SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hkk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 9 TYR A  27
PHE A  58
GLY A  98
ASP A 138
MET A 210
ASP A 213
TRP A 358
 AMI  A1388 (-3.6A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.1A)
AMI  A1388 (-3.3A)
AMI  A1388 ( 2.9A)
AMI  A1388 (-3.5A)
 1.06A 1e9lA-1hkkA:
58.2		 1e9lA-1hkkA:
48.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1E9L_A_GCSA800_1
(YM1 SECRETORY
PROTEIN)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 9 TYR A  27
PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
ASP A 213
 AMI  A1388 (-3.6A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.1A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
 0.90A 1e9lA-1hkkA:
58.2		 1e9lA-1hkkA:
48.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 5 LEU A 158
THR A 157
ARG A 116
VAL A 120
 None
 1.09A 1ekjF-1hkkA:
undetectable
1ekjG-1hkkA:
1.4		 1ekjF-1hkkA:
21.11
1ekjG-1hkkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 6 TYR A 195
GLY A 194
GLY A 187
SER A 144
 None
None
AMI  A1391 (-3.3A)
AMI  A1391 ( 4.9A)
 0.99A 1eswA-1hkkA:
4.7		 1eswA-1hkkA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 GLU A 169
ILE A 124
LEU A 135
GLY A 134
ALA A  59
 None
 1.16A 1hvyA-1hkkA:
0.0		 1hvyA-1hkkA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 8 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.90A 1v54P-1hkkA:
0.3
1v54W-1hkkA:
undetectable		 1v54P-1hkkA:
21.66
1v54W-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.92A 1v55C-1hkkA:
0.1
1v55J-1hkkA:
0.0		 1v55C-1hkkA:
21.66
1v55J-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.97A 1v55P-1hkkA:
0.1
1v55W-1hkkA:
0.0		 1v55P-1hkkA:
21.66
1v55W-1hkkA:
12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1433_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 11 PHE A  58
GLY A  98
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 358
 AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.1A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.91A 2a3aA-1hkkA:
14.0		 2a3aA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1433_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		9 / 11 TYR A  27
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
 AMI  A1388 (-3.6A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.73A 2a3aA-1hkkA:
14.0		 2a3aA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1433_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		8 / 11 TYR A  27
PHE A  58
GLY A  98
TRP A  99
GLU A 140
MET A 210
TYR A 212
TRP A 358
 AMI  A1388 (-3.6A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
NAA  A1390 ( 4.3A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 0.81A 2a3aA-1hkkA:
14.0		 2a3aA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_A_TEPA1435_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		3 / 3 TRP A  99
GLU A 140
TYR A 141
 NAA  A1390 ( 4.3A)
AMI  A1388 ( 3.3A)
NAA  A1390 (-4.5A)
 0.48A 2a3aA-1hkkA:
14.0		 2a3aA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3A_B_TEPB2433_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		8 / 9 PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
 AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.56A 2a3aB-1hkkA:
43.9		 2a3aB-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_A_CFFA1435_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		8 / 11 TYR A  27
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
 AMI  A1388 (-3.6A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.74A 2a3bA-1hkkA:
43.8		 2a3bA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2435_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		6 / 10 PHE A  58
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 358
