SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hjr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)
(Escherichia
coli) 		5 / 12 VAL A 111
ALA A 103
GLU A  66
ILE A 145
ASP A 141
 None
 1.14A 1kxhA-1hjrA:
undetectable		 1kxhA-1hjrA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)
(Escherichia
coli) 		4 / 6 LEU A 143
VAL A  86
ILE A  65
ARG A  43
 None
 1.10A 1opjB-1hjrA:
undetectable		 1opjB-1hjrA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)
(Escherichia
coli) 		5 / 8 GLY A  31
ALA A 139
ASP A 141
GLY A   5
LEU A   4
 None
 1.32A 3em6A-1hjrA:
undetectable		 3em6A-1hjrA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)
(Escherichia
coli) 		5 / 12 ASP A 138
GLY A  29
SER A  30
ALA A 142
ASP A   7
 None
 1.10A 3keeA-1hjrA:
undetectable		 3keeA-1hjrA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)
(Escherichia
coli) 		5 / 12 ALA A  87
LEU A   4
ILE A  33
GLY A  16
ILE A  65
 None
 1.37A 3lbdA-1hjrA:
0.0		 3lbdA-1hjrA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)
(Escherichia
coli) 		4 / 5 VAL A 125
LEU A 128
ILE A  18
ALA A 146
 None
 1.00A 3n8yB-1hjrA:
undetectable		 3n8yB-1hjrA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)
(Escherichia
coli) 		4 / 6 ALA A 144
LYS A 107
THR A 148
THR A 109
 None
 1.49A 4w5rA-1hjrA:
3.8		 4w5rA-1hjrA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)
(Escherichia
coli) 		4 / 6 ALA A 144
LYS A 107
THR A 148
THR A 109
 None
 1.49A 4w5tA-1hjrA:
undetectable		 4w5tA-1hjrA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)
(Escherichia
coli) 		5 / 12 VAL A 106
ASP A   7
ILE A 145
GLY A   5
VAL A  98
 None
 1.12A 4y8wB-1hjrA:
0.0		 4y8wB-1hjrA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)
(Escherichia
coli) 		5 / 8 VAL A 106
ILE A 145
ALA A 142
VAL A 125
VAL A 121
 None
 1.14A 5l94A-1hjrA:
undetectable		 5l94A-1hjrA:
16.07