SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hjo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		5 / 12 GLY A  19
ALA A 370
SER A  16
ALA A 131
ILE A   7
 None
 1.15A 1nt2A-1hjoA:
0.6		 1nt2A-1hjoA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		5 / 12 GLY A 230
GLY A 202
GLY A 203
LEU A 228
ASN A 235
 ADP  A 383 (-3.2A)
ADP  A 383 (-3.2A)
None
None
None
 0.88A 1qzzA-1hjoA:
undetectable		 1qzzA-1hjoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		5 / 12 TYR A  41
GLY A 230
GLY A 202
LEU A 228
ASN A 235
 None
ADP  A 383 (-3.2A)
ADP  A 383 (-3.2A)
None
None
 0.93A 1qzzA-1hjoA:
undetectable		 1qzzA-1hjoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		3 / 3 LYS A 246
ILE A 291
THR A 295
 None
 0.77A 1rx3A-1hjoA:
undetectable		 1rx3A-1hjoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		5 / 12 GLY A 230
GLY A 202
GLY A 203
LEU A 228
ASN A 235
 ADP  A 383 (-3.2A)
ADP  A 383 (-3.2A)
None
None
None
 0.95A 1xdsA-1hjoA:
undetectable		 1xdsA-1hjoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		5 / 12 GLY A 230
GLY A 202
GLY A 203
LEU A 228
ASN A 235
 ADP  A 383 (-3.2A)
ADP  A 383 (-3.2A)
None
None
None
 0.93A 1xdsB-1hjoA:
undetectable		 1xdsB-1hjoA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		5 / 12 GLY A 372
ALA A 368
ALA A 182
TYR A 183
ARG A 187
 None
 1.29A 2avdB-1hjoA:
0.1		 2avdB-1hjoA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		3 / 3 SER A 153
GLU A 117
ASP A  97
 None
 0.91A 2avdB-1hjoA:
undetectable		 2avdB-1hjoA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		6 / 12 ALA A 157
ILE A 144
GLY A 162
ILE A 164
ALA A  70
ILE A  74
 None
 1.20A 2nmzB-1hjoA:
undetectable		 2nmzB-1hjoA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		4 / 7 ILE A   7
THR A 158
ILE A  29
GLY A  12
 None
None
None
ADP  A 383 (-3.5A)
 0.86A 2v0mB-1hjoA:
undetectable		 2v0mB-1hjoA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		4 / 5 VAL A 238
THR A 295
THR A 265
ARG A 264
 None
 1.12A 3bjwA-1hjoA:
0.0		 3bjwA-1hjoA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		4 / 5 VAL A 238
THR A 295
THR A 265
ARG A 264
 None
 1.18A 3bjwC-1hjoA:
0.0		 3bjwC-1hjoA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		4 / 4 PHE A 245
LYS A 246
ILE A 291
THR A 295
 None
 0.72A 3ia4B-1hjoA:
undetectable		 3ia4B-1hjoA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		5 / 10 ILE A 212
ALA A 178
ILE A 197
VAL A 335
VAL A 195
 None
 0.94A 3me6A-1hjoA:
undetectable		 3me6A-1hjoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		4 / 5 PHE A 245
ILE A 253
GLY A 290
HIS A 249
 None
 1.22A 3r0lD-1hjoA:
undetectable		 3r0lD-1hjoA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		3 / 3 LYS A 246
ILE A 291
THR A 295
 None
 0.81A 4gh8A-1hjoA:
undetectable		 4gh8A-1hjoA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		5 / 12 ASP A  53
VAL A  42
MET A 127
ALA A  30
LEU A  11
 None
 1.14A 4nc3A-1hjoA:
undetectable		 4nc3A-1hjoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		4 / 7 GLU A 175
THR A  13
GLY A  12
THR A  14
 None
None
ADP  A 383 (-3.5A)
ADP  A 383 (-2.9A)
 0.96A 4qwpB-1hjoA:
undetectable		 4qwpB-1hjoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		4 / 4 ILE A 363
ILE A 181
ARG A 187
TYR A 371
 None
 1.36A 4zzbC-1hjoA:
0.0		 4zzbC-1hjoA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		8 / 10 GLY A 201
GLY A 230
LYS A 271
ARG A 272
SER A 275
GLY A 339
SER A 340
ILE A 343
 ADP  A 383 (-3.6A)
ADP  A 383 (-3.2A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.5A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.2A)
