SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hjq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		5 / 12 ILE A 125
ALA A  69
ASN A  58
LEU A  59
ARG A 119
 None
 1.19A 1dlsA-1hjqA:
undetectable		 1dlsA-1hjqA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		5 / 12 ILE A 125
ALA A  69
ASN A  58
LEU A  59
ARG A 119
 None
 1.19A 1u70A-1hjqA:
undetectable		 1u70A-1hjqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		3 / 3 ASN A 181
TYR A 257
SER A 220
 None
 0.94A 2gvcE-1hjqA:
0.0		 2gvcE-1hjqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		5 / 12 ILE A 125
ALA A  69
ASN A  58
LEU A  59
ARG A 119
 None
 1.18A 2w3mB-1hjqA:
undetectable		 2w3mB-1hjqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		4 / 8 GLY A 133
HIS A 178
ILE A 153
ALA A  87
 None
 0.88A 2x0pA-1hjqA:
0.0		 2x0pA-1hjqA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		5 / 12 ILE A 125
ALA A  69
ASN A  58
LEU A  59
ARG A 119
 None
 1.20A 3eigA-1hjqA:
undetectable		 3eigA-1hjqA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		4 / 7 TRP A 296
HIS A  81
TRP A  49
TRP A 300
 None
 1.04A 3s3gA-1hjqA:
3.3		 3s3gA-1hjqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		4 / 8 TRP A 296
HIS A  81
TRP A  49
TRP A 300
 None
 0.98A 3v35A-1hjqA:
7.4		 3v35A-1hjqA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		5 / 11 ALA A 161
LEU A 157
PHE A 201
VAL A 244
ILE A 129
 None
 1.12A 4claA-1hjqA:
0.0		 4claA-1hjqA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		3 / 3 VAL A  25
GLY A  27
LYS A  23
 None
 0.67A 4k50A-1hjqA:
0.0		 4k50A-1hjqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		3 / 3 VAL A  25
GLY A  27
LYS A  23
 None
 0.70A 4k50E-1hjqA:
undetectable		 4k50E-1hjqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		3 / 3 ASP A 186
ASN A 232
SER A 220
 None
 0.85A 4obwA-1hjqA:
undetectable		 4obwA-1hjqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		3 / 3 ASP A 224
ASN A 231
SER A 279
 None
 0.71A 4obwA-1hjqA:
undetectable		 4obwA-1hjqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		5 / 12 GLY A 133
VAL A 211
ARG A  45
ILE A 153
VAL A 195
 None
 1.35A 4okwA-1hjqA:
0.0		 4okwA-1hjqA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		5 / 12 LEU A 179
GLN A 188
LEU A 230
MET A 233
VAL A 291
 None
 1.47A 4okxA-1hjqA:
undetectable		 4okxA-1hjqA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		4 / 7 ILE A 136
LEU A 157
GLY A 145
LYS A 146
 None
 0.97A 4z69A-1hjqA:
0.0		 4z69A-1hjqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		3 / 3 VAL A 164
LEU A 196
MET A 203
 None
 0.87A 5ikrA-1hjqA:
0.0		 5ikrA-1hjqA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		5 / 11 GLU A  33
ASP A 128
ALA A  66
ILE A 125
VAL A 127
 None
 1.09A 5yk2A-1hjqA:
0.0		 5yk2A-1hjqA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		5 / 12 LEU A  74
GLY A  75
GLN A  46
VAL A  48
ILE A  78
 None
 1.33A 6bxnB-1hjqA:
undetectable		 6bxnB-1hjqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1hjq BETA-1,4-GALACTANASE
(Humicola
insolens) 		4 / 7 THR A 246
HIS A  91
GLU A 135
ASP A 180
 None
 1.20A 6mn4E-1hjqA:
0.0		 6mn4E-1hjqA:
23.41