SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hh4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1
(Homo
sapiens) 		5 / 12 TYR D 428
ILE D 412
GLY D 374
ILE D 414
LEU D 394
 None
GER  D1502 ( 4.3A)
None
None
None
 1.02A 3uj6A-1hh4D:
undetectable		 3uj6A-1hh4D:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1
(Homo
sapiens) 		4 / 6 ASP D 440
ILE D 429
TYR D 428
TYR D 410
 None
None
None
GER  D1502 (-4.9A)
 1.29A 5igyA-1hh4D:
undetectable		 5igyA-1hh4D:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1hh4 RHO GDP-DISSOCIATION
INHIBITOR 1
(Homo
sapiens) 		4 / 6 ASP D 440
ILE D 429
TYR D 428
TYR D 410
 None
None
None
GER  D1502 (-4.9A)
 1.25A 5ih0A-1hh4D:
0.0		 5ih0A-1hh4D:
21.55