SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hkg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 210
ASN A 408
LEU A  24
VAL A  27
ILE A 411
 None
 1.22A 1claA-1hkgA:
undetectable		 1claA-1hkgA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 137
GLU A 139
GLN A 154
TRP A 109
 None
 1.46A 2aowA-1hkgA:
undetectable		 2aowA-1hkgA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 208
ASN A 198
VAL A 197
ALA A 435
 None
 0.61A 2nniA-1hkgA:
undetectable		 2nniA-1hkgA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		5 / 9 PHE A 210
ASN A 408
LEU A  24
VAL A  27
ILE A 411
 None
 1.38A 3claA-1hkgA:
0.0		 3claA-1hkgA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 431
GLY A 432
ALA A 435
ILE A  79
ILE A  67
 None
 1.07A 3ebzB-1hkgA:
undetectable		 3ebzB-1hkgA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 431
GLY A 432
ALA A 435
ILE A  79
ILE A  67
 None
 1.14A 3s56A-1hkgA:
undetectable		 3s56A-1hkgA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		4 / 7 TRP A  51
PRO A  49
ILE A 225
MET A 240
 None
 1.03A 3u5jA-1hkgA:
undetectable		 3u5jA-1hkgA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 207
HIS A 191
ASP A 189
ILE A 426
ASN A 215
 None
 1.33A 4pooB-1hkgA:
undetectable		 4pooB-1hkgA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		5 / 9 GLN A 246
PHE A 210
GLY A 211
SER A 212
ASN A 284
 None
 1.26A 5entC-1hkgA:
undetectable		 5entC-1hkgA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 111
ASP A  73
GLY A  72
 None
 0.51A 5fctB-1hkgA:
1.0		 5fctB-1hkgA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 133
ILE A 187
PHE A 175
GLY A 434
LEU A  74
 None
 1.17A 5fsaA-1hkgA:
1.2		 5fsaA-1hkgA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 431
GLY A 434
LEU A 133
PHE A 119
ASN A 116
 None
 1.15A 5kc4E-1hkgA:
1.8		 5kc4E-1hkgA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 363
ILE A 362
TYR A 397
ILE A 324
LEU A 289
 None
 1.06A 5mvmA-1hkgA:
0.0
5mvmE-1hkgA:
0.0		 5mvmA-1hkgA:
10.48
5mvmE-1hkgA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1hkg HEXOKINASE A
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 211
LYS A 283
GLY A 207
SER A 190
ILE A 208
 None
 1.10A 5vooB-1hkgA:
undetectable		 5vooB-1hkgA:
19.74