SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hh2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		5 / 12 TRP P 166
VAL P 142
ALA P 150
ILE P 152
ILE P 154
 None
 0.94A 1epbA-1hh2P:
undetectable		 1epbA-1hh2P:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		4 / 7 GLY P 248
ASP P 241
ILE P 219
VAL P 220
 None
 0.74A 1p2yA-1hh2P:
0.0		 1p2yA-1hh2P:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		4 / 8 ILE P 336
ASP P 337
ILE P 338
GLY P 319
 None
 0.79A 4ac9C-1hh2P:
undetectable		 4ac9C-1hh2P:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		4 / 8 ILE P 336
ASP P 337
ILE P 338
GLY P 319
 None
 0.80A 4acaC-1hh2P:
undetectable		 4acaC-1hh2P:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		3 / 3 ARG P 160
ARG P 144
TRP P 149
 None
 1.46A 4cpzC-1hh2P:
undetectable		 4cpzC-1hh2P:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		5 / 10 ASP P 176
ILE P 152
VAL P 180
VAL P 145
VAL P 142
 None
 1.02A 4j5jB-1hh2P:
undetectable		 4j5jB-1hh2P:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		4 / 7 LEU P   6
GLU P   7
ILE P  56
VAL P  47
 None
 1.22A 4tvtA-1hh2P:
undetectable		 4tvtA-1hh2P:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_C_CLQC1079_0
(SAPOSIN-B)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		4 / 5 ARG P 227
MET P 208
GLU P 264
LEU P 265
 None
 1.24A 4v2oA-1hh2P:
1.2
4v2oC-1hh2P:
1.2		 4v2oA-1hh2P:
13.27
4v2oC-1hh2P:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		4 / 7 GLU P 228
GLY P 322
ARG P 232
ALA P 325
 None
 0.88A 5e26A-1hh2P:
undetectable
5e26B-1hh2P:
undetectable		 5e26A-1hh2P:
22.14
5e26B-1hh2P:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		4 / 7 GLU P 228
GLY P 322
ARG P 232
ALA P 325
 None
 0.89A 5e26C-1hh2P:
undetectable
5e26D-1hh2P:
undetectable		 5e26C-1hh2P:
22.14
5e26D-1hh2P:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		3 / 3 VAL P  23
GLU P  22
ILE P  18
 None
 0.64A 6f7lB-1hh2P:
undetectable		 6f7lB-1hh2P:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1hh2 N UTILIZATION
SUBSTANCE PROTEIN A
(Thermotoga
maritima) 		4 / 7 VAL P 204
ILE P 212
ARG P 232
ALA P 259
 None
 0.87A 6hd6B-1hh2P:
undetectable		 6hd6B-1hh2P:
13.49