SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1hgx HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Tritrichomonas
suis) 		4 / 8 VAL A 143
VAL A  98
VAL A 100
LEU A 115
 None
 0.84A 1igxA-1hgxA:
undetectable		 1igxA-1hgxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1hgx HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Tritrichomonas
suis) 		4 / 4 ASP A 163
GLY A  48
ASP A 103
ASP A 106
 None
None
5GP  A 600 (-2.8A)
5GP  A 600 (-4.2A)
 1.14A 5e72A-1hgxA:
2.2		 5e72A-1hgxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1hgx HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE
(Tritrichomonas
suis) 		5 / 12 ILE A 174
LEU A 131
PHE A 162
ARG A 169
GLY A 159
 None
None
5GP  A 600 ( 4.9A)
None
None
 1.35A 5k7uA-1hgxA:
undetectable		 5k7uA-1hgxA:
21.03