 AMI  A1388 (-4.8A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 1.10A 2a3bB-1hkkA:
14.0		 2a3bB-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2435_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		6 / 10 PHE A  58
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 358
 AMI  A1388 (-4.8A)
AMI  A1388 (-3.1A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.97A 2a3bB-1hkkA:
14.0		 2a3bB-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2435_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		6 / 10 PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 358
 AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 0.78A 2a3bB-1hkkA:
14.0		 2a3bB-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3B_B_CFFB2435_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 10 PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
 AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.48A 2a3bB-1hkkA:
14.0		 2a3bB-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 12 TRP A  31
PHE A  58
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 358
 NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 1.17A 2a3cA-1hkkA:
13.9		 2a3cA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		8 / 12 TYR A  27
TRP A  31
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 358
 AMI  A1388 (-3.6A)
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 0.98A 2a3cA-1hkkA:
13.9		 2a3cA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_A_PNXA1434_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		9 / 12 TYR A  27
TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
 AMI  A1388 (-3.6A)
NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.73A 2a3cA-1hkkA:
13.9		 2a3cA-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 12 TRP A  31
PHE A  58
ASP A 138
GLU A 140
MET A 210
TYR A 212
TRP A 358
 NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 1.12A 2a3cB-1hkkA:
43.9		 2a3cB-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 12 TRP A  31
PHE A  58
ASP A 138
MET A 210
TYR A 212
TYR A 267
TRP A 358
 NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.1A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.96A 2a3cB-1hkkA:
43.9		 2a3cB-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 12 TRP A  31
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
TRP A 358
 NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 0.81A 2a3cB-1hkkA:
43.9		 2a3cB-1hkkA:
30.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A3C_B_PNXB2433_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		8 / 12 TRP A  31
PHE A  58
GLY A  98
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
 NAA  A1386 (-4.0A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.51A 2a3cB-1hkkA:
43.9		 2a3cB-1hkkA:
30.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 GLY A 351
GLY A 354
GLY A 353
ALA A 257
ASP A 335
 None
 1.14A 2dpmA-1hkkA:
undetectable		 2dpmA-1hkkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 1.02A 2dysC-1hkkA:
0.3
2dysJ-1hkkA:
0.0		 2dysC-1hkkA:
21.66
2dysJ-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.94A 2dysP-1hkkA:
undetectable
2dysW-1hkkA:
0.0		 2dysP-1hkkA:
21.66
2dysW-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.96A 2eijC-1hkkA:
undetectable
2eijJ-1hkkA:
0.0		 2eijC-1hkkA:
21.66
2eijJ-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.89A 2eijP-1hkkA:
0.1
2eijW-1hkkA:
0.0		 2eijP-1hkkA:
21.66
2eijW-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.88A 2eikC-1hkkA:
undetectable
2eikJ-1hkkA:
0.0		 2eikC-1hkkA:
21.66
2eikJ-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 8 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.88A 2eikP-1hkkA:
