SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 12 ILE A 247
GLU A 192
ILE A 212
ASN A 211
LEU A 255
 None
 1.20A 1dlsA-1hl2A:
undetectable		 1dlsA-1hl2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.27A 1hrkB-1hl2A:
2.1		 1hrkB-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 11 LEU A  12
LEU A  63
ALA A 129
VAL A  66
LEU A  76
 None
 1.24A 1kt6A-1hl2A:
0.0		 1kt6A-1hl2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 11 LEU A  12
LEU A  63
ALA A 129
VAL A  66
LEU A  76
 None
 1.20A 1kt7A-1hl2A:
0.0		 1kt7A-1hl2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 8 TYR A 190
GLU A 192
SER A 208
TYR A 210
 None
 1.27A 1nx9A-1hl2A:
undetectable		 1nx9A-1hl2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 8 TYR A 190
GLU A 192
SER A 208
TYR A 210
 None
 1.25A 1nx9B-1hl2A:
undetectable		 1nx9B-1hl2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 8 TYR A 190
GLU A 192
SER A 208
TYR A 210
 None
 1.25A 1nx9C-1hl2A:
undetectable		 1nx9C-1hl2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 8 TYR A 190
GLU A 192
SER A 208
TYR A 210
 None
 1.27A 1nx9D-1hl2A:
undetectable		 1nx9D-1hl2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		6 / 12 ALA A  10
GLY A  46
GLY A  45
LEU A  12
LEU A  13
LEU A  22
 None
3PY  A 802 (-3.5A)
None
None
None
None
 1.36A 1ya4A-1hl2A:
undetectable		 1ya4A-1hl2A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 12 TYR A 187
VAL A 185
ASP A 203
ASN A   4
GLY A  41
 None
 1.18A 2dcfA-1hl2A:
0.0		 2dcfA-1hl2A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 264
VAL A  31
ASP A 191
 None
 0.77A 2fumD-1hl2A:
undetectable		 2fumD-1hl2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.16A 2hrcA-1hl2A:
0.2		 2hrcA-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.26A 2hrcB-1hl2A:
2.1		 2hrcB-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 5 VAL A 106
THR A 107
VAL A 145
GLY A 144
 None
 1.15A 2p2fA-1hl2A:
undetectable		 2p2fA-1hl2A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 4 VAL A 106
THR A 107
VAL A 145
GLY A 144
 None
 1.18A 2p2fB-1hl2A:
undetectable		 2p2fB-1hl2A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.27A 2pnjB-1hl2A:
2.2		 2pnjB-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.48A 2qd2A-1hl2A:
undetectable		 2qd2A-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 9 PHE A 100
TYR A  98
ALA A  78
THR A  14
LEU A  22
 None
 1.22A 2wv2A-1hl2A:
0.0		 2wv2A-1hl2A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WV2_A_TPFA1_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 9 PHE A 100
TYR A  98
ALA A  78
THR A  14
LEU A  27
 None
 1.22A 2wv2A-1hl2A:
0.0		 2wv2A-1hl2A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A 100
TYR A  98
ALA A  78
THR A  14
 None
 0.61A 2wx2A-1hl2A:
undetectable		 2wx2A-1hl2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 8 PHE A 100
TYR A  98
ALA A  78
THR A  14
 None
 0.70A 2wx2B-1hl2A:
undetectable		 2wx2B-1hl2A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 10 TYR A  43
TYR A 137
SER A  47
GLY A 189
ILE A 206
 3PY  A 802 (-4.6A)
3PY  A 802 (-4.0A)
3PY  A 802 (-3.2A)
None
3PY  A 802 ( 4.9A)
 1.28A 2zm8A-1hl2A:
0.0		 2zm8A-1hl2A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1R_B_FITB327_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 11 TYR A 210
ILE A 220
TYR A 217
ARG A 178
MET A 174
 None
 1.13A 3g1rB-1hl2A:
10.4		 3g1rB-1hl2A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 4 LEU A 282
PRO A 283
LEU A 285
ARG A 253
 None
 1.22A 3hcoB-1hl2A:
2.2		 3hcoB-1hl2A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 8 PHE A 100
