		4 / 6 ILE A  62
VAL A  63
VAL A 122
ILE A 148
 None
 0.79A 1uwhA-1hf2A:
undetectable		 1uwhA-1hf2A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC
(Thermotoga
maritima) 		4 / 6 ILE A  62
VAL A  63
VAL A 122
ILE A 148
 None
 0.79A 1uwhB-1hf2A:
0.3		 1uwhB-1hf2A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC
(Thermotoga
maritima) 		5 / 10 ALA A 144
ILE A 108
ILE A 121
ALA A 150
ILE A 148
 None
 1.02A 3ekwA-1hf2A:
undetectable		 3ekwA-1hf2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC
(Thermotoga
maritima) 		5 / 12 ALA A 144
ILE A 108
ILE A 121
ALA A 150
ILE A 148
 None
 0.86A 3ekwB-1hf2A:
undetectable		 3ekwB-1hf2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC
(Thermotoga
maritima) 		5 / 9 ALA A 134
ILE A 148
VAL A 160
ILE A 108
ILE A 132
 None
 0.95A 3s43A-1hf2A:
undetectable		 3s43A-1hf2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1hf2 SEPTUM
SITE-DETERMINING
PROTEIN MINC
(Thermotoga
maritima) 		4 / 5 TYR A  18
GLN A  19
GLY A  79
ILE A  49
 None
 1.35A 6debB-1hf2A:
undetectable		 6debB-1hf2A:
19.40