undetectable
2eikW-1hkkA:
undetectable		 2eikP-1hkkA:
21.66
2eikW-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 8 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.89A 2eilC-1hkkA:
undetectable
2eilJ-1hkkA:
undetectable		 2eilC-1hkkA:
21.66
2eilJ-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 8 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.87A 2eilP-1hkkA:
0.3
2eilW-1hkkA:
0.0		 2eilP-1hkkA:
21.66
2eilW-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.90A 2eimC-1hkkA:
0.3
2eimJ-1hkkA:
0.0		 2eimC-1hkkA:
21.66
2eimJ-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.96A 2einC-1hkkA:
0.3
2einJ-1hkkA:
0.0		 2einC-1hkkA:
21.66
2einJ-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 VAL A 243
SER A 226
LEU A 347
PHE A 340
 None
 1.05A 2f78A-1hkkA:
0.0		 2f78A-1hkkA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 9 LEU A 137
ILE A  96
GLY A  97
GLY A  98
LEU A  93
 None
None
None
AMI  A1388 ( 3.7A)
None
 1.16A 2qmmA-1hkkA:
undetectable		 2qmmA-1hkkA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 8 ILE A 325
LEU A 301
GLY A 268
PHE A 334
 None
 0.85A 2tsrB-1hkkA:
undetectable		 2tsrB-1hkkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UY4_A_AZMA1311_1
(ENDOCHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 9 TYR A  27
PHE A  58
GLY A  98
ASP A 138
GLU A 140
TYR A 212
TRP A 358
 AMI  A1388 (-3.6A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 0.57A 2uy4A-1hkkA:
19.5		 2uy4A-1hkkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_A_AZMA1339_1
(CLASS III CHITINASE
CHIA1)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 11 TYR A  27
PHE A  58
GLY A  98
ASP A 138
GLU A 140
TYR A 212
TRP A 358
 AMI  A1388 (-3.6A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 0.82A 2xtkA-1hkkA:
20.4		 2xtkA-1hkkA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		7 / 10 TYR A  27
PHE A  58
GLY A  98
ASP A 138
GLU A 140
TYR A 212
TRP A 358
 AMI  A1388 (-3.6A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 (-3.5A)
 0.71A 2xtkB-1hkkA:
20.6		 2xtkB-1hkkA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 1.00A 2zxwC-1hkkA:
0.1
2zxwJ-1hkkA:
0.0		 2zxwC-1hkkA:
21.66
2zxwJ-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 6 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.99A 2zxwP-1hkkA:
0.1
2zxwW-1hkkA:
0.0		 2zxwP-1hkkA:
21.66
2zxwW-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.86A 3ag2P-1hkkA:
undetectable
3ag2W-1hkkA:
0.0		 3ag2P-1hkkA:
21.66
3ag2W-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 8 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.93A 3ag4C-1hkkA:
undetectable
3ag4J-1hkkA:
0.0		 3ag4C-1hkkA:
21.66
3ag4J-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.89A 3ag4P-1hkkA:
0.4
3ag4W-1hkkA:
undetectable		 3ag4P-1hkkA:
21.66
3ag4W-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 9 LEU A 137
ILE A  96
GLY A  97
LEU A 180
LEU A  93
 None
 1.07A 3ai9X-1hkkA:
undetectable		 3ai9X-1hkkA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARQ_A_DM5A606_1
(CHITINASE A)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 6 TRP A  99
ASP A 213
TRP A 218
ARG A 269
 NAA  A1390 ( 4.3A)
AMI  A1388 ( 2.9A)
NAA  A1390 (-3.2A)
NAA  A1389 (-3.2A)
 0.42A 3arqA-1hkkA:
41.3		 3arqA-1hkkA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 7 TRP A  99
GLY A 187
ASP A 213
TRP A 218
ARG A 269
 NAA  A1390 ( 4.3A)
AMI  A1391 (-3.3A)
AMI  A1388 ( 2.9A)
NAA  A1390 (-3.2A)
NAA  A1389 (-3.2A)
 0.60A 3arrA-1hkkA:
42.2		 3arrA-1hkkA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 GLY A 187
ASP A 213
TRP A 218
ARG A 269
 AMI  A1391 (-3.3A)
AMI  A1388 ( 2.9A)
NAA  A1390 (-3.2A)
NAA  A1389 (-3.2A)
 0.34A 3aruA-1hkkA:
