SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hkt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 1hkt HEAT-SHOCK
TRANSCRIPTION FACTOR
(Drosophila
melanogaster) 		3 / 3 TRP A  68
ALA A  60
VAL A  57
 None
 0.94A 1av2C-1hktA:
undetectable
1av2D-1hktA:
undetectable		 1av2C-1hktA:
17.02
1av2D-1hktA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 1hkt HEAT-SHOCK
TRANSCRIPTION FACTOR
(Drosophila
melanogaster) 		4 / 8 TYR A  92
PHE A 100
THR A  62
LEU A  56
 None
 1.28A 1ea1A-1hktA:
0.0		 1ea1A-1hktA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 1hkt HEAT-SHOCK
TRANSCRIPTION FACTOR
(Drosophila
melanogaster) 		3 / 3 ALA A  60
VAL A  57
TRP A  68
 None
 1.00A 1gmkC-1hktA:
undetectable
1gmkD-1hktA:
undetectable		 1gmkC-1hktA:
17.02
1gmkD-1hktA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 1hkt HEAT-SHOCK
TRANSCRIPTION FACTOR
(Drosophila
melanogaster) 		3 / 3 TRP A  68
ALA A  60
VAL A  57
 None
 0.97A 1w5uA-1hktA:
undetectable
1w5uB-1hktA:
undetectable		 1w5uA-1hktA:
17.02
1w5uB-1hktA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 1hkt HEAT-SHOCK
TRANSCRIPTION FACTOR
(Drosophila
melanogaster) 		3 / 3 ALA A  60
VAL A  57
TRP A  68
 None
 0.87A 2izqA-1hktA:
undetectable
2izqB-1hktA:
undetectable		 2izqA-1hktA:
17.02
2izqB-1hktA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 1hkt HEAT-SHOCK
TRANSCRIPTION FACTOR
(Drosophila
melanogaster) 		3 / 3 TRP A  68
ALA A  60
VAL A  57
 None
 0.93A 3l8lA-1hktA:
undetectable
3l8lB-1hktA:
undetectable		 3l8lA-1hktA:
17.02
3l8lB-1hktA:
17.02