SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		4 / 5 LEU A 221
PRO A 214
ALA A 217
ILE A 218
 None
 1.01A 2aofB-1hg3A:
undetectable		 2aofB-1hg3A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		4 / 8 VAL A 170
VAL A 179
LEU A 169
PRO A 127
 None
 0.92A 2ddwA-1hg3A:
undetectable		 2ddwA-1hg3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 12 VAL A 202
ILE A   9
ILE A  42
ILE A 218
ALA A  30
 None
 1.17A 2gj5A-1hg3A:
0.3		 2gj5A-1hg3A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 9 GLY A 152
LEU A 204
SER A 186
LEU A 221
ASP A 190
 None
 1.31A 2j2pB-1hg3A:
undetectable
2j2pC-1hg3A:
undetectable		 2j2pB-1hg3A:
20.08
2j2pC-1hg3A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 12 LEU A 180
ALA A 194
ILE A 185
GLY A 224
ILE A 225
 None
 1.00A 2o4nA-1hg3A:
undetectable		 2o4nA-1hg3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		4 / 8 ALA A 183
LYS A  14
SER A 206
ALA A 205
 3PP  A1226 (-4.4A)
3PP  A1226 (-3.3A)
3PP  A1226 (-2.8A)
3PP  A1226 (-3.1A)
 0.76A 2vh3B-1hg3A:
undetectable		 2vh3B-1hg3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		4 / 8 ARG A  23
ALA A  24
ILE A  27
PRO A 214
 None
 0.91A 3fxrA-1hg3A:
0.0		 3fxrA-1hg3A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 11 VAL A 162
PRO A 127
PRO A 145
ILE A 185
ILE A 153
 None
 1.42A 3ganA-1hg3A:
undetectable		 3ganA-1hg3A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		3 / 3 CYH A 181
PRO A 160
ASP A 190
 None
 0.95A 3hlwB-1hg3A:
undetectable		 3hlwB-1hg3A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 12 SER A  57
VAL A  62
VAL A  44
PRO A  46
PHE A  13
 None
 1.05A 3nbrA-1hg3A:
undetectable		 3nbrA-1hg3A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 11 VAL A  90
ALA A  89
GLY A  88
ALA A  28
LEU A   4
 None
 1.23A 3rc0A-1hg3A:
undetectable		 3rc0A-1hg3A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 12 THR A 120
THR A  92
ILE A  67
LEU A 106
VAL A 133
 None
 1.23A 3sp9A-1hg3A:
0.0		 3sp9A-1hg3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 12 THR A 120
THR A  92
ILE A  67
LEU A 106
VAL A 133
 None
 1.21A 3sp9B-1hg3A:
0.0		 3sp9B-1hg3A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 12 LEU A 180
LEU A 203
GLY A 182
VAL A 122
THR A 166
 None
3PP  A1226 ( 4.4A)
None
None
None
 1.37A 4olmA-1hg3A:
undetectable		 4olmA-1hg3A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		3 / 3 LEU A  94
LEU A 180
ASN A  12
 None
None
3PP  A1226 (-3.9A)
 0.71A 4otwA-1hg3A:
undetectable		 4otwA-1hg3A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		3 / 3 CYH A 181
PRO A 160
ASP A 190
 None
 0.99A 4pm5A-1hg3A:
undetectable		 4pm5A-1hg3A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		4 / 5 ILE A 225
VAL A  40
ILE A  42
VAL A 222
 None
 0.64A 4xdtA-1hg3A:
0.0		 4xdtA-1hg3A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 10 ALA A  83
GLU A  82
LEU A  80
ARG A 112
GLY A  77
 None
 1.36A 5dx3A-1hg3A:
undetectable		 5dx3A-1hg3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 10 ALA A  83
GLU A  82
LEU A  80
ARG A 112
GLY A  77
 None
 1.39A 5dxbA-1hg3A:
0.0		 5dxbA-1hg3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_A_PZAA1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		4 / 7 VAL A  58
SER A  57
GLY A  88
VAL A  62
 None
 0.94A 5fpdA-1hg3A:
undetectable		 5fpdA-1hg3A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1hg3 TRIOSEPHOSPHATE
ISOMERASE
(Pyrococcus
woesei) 		5 / 9 ALA A  83
GLU A  82
LEU A  80
ARG A 112
GLY A  77
 None
 1.43A 5wgqA-1hg3A:
0.0		 5wgqA-1hg3A:
16.96