ADP  A 383 (-3.5A)
ADP  A 383 ( 4.9A)
 0.96A 5aqfA-1hjoA:
55.5		 5aqfA-1hjoA:
88.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		9 / 10 GLY A 202
GLY A 230
GLU A 268
LYS A 271
ARG A 272
SER A 275
GLY A 339
SER A 340
ILE A 343
 ADP  A 383 (-3.2A)
ADP  A 383 (-3.2A)
ADP  A 383 (-3.5A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.5A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.2A)
ADP  A 383 (-3.5A)
ADP  A 383 ( 4.9A)
 0.19A 5aqfA-1hjoA:
55.5		 5aqfA-1hjoA:
88.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_A_ADNA1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		6 / 10 GLY A 229
GLY A 230
LYS A 271
SER A 275
SER A 340
ILE A 343
 None
ADP  A 383 (-3.2A)
ADP  A 383 (-2.6A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.5A)
ADP  A 383 ( 4.9A)
 1.39A 5aqfA-1hjoA:
55.5		 5aqfA-1hjoA:
88.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		8 / 10 GLY A 201
GLY A 230
LYS A 271
ARG A 272
SER A 275
GLY A 339
SER A 340
ILE A 343
 ADP  A 383 (-3.6A)
ADP  A 383 (-3.2A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.5A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.2A)
ADP  A 383 (-3.5A)
ADP  A 383 ( 4.9A)
 0.96A 5aqfC-1hjoA:
55.2		 5aqfC-1hjoA:
88.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		9 / 10 GLY A 202
GLY A 230
GLU A 268
LYS A 271
ARG A 272
SER A 275
GLY A 339
SER A 340
ILE A 343
 ADP  A 383 (-3.2A)
ADP  A 383 (-3.2A)
ADP  A 383 (-3.5A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.5A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.2A)
ADP  A 383 (-3.5A)
ADP  A 383 ( 4.9A)
 0.21A 5aqfC-1hjoA:
55.2		 5aqfC-1hjoA:
88.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQF_C_ADNC1382_1
(HEAT SHOCK COGNATE
71 KDA PROTEIN)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		6 / 10 GLY A 229
GLY A 230
LYS A 271
SER A 275
SER A 340
ILE A 343
 None
ADP  A 383 (-3.2A)
ADP  A 383 (-2.6A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.5A)
ADP  A 383 ( 4.9A)
 1.38A 5aqfC-1hjoA:
55.2		 5aqfC-1hjoA:
88.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		8 / 10 GLY A 201
GLY A 230
LYS A 271
ARG A 272
SER A 275
GLY A 339
SER A 340
ILE A 343
 ADP  A 383 (-3.6A)
ADP  A 383 (-3.2A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.5A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.2A)
ADP  A 383 (-3.5A)
ADP  A 383 ( 4.9A)
 0.93A 5aqyA-1hjoA:
59.2		 5aqyA-1hjoA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		9 / 10 GLY A 202
GLY A 230
GLU A 268
LYS A 271
ARG A 272
SER A 275
GLY A 339
SER A 340
ILE A 343
 ADP  A 383 (-3.2A)
ADP  A 383 (-3.2A)
ADP  A 383 (-3.5A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.5A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.2A)
ADP  A 383 (-3.5A)
ADP  A 383 ( 4.9A)
 0.22A 5aqyA-1hjoA:
59.2		 5aqyA-1hjoA:
99.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AQY_A_ADNA1389_1
(HEAT SHOCK 70 KDA
PROTEIN 1A)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		6 / 10 GLY A 229
GLY A 230
LYS A 271
SER A 275
SER A 340
ILE A 343
 None
ADP  A 383 (-3.2A)
ADP  A 383 (-2.6A)
ADP  A 383 (-2.6A)
ADP  A 383 (-3.5A)
ADP  A 383 ( 4.9A)
 1.41A 5aqyA-1hjoA:
59.2		 5aqyA-1hjoA:
99.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		5 / 12 PHE A 233
GLY A 201
GLY A 339
ILE A 343
LEU A 237
 None
ADP  A 383 (-3.6A)
ADP  A 383 (-3.2A)
ADP  A 383 ( 4.9A)
None
 1.03A 5ul4A-1hjoA:
undetectable		 5ul4A-1hjoA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)
(Homo
sapiens) 		4 / 4 LYS A 220
LEU A 326
ALA A 221
LEU A 321
 None
 1.49A 6gnrB-1hjoA:
undetectable		 6gnrB-1hjoA:
17.37