SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hk7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 1hk7 HEAT SHOCK PROTEIN
HSP82
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 491
LEU A 488
SER A 485
THR A 525
 None
 1.27A 1tyrA-1hk7A:
0.1		 1tyrA-1hk7A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 1hk7 HEAT SHOCK PROTEIN
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 513
ARG A 436
ALA A 440
LYS A 441
 None
 0.81A 2xfsA-1hk7A:
0.4		 2xfsA-1hk7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 1hk7 HEAT SHOCK PROTEIN
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 513
ARG A 436
ALA A 440
LYS A 441
 None
 0.82A 2xh9A-1hk7A:
0.0		 2xh9A-1hk7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1hk7 HEAT SHOCK PROTEIN
HSP82
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 474
THR A 525
ASP A 523
THR A 475
VAL A 482
 None
 1.43A 3kpbD-1hk7A:
undetectable		 3kpbD-1hk7A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1hk7 HEAT SHOCK PROTEIN
HSP82
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 289
ILE A 396
LEU A 321
PHE A 322
 None
 1.13A 3ls4L-1hk7A:
undetectable		 3ls4L-1hk7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1hk7 HEAT SHOCK PROTEIN
HSP82
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 317
ILE A 392
PHE A 309
LEU A 362
 None
 0.88A 5hs1A-1hk7A:
undetectable		 5hs1A-1hk7A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1hk7 HEAT SHOCK PROTEIN
HSP82
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 365
ALA A 327
PHE A 417
GLU A 402
ASN A 405
 None
 0.95A 6bqgA-1hk7A:
undetectable		 6bqgA-1hk7A:
15.65