SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hkh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		7 / 10 GLY A  31
MET A  99
LEU A 125
PHE A 162
TRP A 204
LEU A 233
HIS A 259
 None
 0.29A 1a8uA-1hkhA:
48.4		 1a8uA-1hkhA:
68.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		6 / 10 SER A  98
MET A  99
LEU A 125
PHE A 162
TRP A 204
HIS A 259
 None
 0.70A 1a8uA-1hkhA:
48.4		 1a8uA-1hkhA:
68.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		7 / 10 GLY A  31
MET A  99
LEU A 125
PHE A 162
TRP A 204
LEU A 233
HIS A 259
 None
 0.36A 1a8uB-1hkhA:
48.7		 1a8uB-1hkhA:
68.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		6 / 10 SER A  98
MET A  99
LEU A 125
PHE A 162
TRP A 204
HIS A 259
 None
 0.73A 1a8uB-1hkhA:
48.7		 1a8uB-1hkhA:
68.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		5 / 9 PHE A 162
TYR A 163
LEU A  34
GLY A  31
VAL A 200
 None
 1.40A 1dz8A-1hkhA:
0.0		 1dz8A-1hkhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		5 / 9 PHE A 162
TYR A 163
LEU A  34
GLY A  31
VAL A 200
 None
 1.44A 1dz9B-1hkhA:
undetectable		 1dz9B-1hkhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 5 THR A 238
ASP A 230
HIS A 259
HIS A 226
 None
 1.05A 1ei6A-1hkhA:
undetectable		 1ei6A-1hkhA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 8 VAL A 116
VAL A 212
ILE A  29
LEU A 119
 None
 0.90A 1igxA-1hkhA:
undetectable		 1igxA-1hkhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		3 / 3 LYS A 164
ILE A 232
THR A 264
 None
 0.85A 1rx3A-1hkhA:
undetectable		 1rx3A-1hkhA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 5 ALA A 109
TYR A 111
ALA A 105
TYR A 107
 None
 0.93A 1xl6A-1hkhA:
undetectable
1xl6B-1hkhA:
0.0		 1xl6A-1hkhA:
23.55
1xl6B-1hkhA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 4 GLY A  31
SER A  98
ILE A 232
HIS A 259
 None
 1.24A 1yajJ-1hkhA:
12.3		 1yajJ-1hkhA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 7 GLY A  31
SER A  98
PHE A 162
HIS A 259
 None
 0.98A 2ackA-1hkhA:
11.9		 2ackA-1hkhA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		5 / 10 PHE A 162
TYR A 163
LEU A  34
GLY A  31
VAL A 200
 None
 1.37A 2cp4A-1hkhA:
0.0		 2cp4A-1hkhA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		6 / 12 GLY A  62
HIS A  37
ALA A 193
ALA A 197
ALA A 189
PHE A 159
 None
 1.48A 2gluB-1hkhA:
2.7		 2gluB-1hkhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 6 ARG A  59
TYR A  56
THR A  82
ALA A  78
 None
 1.43A 2ql8A-1hkhA:
0.0
2ql8B-1hkhA:
0.0		 2ql8A-1hkhA:
23.05
2ql8B-1hkhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 8 TYR A 163
TYR A 167
SER A 185
SER A  38
 None
 0.88A 2vmyA-1hkhA:
undetectable
2vmyB-1hkhA:
undetectable		 2vmyA-1hkhA:
22.73
2vmyB-1hkhA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 4 ALA A 109
TYR A 111
ALA A 105
TYR A 107
 None
 0.99A 2wlkA-1hkhA:
0.0
2wlkB-1hkhA:
undetectable		 2wlkA-1hkhA:
23.55
2wlkB-1hkhA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		6 / 9 ALA A 120
VAL A  95
GLY A  96
GLY A 100
LEU A 223
LEU A 225
 None
 1.32A 2z0yA-1hkhA:
undetectable		 2z0yA-1hkhA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 7 GLU A 213
SER A 210
VAL A 212
ARG A 241
 None
 1.45A 3dqtA-1hkhA:
0.0
3dqtB-1hkhA:
0.0		 3dqtA-1hkhA:
20.29
3dqtB-1hkhA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		5 / 12 LEU A  15
THR A   4
GLY A   1
ILE A  13
SER A  65
 None
 1.03A 3nk7A-1hkhA:
2.4		 3nk7A-1hkhA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		3 / 3 PHE A  97
TYR A  32
LEU A  94
 None
 0.75A 3sueB-1hkhA:
0.0		 3sueB-1hkhA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 8 LEU A  28
VAL A  95
VAL A  93
GLN A  24
 None
 0.99A 4em2A-1hkhA:
0.0		 4em2A-1hkhA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		3 / 3 LYS A 164
ILE A 232
THR A 264
 None
 0.82A 4gh8A-1hkhA:
undetectable		 4gh8A-1hkhA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 7 GLU A 213
SER A 210
VAL A 212
ARG A 241
 None
 1.46A 4k5jA-1hkhA:
0.0
4k5jB-1hkhA:
0.0		 4k5jA-1hkhA:
19.95
4k5jB-1hkhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 6 GLY A 138
ASP A 207
PRO A 127
ARG A 241
 None
 1.03A 4lajA-1hkhA:
undetectable
4lajB-1hkhA:
undetectable		 4lajA-1hkhA:
19.02
4lajB-1hkhA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		5 / 12 VAL A 195
ALA A 196
TYR A 198
VAL A 200
GLY A  60
 None
 1.15A 4mm4B-1hkhA:
undetectable		 4mm4B-1hkhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		5 / 12 VAL A 200
VAL A 195
PHE A 162
SER A 192
GLY A  60
 None
 1.28A 4mm4B-1hkhA:
undetectable		 4mm4B-1hkhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 7 GLU A 213
SER A 210
VAL A 212
ARG A 241
 None
 1.43A 5adlA-1hkhA:
0.0
5adlB-1hkhA:
0.0		 5adlA-1hkhA:
19.95
5adlB-1hkhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 7 GLU A 213
SER A 210
VAL A 212
ARG A 241
 None
 1.46A 5fj3A-1hkhA:
0.0
5fj3B-1hkhA:
0.0		 5fj3A-1hkhA:
19.95
5fj3B-1hkhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 6 SER A  65
GLY A   6
ASN A   7
ILE A   3
 None
 0.95A 5j4nA-1hkhA:
undetectable		 5j4nA-1hkhA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 7 LEU A 223
THR A 228
ASP A 230
LEU A 273
 None
 0.89A 5jq7B-1hkhA:
undetectable		 5jq7B-1hkhA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 8 ASP A 230
HIS A 259
ARG A 241
HIS A 226
 None
 0.90A 5nekB-1hkhA:
undetectable		 5nekB-1hkhA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 8 ASP A 230
HIS A 259
ARG A 241
HIS A 226
 None
 0.84A 5nekD-1hkhA:
undetectable		 5nekD-1hkhA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		5 / 12 LEU A  94
ALA A 120
ILE A  29
GLY A 100
LEU A 277
 None
 1.05A 5nfjB-1hkhA:
undetectable		 5nfjB-1hkhA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		5 / 12 LEU A  94
ALA A 120
ILE A  29
GLY A 100
LEU A 277
 None
 1.03A 5nfjC-1hkhA:
undetectable		 5nfjC-1hkhA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 7 GLU A 213
SER A 210
VAL A 212
ARG A 241
 None
 1.47A 5vv7A-1hkhA:
0.0
5vv7B-1hkhA:
0.0		 5vv7A-1hkhA:
19.95
5vv7B-1hkhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 7 GLU A 213
SER A 210
VAL A 212
ARG A 241
 None
 1.42A 5vvnA-1hkhA:
0.0
5vvnB-1hkhA:
0.0		 5vvnA-1hkhA:
19.95
5vvnB-1hkhA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 5 ALA A 197
SER A 192
GLY A  60
TYR A  71
 None
 1.21A 5yodB-1hkhA:
0.0		 5yodB-1hkhA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		6 / 10 VAL A  95
LEU A 122
LEU A 262
LEU A  46
THR A  55
LEU A 273
 None
 1.09A 6f5uA-1hkhA:
0.0
6f5uB-1hkhA:
undetectable		 6f5uA-1hkhA:
15.97
6f5uB-1hkhA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1hkh GAMMA LACTAMASE
(Microbacterium) 		4 / 6 LEU A 125
THR A 101
GLY A 100
ARG A  58
 None
 1.27A 6gtqB-1hkhA:
0.0
6gtqD-1hkhA:
undetectable		 6gtqB-1hkhA:
19.78
6gtqD-1hkhA:
10.09