SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 10 VAL A  46
LEU A  47
LEU A 144
GLY A  99
ALA A 100
 None
 1.11A 1pxxA-1hg8A:
0.0		 1pxxA-1hg8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 9 VAL A  46
LEU A  47
LEU A 144
GLY A  99
ALA A 100
 None
 1.12A 1pxxB-1hg8A:
0.0		 1pxxB-1hg8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 10 VAL A  46
LEU A  47
LEU A 144
GLY A  99
ALA A 100
 None
 1.12A 1pxxD-1hg8A:
undetectable		 1pxxD-1hg8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 12 ILE A  88
ILE A 105
PHE A  71
ILE A 146
LEU A 167
 None
 0.92A 1qhsA-1hg8A:
undetectable		 1qhsA-1hg8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 12 ILE A  88
ILE A 105
PHE A  71
ILE A 146
LEU A 167
 None
 0.93A 1qhyA-1hg8A:
undetectable		 1qhyA-1hg8A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		3 / 3 SER A 257
VAL A 215
LEU A 236
 None
 0.65A 1yajG-1hg8A:
0.0		 1yajG-1hg8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		3 / 3 ASP A 191
ILE A 238
VAL A 201
 None
 0.68A 2avvD-1hg8A:
undetectable		 2avvD-1hg8A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		3 / 3 ASP A 170
ASP A 106
ASN A 210
 None
 0.61A 2bm9D-1hg8A:
undetectable		 2bm9D-1hg8A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 12 SER A 139
LEU A  47
ASP A  59
VAL A  39
ALA A  36
 None
 1.35A 2kceA-1hg8A:
0.0		 2kceA-1hg8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 12 GLY A 239
ASN A 247
GLY A 220
ILE A 223
ILE A 278
 None
 1.00A 2pymA-1hg8A:
undetectable		 2pymA-1hg8A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 12 GLY A 239
ASN A 247
GLY A 220
ILE A 223
ILE A 278
 None
 1.00A 2pynB-1hg8A:
undetectable		 2pynB-1hg8A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 11 ILE A 238
ALA A 216
ASP A 213
SER A 257
ILE A 286
 None
 1.35A 3qg2B-1hg8A:
undetectable		 3qg2B-1hg8A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		4 / 8 VAL A 315
VAL A 281
ILE A 268
GLN A 300
 None
 1.01A 3remA-1hg8A:
undetectable		 3remA-1hg8A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		4 / 8 VAL A 315
VAL A 281
ILE A 268
GLN A 300
 None
 1.01A 3remB-1hg8A:
undetectable		 3remB-1hg8A:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 12 LEU A  58
ILE A  88
GLY A 107
PHE A  77
ILE A 146
 None
 0.98A 3uwlB-1hg8A:
0.0		 3uwlB-1hg8A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 12 SER A 159
VAL A 132
ILE A 141
SER A 165
PHE A 154
 None
 1.49A 4c49B-1hg8A:
0.0		 4c49B-1hg8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 12 SER A 159
VAL A 132
ILE A 141
SER A 165
PHE A 154
 None
 1.48A 4c49C-1hg8A:
undetectable		 4c49C-1hg8A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		4 / 8 ILE A 317
PRO A 372
VAL A 296
TRP A 336
 None
 1.02A 4f4dB-1hg8A:
undetectable		 4f4dB-1hg8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 12 GLN A  64
ASN A  65
SER A  67
VAL A  69
ILE A  45
 None
NAG  A1374 (-2.5A)
None
None
None
 1.32A 4k39A-1hg8A:
undetectable		 4k39A-1hg8A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		4 / 5 TYR A 294
GLN A 334
SER A 363
ASP A 301
 None
 1.19A 4qtuB-1hg8A:
undetectable		 4qtuB-1hg8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		4 / 5 LEU A 236
SER A 237
ASP A 194
ASP A 127
 None
 1.33A 4qtuD-1hg8A:
undetectable		 4qtuD-1hg8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		6 / 12 TYR A 112
GLY A 109
GLN A 110
LEU A  58
PHE A  71
ILE A  95
 None
 1.41A 5fsaB-1hg8A:
0.0		 5fsaB-1hg8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		4 / 4 THR A  98
LEU A 144
HIS A 103
GLY A 166
 None
 1.31A 5gwyA-1hg8A:
0.0		 5gwyA-1hg8A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		3 / 3 ILE A 238
MET A 228
ASP A 213
 None
 0.81A 5h2uA-1hg8A:
undetectable		 5h2uA-1hg8A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		4 / 7 PHE A 129
ILE A 146
GLY A 192
PHE A 154
 None
 0.87A 5h3aA-1hg8A:
0.0		 5h3aA-1hg8A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		4 / 5 SER A 219
SER A 197
SER A 196
SER A 245
 None
 1.41A 5hswA-1hg8A:
0.0		 5hswA-1hg8A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		4 / 6 SER A 362
GLY A 295
ILE A 338
TRP A 336
 None
 1.15A 5j4nA-1hg8A:
undetectable		 5j4nA-1hg8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 1hg8 ENDOPOLYGALACTURONAS
E
(Fusarium
verticillioides) 		5 / 12 LEU A  58
ILE A  88
GLY A 107
PHE A  77
ILE A 146
 None
 1.01A 6qxsB-1hg8A:
0.0		 6qxsB-1hg8A:
20.53