42.1		 3aruA-1hkkA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 5 GLN A 372
ASP A 363
ASP A 335
THR A 380
 None
 1.25A 3bwcB-1hkkA:
1.4		 3bwcB-1hkkA:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G6M_A_CFFA1_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		9 / 11 PHE A  58
GLY A  98
TRP A  99
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
 AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
NAA  A1390 ( 4.3A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.72A 3g6mA-1hkkA:
44.6		 3g6mA-1hkkA:
33.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G6M_A_CFFA1_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		9 / 11 TYR A  27
PHE A  58
GLY A  98
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
TRP A 358
 AMI  A1388 (-3.6A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
AMI  A1388 (-3.5A)
 0.79A 3g6mA-1hkkA:
44.6		 3g6mA-1hkkA:
33.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G6M_A_CFFA427_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 5 TRP A  99
TYR A 141
MET A 210
ASP A 213
TRP A 218
 NAA  A1390 ( 4.3A)
NAA  A1390 (-4.5A)
AMI  A1388 (-3.3A)
AMI  A1388 ( 2.9A)
NAA  A1390 (-3.2A)
 0.84A 3g6mA-1hkkA:
44.6		 3g6mA-1hkkA:
33.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 8 ASP A 136
TYR A  27
VAL A 207
LEU A 260
 AMI  A1388 ( 4.9A)
AMI  A1388 (-3.6A)
None
None
 1.09A 3jq7C-1hkkA:
2.3		 3jq7C-1hkkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 10 ILE A  96
ASN A 115
LEU A 137
LEU A 158
VAL A 110
 None
ZN  A1393 (-4.0A)
None
None
None
 1.23A 3o02A-1hkkA:
0.0
3o02B-1hkkA:
0.0		 3o02A-1hkkA:
22.19
3o02B-1hkkA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_A_ADNA901_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 9 ALA A 355
GLY A 263
LEU A 352
LEU A 209
ASN A 208
 None
 1.14A 3wdmA-1hkkA:
undetectable		 3wdmA-1hkkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 9 ALA A 355
GLY A 263
LEU A 352
LEU A 209
ASN A 208
 None
 1.15A 3wdmC-1hkkA:
undetectable		 3wdmC-1hkkA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WQV_A_GCSA501_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		11 / 11 PHE A  58
GLY A  98
TRP A  99
ASP A 138
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
ARG A 269
TRP A 358
 AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
NAA  A1390 ( 4.3A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
NAA  A1389 (-3.2A)
AMI  A1388 (-3.5A)
 0.47A 3wqvA-1hkkA:
55.2		 3wqvA-1hkkA:
39.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WQW_A_GCSA501_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		11 / 11 PHE A  58
GLY A  98
TRP A  99
ASP A 138
GLU A 140
MET A 210
TYR A 212
ASP A 213
TYR A 267
ARG A 269
TRP A 358
 AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
NAA  A1390 ( 4.3A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1387 (-3.6A)
NAA  A1389 (-3.2A)
AMI  A1388 (-3.5A)
 0.50A 3wqwA-1hkkA:
55.2		 3wqwA-1hkkA:
39.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.83A 3x2qC-1hkkA:
undetectable
3x2qJ-1hkkA:
0.0		 3x2qC-1hkkA:
21.66
3x2qJ-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.82A 3x2qP-1hkkA:
undetectable
3x2qW-1hkkA:
undetectable		 3x2qP-1hkkA:
21.66
3x2qW-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 PHE A 126
LEU A 135
GLY A 134
PHE A 132
ALA A 182
 None
 1.25A 4eb4A-1hkkA:
0.0		 4eb4A-1hkkA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 PHE A 126
LEU A 135
GLY A 134
PHE A 132
ALA A 182
 None
 1.26A 4eb4B-1hkkA:
0.0		 4eb4B-1hkkA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 8 ASP A 213
ASP A 138
ASP A 136
ASN A 100
 AMI  A1388 ( 2.9A)
AMI  A1388 (-3.1A)
AMI  A1388 ( 4.9A)
NAA  A1387 (-3.9A)
 1.07A 4feuD-1hkkA:
