SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hfe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 10 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.29A 1a52A-1hfeL:
undetectable		 1a52A-1hfeL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 10 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.30A 1a52B-1hfeL:
undetectable		 1a52B-1hfeL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 ARG L 243
GLY L 208
ALA L 209
GLY L 250
THR S  90
 None
 1.08A 1c6zA-1hfeL:
undetectable		 1c6zA-1hfeL:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 9 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.23A 1ereA-1hfeL:
undetectable		 1ereA-1hfeL:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 9 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.23A 1ereB-1hfeL:
undetectable		 1ereB-1hfeL:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 9 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.24A 1ereC-1hfeL:
undetectable		 1ereC-1hfeL:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 9 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.23A 1ereD-1hfeL:
undetectable		 1ereD-1hfeL:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 10 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.20A 1fohA-1hfeL:
undetectable		 1fohA-1hfeL:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 10 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.21A 1fohB-1hfeL:
0.0		 1fohB-1hfeL:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 10 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.18A 1fohC-1hfeL:
0.0		 1fohC-1hfeL:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 10 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.17A 1fohD-1hfeL:
0.0		 1fohD-1hfeL:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 5 SER L 198
THR L 199
GLU L 156
GLY L 157
 None
 1.26A 1icrA-1hfeL:
0.1
1icrB-1hfeL:
0.0		 1icrA-1hfeL:
20.24
1icrB-1hfeL:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 5 GLU L 156
GLY L 157
SER L 198
THR L 199
 None
 1.27A 1icrA-1hfeL:
0.1
1icrB-1hfeL:
0.0		 1icrA-1hfeL:
20.24
1icrB-1hfeL:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_A_NIOA704_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 4 SER L 198
PHE L 372
GLU L 159
GLY L 157
 None
 1.33A 1icvA-1hfeL:
0.0
1icvB-1hfeL:
0.0		 1icvA-1hfeL:
20.24
1icvB-1hfeL:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 5 SER L 198
THR L 199
GLU L 156
GLY L 157
 None
 1.25A 1icvC-1hfeL:
0.0
1icvD-1hfeL:
0.2		 1icvC-1hfeL:
20.24
1icvD-1hfeL:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 5 GLU L 156
GLY L 157
SER L 198
THR L 199
 None
 1.25A 1icvC-1hfeL:
0.1
1icvD-1hfeL:
0.2		 1icvC-1hfeL:
20.24
1icvD-1hfeL:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		3 / 3 ARG S 112
GLY L  37
ASP L  39
 None
SF4  L 422 (-3.5A)
None
 0.54A 1kf6A-1hfeS:
undetectable
1kf6B-1hfeS:
undetectable		 1kf6A-1hfeS:
11.64
1kf6B-1hfeS:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 5 GLU L 156
GLY L 157
SER L 198
THR L 199
 None
 1.27A 1kqbA-1hfeL:
0.0
1kqbB-1hfeL:
0.0		 1kqbA-1hfeL:
19.40
1kqbB-1hfeL:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 GLY L 300
MET L 376
THR L 152
ILE L 153
PHE L 296
 None
PDT  L 425 (-3.6A)
None
None
CMO  L 431 ( 4.5A)
 1.34A 1p93D-1hfeL:
undetectable		 1p93D-1hfeL:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 10 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.22A 1pn0A-1hfeL:
undetectable		 1pn0A-1hfeL:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 10 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.22A 1pn0B-1hfeL:
0.0		 1pn0B-1hfeL:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 10 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.20A 1pn0C-1hfeL:
0.0		 1pn0C-1hfeL:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 10 GLY L 297
VAL L 383
ILE S  47
TYR S  51
GLY L 301
 CYN  L 429 ( 3.7A)
None
None
None
None
 1.20A 1pn0D-1hfeL:
0.0		 1pn0D-1hfeL:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 8 ALA L 236
ILE L 235
CYH L 382
GLY L 385
 SF4  L 424 ( 4.0A)
None
SF4  L 424 (-2.3A)
SF4  L 424 ( 3.5A)
 0.85A 1sv9A-1hfeL:
undetectable		 1sv9A-1hfeL:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.23A 2j7xA-1hfeL:
0.0		 2j7xA-1hfeL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 12 GLY L 297