ALA A  78
THR A  14
LEU A  27
 None
 0.97A 3khmA-1hl2A:
undetectable		 3khmA-1hl2A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 8 PHE A 100
TYR A  98
ALA A  78
THR A  14
 None
 0.77A 3khmA-1hl2A:
undetectable		 3khmA-1hl2A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A  49
GLY A  45
GLN A  54
LEU A  13
SER A 208
 None
 1.11A 3kkzA-1hl2A:
undetectable		 3kkzA-1hl2A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 8 PHE A 100
ALA A  78
THR A  14
LEU A  27
 None
 0.92A 3l4dA-1hl2A:
undetectable		 3l4dA-1hl2A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 7 TYR A 187
VAL A 145
ILE A 152
ARG A 142
 None
 1.27A 3ms9B-1hl2A:
undetectable		 3ms9B-1hl2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 11 ASP A 191
VAL A 242
PHE A 252
THR A 209
ILE A 212
 None
 1.10A 3n23A-1hl2A:
undetectable		 3n23A-1hl2A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		3 / 3 GLY A  45
ILE A  65
VAL A  66
 None
 0.50A 3nv6A-1hl2A:
0.4		 3nv6A-1hl2A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 6 GLY A  41
ASP A 203
ASP A 101
ASN A   4
 None
 0.98A 3vywC-1hl2A:
undetectable		 3vywC-1hl2A:
22.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		9 / 10 ILE A 139
THR A 167
GLY A 189
TYR A 190
ASP A 191
GLU A 192
GLY A 207
SER A 208
PHE A 252
 3PY  A 802 ( 4.9A)
3PY  A 802 (-3.6A)
None
None
None
None
None
None
None
 0.39A 4bwlC-1hl2A:
52.2		 4bwlC-1hl2A:
97.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 6 GLY A  38
ILE A  39
GLN A  37
TRP A 215
 None
 1.00A 4d39B-1hl2A:
0.0		 4d39B-1hl2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 6 GLY A  38
ILE A  39
GLN A  37
TRP A 215
 None
 1.00A 4kcnA-1hl2A:
0.0		 4kcnA-1hl2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 4 ALA A  10
VAL A  44
GLY A  49
THR A  48
 None
None
None
3PY  A 802 (-3.4A)
 0.96A 4ubeA-1hl2A:
2.9		 4ubeA-1hl2A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 7 ILE A 206
GLY A 205
PHE A  33
ASP A  40
 3PY  A 802 ( 4.9A)
None
None
None
 0.73A 5hieA-1hl2A:
undetectable		 5hieA-1hl2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 7 ILE A 206
GLY A 205
PHE A  33
ASP A  40
 3PY  A 802 ( 4.9A)
None
None
None
 0.73A 5hieB-1hl2A:
undetectable		 5hieB-1hl2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 8 ILE A 206
GLY A 205
PHE A  33
ASP A  40
 3PY  A 802 ( 4.9A)
None
None
None
 0.75A 5hieD-1hl2A:
undetectable		 5hieD-1hl2A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 5 LEU A 285
LYS A 286
ALA A 289
LEU A 292
 None
 0.86A 5vkqA-1hl2A:
0.0
5vkqD-1hl2A:
0.0		 5vkqA-1hl2A:
10.72
5vkqD-1hl2A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 5 LEU A 285
LYS A 286
ALA A 289
LEU A 292
 None
 0.85A 5vkqA-1hl2A:
0.0
5vkqB-1hl2A:
0.0		 5vkqA-1hl2A:
10.72
5vkqB-1hl2A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 5 LEU A 285
LYS A 286
ALA A 289
LEU A 292
 None
 0.84A 5vkqB-1hl2A:
0.0
5vkqC-1hl2A:
0.0		 5vkqB-1hl2A:
10.72
5vkqC-1hl2A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 5 LEU A 285
LYS A 286
ALA A 289
LEU A 292
 None
 0.85A 5vkqC-1hl2A:
0.0
5vkqD-1hl2A:
0.0		 5vkqC-1hl2A:
10.72
5vkqD-1hl2A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		5 / 9 VAL A  31
VAL A  62
GLY A  49
LEU A  13
VAL A  44
 None
 1.22A 6czmA-1hl2A:
0.0
6czmB-1hl2A:
0.0		 6czmA-1hl2A:
23.37
6czmB-1hl2A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1hl2 N-ACETYLNEURAMINATE
LYASE SUBUNIT
(Escherichia
coli) 		4 / 6 LEU A 269
CYH A 270
GLY A 275
ARG A 253
 None
 1.15A 6gtqB-1hl2A:
0.3
6gtqD-1hl2A:
undetectable		 6gtqB-1hl2A:
23.83
6gtqD-1hl2A:
10.14