SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hfh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1hfh FACTOR H, 15TH AND
16TH C-MODULE PAIR
(Homo
sapiens) 		4 / 7 TYR A  26
SER A  19
SER A  18
SER A  21
 None
 1.03A 2i91A-1hfhA:
undetectable		 2i91A-1hfhA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1hfh FACTOR H, 15TH AND
16TH C-MODULE PAIR
(Homo
sapiens) 		4 / 7 TYR A  26
SER A  19
SER A  18
SER A  21
 None
 1.03A 2i91B-1hfhA:
undetectable		 2i91B-1hfhA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1hfh FACTOR H, 15TH AND
16TH C-MODULE PAIR
(Homo
sapiens) 		5 / 12 THR A  30
ARG A  20
ILE A  16
ASN A  17
SER A  33
 None
 1.42A 4c49B-1hfhA:
undetectable		 4c49B-1hfhA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1hfh FACTOR H, 15TH AND
16TH C-MODULE PAIR
(Homo
sapiens) 		4 / 8 HIS A  13
TYR A  34
ILE A  42
GLU A  12
 None
 1.36A 4ms4A-1hfhA:
undetectable		 4ms4A-1hfhA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1hfh FACTOR H, 15TH AND
16TH C-MODULE PAIR
(Homo
sapiens) 		4 / 8 PRO A   9
LYS A  54
THR A  48
TYR A  34
 None
 1.04A 5x2sI-1hfhA:
undetectable
5x2sJ-1hfhA:
undetectable
5x2sK-1hfhA:
undetectable		 5x2sI-1hfhA:
19.87
5x2sJ-1hfhA:
18.83
5x2sK-1hfhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1hfh FACTOR H, 15TH AND
16TH C-MODULE PAIR
(Homo
sapiens) 		4 / 8 PRO A   9
THR A  49
THR A  48
TYR A  34
 None
 1.31A 5x2sI-1hfhA:
undetectable
5x2sJ-1hfhA:
undetectable
5x2sK-1hfhA:
undetectable		 5x2sI-1hfhA:
19.87
5x2sJ-1hfhA:
18.83
5x2sK-1hfhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 1hfh FACTOR H, 15TH AND
16TH C-MODULE PAIR
(Homo
sapiens) 		3 / 3 ARG A  41
GLY A  63
GLU A  62
 None
 0.61A 6fgdA-1hfhA:
undetectable		 6fgdA-1hfhA:
13.81