SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 302
GLY A 309
ARG A 303
GLY A 403
 SO4  A 500 (-3.7A)
None
SO4  A 500 (-3.3A)
None
 0.73A 1jhqA-1hkwA:
undetectable		 1jhqA-1hkwA:
22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TUF_A_AZ1A502_1
(DIAMINOPIMELATE
DECARBOXYLASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A 215
SER A 216
ARG A 303
ARG A 344
TYR A 348
 None
None
SO4  A 500 (-3.3A)
None
None
 1.19A 1tufA-1hkwA:
46.0
1tufB-1hkwA:
46.0		 1tufA-1hkwA:
31.60
1tufB-1hkwA:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A  41
GLY A 337
TYR A 314
 None
 0.56A 2vouA-1hkwA:
0.1		 2vouA-1hkwA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A  41
GLY A 337
TYR A 314
 None
 0.56A 2vouB-1hkwA:
0.2		 2vouB-1hkwA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A  41
GLY A 337
TYR A 314
 None
 0.57A 2vouC-1hkwA:
0.0		 2vouC-1hkwA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 344
ARG A 303
ILE A 261
TYR A 352
 None
SO4  A 500 (-3.3A)
None
None
 1.23A 2yfbB-1hkwA:
undetectable		 2yfbB-1hkwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A  26
ILE A 261
TYR A 263
LEU A  31
 None
 1.13A 3adsA-1hkwA:
0.0		 3adsA-1hkwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 255
SER A 212
VAL A 164
ALA A 168
 None
 0.98A 3ax9A-1hkwA:
0.0		 3ax9A-1hkwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 6 ALA A  99
LEU A 102
ALA A 125
THR A 124
 None
 0.90A 3b6hB-1hkwA:
undetectable		 3b6hB-1hkwA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A  32
VAL A 316
LEU A 370
SER A 361
VAL A 333
 None
 1.35A 3frqA-1hkwA:
0.0		 3frqA-1hkwA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 316
TYR A 314
LEU A 370
SER A 361
VAL A 333
 None
 1.17A 3frqA-1hkwA:
0.0		 3frqA-1hkwA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		6 / 10 LYS A  72
HIS A 213
GLY A 215
ARG A 303
TYR A 405
LEU A 409
 None
None
None
SO4  A 500 (-3.3A)
SO4  A 500 (-4.3A)
None
 0.82A 3n2oC-1hkwA:
27.8
3n2oD-1hkwA:
27.9		 3n2oC-1hkwA:
24.92
3n2oD-1hkwA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 396
GLN A  36
THR A  32
GLU A 315
 None
 1.31A 3n58C-1hkwA:
2.0		 3n58C-1hkwA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 4 GLY A 240
GLY A 243
THR A 247
LEU A 292
 None
 0.86A 3si7C-1hkwA:
0.0
3si7D-1hkwA:
0.0		 3si7C-1hkwA:
21.29
3si7D-1hkwA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 11 THR A 312
LEU A 370
SER A 340
THR A 345
PHE A  43
 None
 1.42A 3tbgA-1hkwA:
0.0		 3tbgA-1hkwA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 148
LEU A 145
VAL A 131
GLY A 130
 None
 0.73A 3w1wA-1hkwA:
4.4		 3w1wA-1hkwA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 117
GLY A 115
ILE A 134
LEU A 123
 None
 0.91A 4ejjD-1hkwA:
0.0		 4ejjD-1hkwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 7 PRO A  41
ASP A 341
HIS A 374
SER A 340
 None
 1.23A 4k7gB-1hkwA:
0.0		 4k7gB-1hkwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 8 ALA A  71
GLU A  97
GLY A  96
VAL A 131
 None
 0.81A 4r20A-1hkwA:
undetectable		 4r20A-1hkwA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 8 THR A 202
ILE A 154
VAL A 120
LEU A 123
 None
 1.01A 4r38B-1hkwA:
undetectable		 4r38B-1hkwA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A  42
ASP A 341
ILE A  26
 None
 0.64A 4xi3D-1hkwA:
undetectable		 4xi3D-1hkwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 ASN A  66
VAL A  67
GLY A 256
ILE A 214
HIS A 213
 None
 1.37A 4xucA-1hkwA:
undetectable		 4xucA-1hkwA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  67
GLY A 256
ILE A 214
GLN A 181
HIS A 213
 None
 1.24A 4xucA-1hkwA:
undetectable		 4xucA-1hkwA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  67
GLY A 256
ILE A 214
GLN A 181
HIS A 213
 None
 1.25A 4xudA-1hkwA:
undetectable		 4xudA-1hkwA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 297
LEU A 234
ILE A 232
VAL A 160
LEU A 207
 None
 0.92A 4y0pA-1hkwA:
undetectable		 4y0pA-1hkwA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 297
VAL A 283
ILE A 282
LEU A 259
LEU A 275
 None
 1.20A 4yvpB-1hkwA:
6.8		 4yvpB-1hkwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 154
VAL A 196
ILE A 142
PHE A 200
 None
 0.98A 5hieC-1hkwA:
0.0		 5hieC-1hkwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL A  79
ILE A 305
ASN A 342
PHE A  74
 None
 0.87A 5hieC-1hkwA:
0.0		 5hieC-1hkwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 149
ILE A 148
ILE A 134
ALA A 126
LEU A 123
 None
 1.04A 5mvmA-1hkwA:
undetectable
5mvmE-1hkwA:
0.0		 5mvmA-1hkwA:
10.87
5mvmE-1hkwA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 430
PHE A  43
LEU A 433
LEU A  34
 None
 1.11A 5veuH-1hkwA:
0.0		 5veuH-1hkwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 141
LEU A 145
GLN A 156
LEU A 113
 None
 1.20A 5yvnA-1hkwA:
undetectable		 5yvnA-1hkwA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  28
ALA A  27
ASP A  48
VAL A 422
VAL A 424
 None
 0.92A 6dh0B-1hkwA:
undetectable		 6dh0B-1hkwA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  43
LEU A 433
PHE A  74
GLY A 403
ILE A 381
 None
 1.33A 6dwnA-1hkwA:
undetectable		 6dwnA-1hkwA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 166
LEU A 275
ASP A 220
ALA A 227
LEU A 279
 None
 1.09A 6ew0F-1hkwA:
undetectable		 6ew0F-1hkwA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		4 / 4 ARG A  81
GLU A  85
GLU A  47
ARG A  51
 None
 1.20A 6fk2A-1hkwA:
undetectable		 6fk2A-1hkwA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 1hkw DIAMINOPIMELATE
DECARBOXYLASE
(Mycobacterium
tuberculosis) 		5 / 9 GLY A 257
GLY A 256
TYR A 405
HIS A 114
VAL A 135
 SO4  A 500 ( 3.9A)
None
SO4  A 500 (-4.3A)
None
None
 1.26A 6gnfA-1hkwA:
undetectable		 6gnfA-1hkwA:
21.89