SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Mus
musculus) 		5 / 11 ARG A 346
ILE A 350
ILE A 429
HIS A 420
MET A 422
 DTT  A1475 ( 3.7A)
None
None
None
None
 1.20A 2azyA-1hkxA:
undetectable		 2azyA-1hkxA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Mus
musculus) 		4 / 8 ALA A 379
ALA A 384
GLU A 383
LEU A 392
 None
 0.78A 2bxgA-1hkxA:
undetectable		 2bxgA-1hkxA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Mus
musculus) 		4 / 6 ALA A 360
ASP A 365
ARG A 433
MET A 377
 None
 1.12A 2ouzA-1hkxA:
undetectable		 2ouzA-1hkxA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Mus
musculus) 		3 / 3 PRO A 375
LEU A 392
ARG A 396
 None
 0.91A 3aqiA-1hkxA:
undetectable		 3aqiA-1hkxA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Mus
musculus) 		3 / 3 PRO A 375
LEU A 392
ARG A 396
 None
 0.83A 3aqiB-1hkxA:
undetectable		 3aqiB-1hkxA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Mus
musculus) 		4 / 6 ILE A 350
TYR A 431
ILE A 464
HIS A 456
 None
 0.81A 3eteA-1hkxA:
undetectable
3eteE-1hkxA:
undetectable		 3eteA-1hkxA:
14.97
3eteE-1hkxA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Mus
musculus) 		4 / 5 ILE A 350
TYR A 431
ILE A 464
HIS A 456
 None
 0.81A 3eteB-1hkxA:
undetectable
3eteC-1hkxA:
undetectable		 3eteB-1hkxA:
14.97
3eteC-1hkxA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Mus
musculus) 		4 / 7 ILE A 464
HIS A 456
ILE A 350
TYR A 431
 None
 0.82A 3eteD-1hkxA:
undetectable
3eteF-1hkxA:
undetectable		 3eteD-1hkxA:
14.97
3eteF-1hkxA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Mus
musculus) 		5 / 12 TYR A 369
GLU A 355
ILE A 350
ILE A 414
GLU A 451
 None
 1.43A 4a99A-1hkxA:
undetectable
4a99C-1hkxA:
undetectable		 4a99A-1hkxA:
16.32
4a99C-1hkxA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1hkx CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN
(Mus
musculus) 		4 / 7 ILE A 351
HIS A 420
LEU A 421
ALA A 427
 None
None
TBR  A2000 (-3.9A)
None
 0.98A 5hrqE-1hkxA:
undetectable
5hrqF-1hkxA:
undetectable
5hrqJ-1hkxA:
undetectable		 5hrqE-1hkxA:
16.00
5hrqF-1hkxA:
13.91
5hrqJ-1hkxA:
13.91