SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hju'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 9 HIS A  81
TRP A 296
ILE A  65
ASP A  54
GLY A  55
 None
TRS  A 704 (-3.8A)
None
None
None
 1.46A 1dwcH-1hjuA:
undetectable		 1dwcH-1hjuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 163
PRO A 173
VAL A 130
ALA A 116
PHE A  80
 None
 1.12A 1gseA-1hjuA:
0.0		 1gseA-1hjuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 6 LEU A 120
ALA A 116
LEU A 169
SER A 167
THR A 113
 None
 1.23A 1ictB-1hjuA:
undetectable		 1ictB-1hjuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 7 PRO A  52
ALA A  53
SER A  83
ALA A  96
 None
 1.06A 1k5qA-1hjuA:
0.0
1k5qB-1hjuA:
0.0		 1k5qA-1hjuA:
20.18
1k5qB-1hjuA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		3 / 3 ALA A 151
VAL A 195
TRP A 191
 None
 0.83A 1kqeA-1hjuA:
undetectable
1kqeE-1hjuA:
undetectable		 1kqeA-1hjuA:
5.38
1kqeE-1hjuA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		3 / 3 ALA A 151
VAL A 195
TRP A 191
 None
 0.85A 1kqeB-1hjuA:
undetectable
1kqeD-1hjuA:
undetectable		 1kqeB-1hjuA:
5.38
1kqeD-1hjuA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		3 / 3 TRP A 191
ALA A 151
VAL A 195
 None
 0.84A 1kqeB-1hjuA:
undetectable
1kqeD-1hjuA:
undetectable		 1kqeB-1hjuA:
5.38
1kqeD-1hjuA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		3 / 3 TRP A 191
ALA A 151
VAL A 195
 None
 0.86A 1kqeA-1hjuA:
undetectable
1kqeE-1hjuA:
undetectable		 1kqeA-1hjuA:
5.38
1kqeE-1hjuA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		3 / 3 ALA A 151
VAL A 195
TRP A 191
 None
 0.75A 1micA-1hjuA:
undetectable
1micB-1hjuA:
undetectable		 1micA-1hjuA:
3.45
1micB-1hjuA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 6 LEU A 326
ALA A 299
SER A 317
SER A 319
 None
 0.98A 1tz8C-1hjuA:
undetectable
1tz8D-1hjuA:
0.0		 1tz8C-1hjuA:
21.40
1tz8D-1hjuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 7 TYR A  82
GLY A 163
THR A 113
ASP A 166
 None
 1.01A 2g70A-1hjuA:
undetectable		 2g70A-1hjuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 7 TYR A  82
GLY A 163
THR A 113
ASP A 166
 None
 1.06A 2g70B-1hjuA:
undetectable		 2g70B-1hjuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 7 PRO A 127
LEU A 120
ALA A 116
PHE A  80
 None
 1.06A 2vcvL-1hjuA:
0.0		 2vcvL-1hjuA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 8 GLY A 133
HIS A 178
ILE A 153
ALA A  87
 None
 0.92A 2x0pA-1hjuA:
0.6		 2x0pA-1hjuA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 10 THR A 113
ILE A 164
GLY A 163
PRO A 173
ILE A 132
 None
 1.47A 2y7kB-1hjuA:
0.0		 2y7kB-1hjuA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 7 LEU A 120
ALA A 116
LEU A 169
SER A 167
THR A 113
 None
 1.21A 3cfqA-1hjuA:
undetectable
3cfqB-1hjuA:
undetectable		 3cfqA-1hjuA:
19.93
3cfqB-1hjuA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 7 LEU A 326
ALA A 299
SER A 317
VAL A  12
 None
 0.86A 3d2tA-1hjuA:
undetectable		 3d2tA-1hjuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 9 GLY A 133
GLN A  92
HIS A  81
ASP A  79
ILE A  78
 None
 1.30A 3fi0F-1hjuA:
0.0		 3fi0F-1hjuA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 4 PRO A 298
TYR A 295
GLY A   6
THR A  43
 None
 1.44A 3ib0A-1hjuA:
0.0		 3ib0A-1hjuA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3G_A_TLTA317_1
(ALDOSE REDUCTASE)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 7 TRP A 296
HIS A  81
TRP A  49
TRP A 300
 TRS  A 704 (-3.8A)
None
None
None
 1.01A 3s3gA-1hjuA:
2.3		 3s3gA-1hjuA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 12 GLN A 126
GLY A 124
LEU A  74
ALA A  71
ALA A  72
 None
 1.04A 3sufA-1hjuA:
undetectable		 3sufA-1hjuA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 8 TRP A 296
HIS A  81
TRP A  49
TRP A 300
 TRS  A 704 (-3.8A)
None
None
None
 0.94A 3v35A-1hjuA:
7.3		 3v35A-1hjuA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 7 LEU A 120
ALA A 116
SER A 167
THR A 113
 None
 0.94A 4d7bA-1hjuA:
undetectable		 4d7bA-1hjuA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 6 LEU A 120
ALA A 116
LEU A 169
SER A 167
THR A 113
 None
 1.29A 4i89A-1hjuA:
undetectable		 4i89A-1hjuA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 6 ARG A  47
ASP A  79
ASP A   8
ARG A  45
 None
None
None
TRS  A 704 ( 4.1A)
 1.40A 4kcnA-1hjuA:
0.0		 4kcnA-1hjuA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 6 ARG A  47
ASP A  79
ASP A   8
ARG A  45
 None
None
None
TRS  A 704 ( 4.1A)
 1.40A 4kcnB-1hjuA:
undetectable		 4kcnB-1hjuA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 133
VAL A 211
ARG A  45
ILE A 153
VAL A 195
 None
None
TRS  A 704 ( 4.1A)
None
None
 1.32A 4okwA-1hjuA:
0.0		 4okwA-1hjuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 12 LEU A 179
GLN A 188
LEU A 230
MET A 233
VAL A 291
 None
 1.44A 4okxA-1hjuA:
undetectable		 4okxA-1hjuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 10 ALA A 242
VAL A 243
SER A 286
SER A 285
GLY A 290
 None
 1.28A 4xp1A-1hjuA:
undetectable		 4xp1A-1hjuA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 6 LEU A 120
ALA A 116
LEU A 169
SER A 167
THR A 113
 None
 1.30A 5l4iA-1hjuA:
undetectable		 5l4iA-1hjuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		5 / 12 ILE A 241
GLY A 290
PHE A 294
MET A 233
VAL A 211
 None
 1.28A 5n0xB-1hjuA:
undetectable		 5n0xB-1hjuA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 8 ARG A 137
GLN A 188
TYR A 192
ASP A 180
 None
 0.97A 5vlmB-1hjuA:
undetectable		 5vlmB-1hjuA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1hju BETA-1,4-GALACTANASE
(Thermothelomyces
thermophila) 		4 / 7 THR A 246
HIS A  91
GLU A 135
ASP A 180
 None
None
TRS  A 704 (-2.5A)
None
 1.22A 6mn4E-1hjuA:
0.0		 6mn4E-1hjuA:
20.62