GLY L 381
VAL L 302
GLY L 301
TYR S  51
 CYN  L 429 ( 3.7A)
SF4  L 424 ( 4.4A)
None
None
None
 0.87A 2qe6A-1hfeL:
undetectable		 2qe6A-1hfeL:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.22A 2yjaB-1hfeL:
undetectable		 2yjaB-1hfeL:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 LEU L 134
MET L 105
ALA L 104
LEU L 242
LEU L 246
 None
 1.09A 3b0wB-1hfeL:
undetectable		 3b0wB-1hfeL:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		3 / 3 GLY L 292
ASP L 150
SER L 289
 None
 0.71A 3brfA-1hfeL:
0.0		 3brfA-1hfeL:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_1
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 VAL L 359
SER L 368
TRP L 182
PHE L 175
TYR L 185
 None
 1.46A 3d4sA-1hfeL:
undetectable		 3d4sA-1hfeL:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 5 PRO L 223
VAL L 226
GLY L 205
LYS L 201
 None
 1.19A 3elzB-1hfeL:
undetectable		 3elzB-1hfeL:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 7 GLN L 174
GLU L 240
GLU L 156
PRO L 203
 None
None
None
CYN  L 428 ( 3.6A)
 1.38A 3ql6A-1hfeL:
0.0		 3ql6A-1hfeL:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 8 GLY L 301
GLY L 300
GLY L 381
ILE S  47
VAL L 383
 None
None
SF4  L 424 ( 4.4A)
None
None
 1.31A 3v1nA-1hfeL:
undetectable		 3v1nA-1hfeL:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 VAL L 359
SER L 368
TRP L 182
PHE L 175
TYR L 185
 None
 1.43A 4amjA-1hfeL:
undetectable		 4amjA-1hfeL:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		4 / 7 ALA L 113
TYR L 112
GLY S  49
ILE S  47
 None
 0.64A 4eatA-1hfeL:
2.1		 4eatA-1hfeL:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 7 ASN L  68
GLY L  70
THR L  74
ILE L   9
 None
SF4  L 423 (-3.9A)
CYS  L 432 (-3.3A)
None
 0.88A 4ejjA-1hfeL:
undetectable		 4ejjA-1hfeL:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 8 ASP L 255
SER L 230
THR L 145
GLY L 205
 None
None
CMO  L 431 ( 4.9A)
None
 0.97A 4fo4A-1hfeL:
undetectable		 4fo4A-1hfeL:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.20A 4j26A-1hfeL:
undetectable		 4j26A-1hfeL:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.20A 4j26B-1hfeL:
undetectable		 4j26B-1hfeL:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 12 ARG L 243
GLY L 208
ALA L 209
GLY L 250
THR S  90
 None
 1.05A 4njvD-1hfeL:
undetectable		 4njvD-1hfeL:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 7 PRO L 180
GLU L 240
ASP S  54
THR L 290
 SF4  L 424 (-4.3A)
None
None
None
 1.12A 4uacA-1hfeL:
0.1		 4uacA-1hfeL:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 6 ALA L 348
VAL L 350
TYR L 375
VAL L 363
 None
 0.94A 5eckA-1hfeL:
undetectable		 5eckA-1hfeL:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 6 ALA L 348
VAL L 350
TYR L 375
VAL L 363
 None
 0.95A 5eckD-1hfeL:
undetectable		 5eckD-1hfeL:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 6 ALA L 348
VAL L 350
TYR L 375
VAL L 363
 None
 1.01A 5eclA-1hfeL:
0.0		 5eclA-1hfeL:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 6 VAL L 229
LEU L 258
CYH L 102
LEU L  95
 None
 1.22A 5hrqB-1hfeL:
undetectable
5hrqI-1hfeL:
undetectable
5hrqJ-1hfeL:
undetectable		 5hrqB-1hfeL:
6.08
5hrqI-1hfeL:
3.82
5hrqJ-1hfeL:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		4 / 4 GLY L 123
ALA L 113
MET L 391
THR L 260
 None
None
CYS  L 432 (-3.7A)
None
 1.34A 5n0sB-1hfeL:
0.8		 5n0sB-1hfeL:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		3 / 3 LYS L 237
LYS L 201
SER L 202
 CYN  L 428 (-2.8A)
None
CYN  L 428 ( 3.8A)
 1.19A 5odiA-1hfeL:
2.0		 5odiA-1hfeL:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		5 / 12 THR L 294
GLY L 292
PRO L 108
LEU S  88
ASN S  65
 None
None
CYN  L 429 ( 3.6A)
None
None
 1.09A 5ybbA-1hfeL:
undetectable		 5ybbA-1hfeL:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		3 / 3 ASP L 150
PHE S  57
ARG L 282
 None
 0.84A 5yw0A-1hfeL:
0.0		 5yw0A-1hfeL:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(SMALLER SUBUNIT))
(Desulfovibrio
vulgaris;
Desulfovibrio
vulgaris) 		4 / 6 VAL S  50
ILE L 295
GLU L 304
ARG L 328
 None
 1.05A 5z3jA-1hfeS:
undetectable		 5z3jA-1hfeS:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))
(Desulfovibrio
vulgaris) 		5 / 10 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.35A 6cbzB-1hfeL:
undetectable		 6cbzB-1hfeL:
12.75