SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hg0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		4 / 8 ARG A 258
VAL A 257
SER A 256
ASP A 228
 None
 1.19A 1hwiB-1hg0A:
undetectable		 1hwiB-1hg0A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		3 / 3 ASP A 112
LYS A 110
ARG A 212
 None
 1.03A 1ra8A-1hg0A:
0.0		 1ra8A-1hg0A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		4 / 8 MET A 133
VAL A  52
LEU A  49
VAL A 155
 None
 1.03A 2bdmA-1hg0A:
0.0		 2bdmA-1hg0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		5 / 10 HIS A  93
ASN A  59
ALA A  31
ALA A  61
SER A  62
 None
None
SIN  A 350 ( 4.0A)
SIN  A 350 (-3.8A)
SIN  A 350 (-2.4A)
 1.33A 2r2vC-1hg0A:
0.0
2r2vF-1hg0A:
undetectable
2r2vG-1hg0A:
0.0		 2r2vC-1hg0A:
9.09
2r2vF-1hg0A:
9.09
2r2vG-1hg0A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		4 / 8 ASN A 134
ILE A 166
VAL A 187
TYR A 184
 None
 0.82A 2yoeB-1hg0A:
0.0
2yoeC-1hg0A:
0.0		 2yoeB-1hg0A:
23.38
2yoeC-1hg0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		3 / 3 GLY A 225
GLY A 251
GLY A 249
 None
 0.40A 3bogC-1hg0A:
undetectable		 3bogC-1hg0A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		4 / 4 THR A 312
VAL A 220
GLY A  67
THR A  66
 None
 1.09A 3cflA-1hg0A:
1.7		 3cflA-1hg0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		5 / 12 LEU A 174
ASN A  59
GLY A  32
GLY A 131
LEU A  39
 None
 1.11A 3ku1G-1hg0A:
undetectable		 3ku1G-1hg0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		5 / 11 SER A  74
VAL A 115
VAL A 152
HIS A  93
ILE A  91
 None
 1.22A 3rf4A-1hg0A:
0.5
3rf4C-1hg0A:
0.0		 3rf4A-1hg0A:
18.33
3rf4C-1hg0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		5 / 11 HIS A  93
ILE A  91
SER A  74
VAL A 115
VAL A 152
 None
 1.24A 3rf4A-1hg0A:
0.5
3rf4B-1hg0A:
0.5		 3rf4A-1hg0A:
18.33
3rf4B-1hg0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		4 / 7 GLY A 131
ILE A  16
VAL A 139
VAL A  46
 None
 0.75A 3ufnB-1hg0A:
undetectable		 3ufnB-1hg0A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		5 / 12 ILE A  16
LEU A  39
ILE A   9
ALA A  11
ILE A 156
 None
 1.00A 3vrmA-1hg0A:
0.0		 3vrmA-1hg0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		3 / 3 ASP A 130
ARG A 122
ASP A 175
 None
 0.83A 4fp9D-1hg0A:
undetectable		 4fp9D-1hg0A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		3 / 3 ASP A 130
ARG A 122
ASP A 175
 None
 0.79A 4fzvA-1hg0A:
undetectable		 4fzvA-1hg0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		5 / 12 THR A  12
GLY A  94
THR A  95
ALA A 119
ASP A 130
 None
SIN  A 350 (-3.3A)
SIN  A 350 (-2.8A)
None
None
 1.25A 4qvyV-1hg0A:
undetectable
4qvyW-1hg0A:
undetectable		 4qvyV-1hg0A:
22.89
4qvyW-1hg0A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		5 / 12 GLY A  13
VAL A  46
VAL A  52
GLY A  54
ILE A   9
 None
 0.76A 5vopA-1hg0A:
2.9		 5vopA-1hg0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		3 / 3 ASP A 130
ARG A 122
ASP A 175
 None
 0.80A 5zvgA-1hg0A:
undetectable		 5zvgA-1hg0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		3 / 3 ASP A 130
ARG A 122
ASP A 175
 None
 0.79A 5zvgB-1hg0A:
undetectable		 5zvgB-1hg0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1hg0 L-ASPARAGINASE
(Dickeya
chrysanthemi) 		5 / 12 ALA A  42
PHE A 177
VAL A 154
HIS A  93
LEU A  34
 None
 1.05A 6djzC-1hg0A:
0.0		 6djzC-1hg0A:
22.52