SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		3 / 3 VAL A 116
VAL A 139
TRP A 158
 None
 0.95A 1av2A-1hixA:
undetectable
1av2B-1hixA:
undetectable		 1av2A-1hixA:
8.86
1av2B-1hixA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		5 / 12 VAL A  27
TYR A 171
GLY A  50
ALA A  49
SER A  18
 None
 1.02A 1eqhA-1hixA:
0.0		 1eqhA-1hixA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		5 / 12 VAL A  27
TYR A 171
GLY A  50
ALA A  49
SER A  18
 None
 1.01A 1eqhB-1hixA:
undetectable		 1eqhB-1hixA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		3 / 3 GLU A 128
GLU A  87
LEU A 165
 None
 0.72A 1v8bA-1hixA:
undetectable		 1v8bA-1hixA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		3 / 3 GLU A 128
GLU A  87
LEU A 165
 None
 0.73A 1v8bB-1hixA:
undetectable		 1v8bB-1hixA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		3 / 3 VAL A 116
VAL A 139
TRP A 158
 None
 0.86A 1w5uA-1hixA:
undetectable
1w5uB-1hixA:
undetectable		 1w5uA-1hixA:
8.86
1w5uB-1hixA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		3 / 3 VAL A 139
TRP A 158
VAL A 116
 None
 0.90A 2izqC-1hixA:
undetectable
2izqD-1hixA:
undetectable		 2izqC-1hixA:
8.86
2izqD-1hixA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		5 / 12 VAL A  27
TYR A 171
GLY A  50
ALA A  49
SER A  18
 None
 1.11A 3rr3C-1hixA:
0.0		 3rr3C-1hixA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		5 / 12 VAL A  27
TYR A 171
GLY A  50
ALA A  49
SER A  18
 None
 1.12A 3rr3D-1hixA:
0.0		 3rr3D-1hixA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		5 / 12 GLY A  10
ILE A 187
GLY A  52
ALA A  49
SER A 185
 None
 1.04A 3sudB-1hixA:
undetectable		 3sudB-1hixA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		5 / 8 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
 None
 0.48A 5tzoA-1hixA:
27.6		 5tzoA-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		6 / 12 VAL A  48
TRP A  80
TYR A  89
PRO A 125
TRP A 137
TYR A 171
 None
 0.56A 5tzoA-1hixA:
27.6		 5tzoA-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		6 / 12 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.63A 5tzoA-1hixA:
27.6		 5tzoA-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		6 / 12 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.54A 5tzoB-1hixA:
27.7		 5tzoB-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		3 / 3 ARG A 121
PRO A 125
TYR A 179
 None
 0.80A 5tzoB-1hixA:
27.7		 5tzoB-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		5 / 8 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
 None
 0.46A 5tzoB-1hixA:
27.7		 5tzoB-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		6 / 12 VAL A  48
TRP A  80
TYR A  89
PRO A 125
TRP A 137
TYR A 171
 None
 0.58A 5tzoC-1hixA:
27.6		 5tzoC-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		6 / 12 VAL A  48
TRP A  80
TYR A  89
TRP A 137
TYR A 171
GLY A 178
 None
 0.70A 5tzoC-1hixA:
27.6		 5tzoC-1hixA:
54.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		5 / 8 TYR A 117
THR A 119
ARG A 121
GLN A 135
TRP A 137
 None
 0.43A 5tzoC-1hixA:
27.6		 5tzoC-1hixA:
54.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		4 / 5 GLY A  95
THR A  96
SER A 182
SER A 181
 None
 0.76A 6jmjA-1hixA:
undetectable		 6jmjA-1hixA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		4 / 7 GLY A  95
THR A  96
SER A 182
SER A 181
 None
 0.73A 6jnhA-1hixA:
undetectable		 6jnhA-1hixA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1hix ENDO-1,4-BETA-XYLANA
SE
(Streptomyces
sp.
S38) 		4 / 6 GLY A  95
THR A  96
SER A 182
SER A 181
 None
 0.73A 6jogA-1hixA:
undetectable		 6jogA-1hixA:
20.10