0.0		 4feuD-1hkkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 ILE A 325
LEU A 301
GLY A 268
PHE A 334
 None
 0.90A 4iqqA-1hkkA:
undetectable		 4iqqA-1hkkA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 8 ILE A 325
LEU A 301
GLY A 268
PHE A 334
 None
 0.89A 4iqqD-1hkkA:
undetectable		 4iqqD-1hkkA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 8 PHE A 271
TRP A 331
PRO A 227
GLN A 320
 None
 1.15A 4j7uD-1hkkA:
undetectable		 4j7uD-1hkkA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 5 LEU A 127
SER A 122
LEU A 162
LEU A  94
 None
 1.22A 4n09B-1hkkA:
undetectable		 4n09B-1hkkA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 5 LEU A 127
SER A 122
LEU A 162
LEU A  94
 None
 1.22A 4n09D-1hkkA:
3.6		 4n09D-1hkkA:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4NSB_A_AINA402_1
(CHITINASE-3-LIKE
PROTEIN 1)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 7 THR A  29
TRP A  31
ARG A  35
TRP A 358
LEU A 362
 None
NAA  A1386 (-4.0A)
None
AMI  A1388 (-3.5A)
None
 0.45A 4nsbA-1hkkA:
55.4		 4nsbA-1hkkA:
50.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 5 ASP A  73
LEU A  76
ARG A  40
THR A  68
 None
 1.26A 4p3qA-1hkkA:
undetectable		 4p3qA-1hkkA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		3 / 3 LEU A 360
MET A 356
TYR A 303
 None
AMI  A1388 (-4.0A)
None
 0.96A 4p6xG-1hkkA:
0.0		 4p6xG-1hkkA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 ASP A 244
LEU A 352
LEU A 262
GLY A 263
PHE A 214
 None
 1.39A 4pfjB-1hkkA:
undetectable		 4pfjB-1hkkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 ASP A 244
LEU A 352
LEU A 262
GLY A 263
PHE A 214
 None
 1.37A 4pgfB-1hkkA:
undetectable		 4pgfB-1hkkA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.86A 5b1aC-1hkkA:
0.3
5b1aJ-1hkkA:
0.0		 5b1aC-1hkkA:
21.66
5b1aJ-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.82A 5b1aP-1hkkA:
0.3
5b1aW-1hkkA:
0.0		 5b1aP-1hkkA:
21.66
5b1aW-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.83A 5b3sC-1hkkA:
0.3
5b3sJ-1hkkA:
0.0		 5b3sC-1hkkA:
21.66
5b3sJ-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 ALA A 111
LEU A 137
ILE A  55
GLY A 134
LEU A  66
 None
 1.04A 5fsaA-1hkkA:
undetectable		 5fsaA-1hkkA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		3 / 3 TRP A  99
GLU A 140
ASP A 213
 NAA  A1390 ( 4.3A)
AMI  A1388 ( 3.3A)
AMI  A1388 ( 2.9A)
 0.35A 5gqbA-1hkkA:
44.5		 5gqbA-1hkkA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		8 / 8 PHE A  58
GLY A  98
TRP A  99
GLU A 140
TYR A 212
ASP A 213
ARG A 269
TRP A 358
 AMI  A1388 (-4.8A)
AMI  A1388 ( 3.7A)
NAA  A1390 ( 4.3A)
AMI  A1388 ( 3.3A)
AMI  A1388 (-4.8A)
AMI  A1388 ( 2.9A)
NAA  A1389 (-3.2A)
AMI  A1388 (-3.5A)
 0.53A 5gqbA-1hkkA:
44.5		 5gqbA-1hkkA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		4 / 7 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.84A 5iy5C-1hkkA:
0.1
5iy5J-1hkkA:
0.0		 5iy5C-1hkkA:
21.35
5iy5J-1hkkA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 ILE A  55
PHE A 106
GLY A 134
LEU A  66
PHE A 101
 None
 1.28A 5v5zA-1hkkA:
undetectable		 5v5zA-1hkkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 SER A 258
GLY A 354
ALA A 355
PHE A 206
SER A 181
 None
 1.26A 5wbvA-1hkkA:
0.0		 5wbvA-1hkkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 SER A 258
GLY A 354
ALA A 355
PHE A 206
SER A 181
 None
 1.27A 5wbvB-1hkkA:
0.0		 5wbvB-1hkkA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 VAL A 243
ASP A 244
LEU A 385
SER A 226
LEU A 381
 None
 1.18A 6ew0F-1hkkA:
undetectable		 6ew0F-1hkkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 1hkk CHITOTRIOSIDASE-1
(Homo
sapiens) 		5 / 12 VAL A 243
ASP A 244
LEU A 385
SER A 226
LEU A 381
 None
 1.18A 6ew0G-1hkkA:
undetectable		 6ew0G-1hkkA:
15.81