SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hlb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_C_TFPC208_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1hlb HEMOGLOBIN (DEOXY)
(Molpadia
arenicola) 		4 / 5 PHE A 145
LEU A 125
MET A  81
SER A  82
 None
None
HEM  A 158 ( 4.8A)
None
 1.14A 1wrlC-1hlbA:
undetectable		 1wrlC-1hlbA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 1hlb HEMOGLOBIN (DEOXY)
(Molpadia
arenicola) 		5 / 12 LEU A  97
LEU A  96
VAL A  77
MET A  81
THR A 103
 None
None
HEM  A 158 ( 4.1A)
HEM  A 158 ( 4.8A)
HEM  A 158 (-3.2A)
 1.04A 2q7iA-1hlbA:
undetectable		 2q7iA-1hlbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 1hlb HEMOGLOBIN (DEOXY)
(Molpadia
arenicola) 		5 / 12 LEU A  97
LEU A  96
VAL A  77
MET A  81
THR A 103
 None
None
HEM  A 158 ( 4.1A)
HEM  A 158 ( 4.8A)
HEM  A 158 (-3.2A)
 1.04A 2q7kA-1hlbA:
undetectable		 2q7kA-1hlbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 1hlb HEMOGLOBIN (DEOXY)
(Molpadia
arenicola) 		5 / 12 LEU A  97
LEU A  96
VAL A  77
MET A  81
THR A 103
 None
None
HEM  A 158 ( 4.1A)
HEM  A 158 ( 4.8A)
HEM  A 158 (-3.2A)
 1.03A 2q7lA-1hlbA:
undetectable		 2q7lA-1hlbA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 1hlb HEMOGLOBIN (DEOXY)
(Molpadia
arenicola) 		5 / 12 LEU A  97
LEU A  96
VAL A  77
MET A  81
THR A 103
 None
None
HEM  A 158 ( 4.1A)
HEM  A 158 ( 4.8A)
HEM  A 158 (-3.2A)
 1.01A 3zqtA-1hlbA:
undetectable		 3zqtA-1hlbA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1hlb HEMOGLOBIN (DEOXY)
(Molpadia
arenicola) 		3 / 3 MET A  70
GLN A  69
ARG A  68
 None
 1.05A 5ewzB-1hlbA:
undetectable		 5ewzB-1hlbA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1hlb HEMOGLOBIN (DEOXY)
(Molpadia
arenicola) 		3 / 3 MET A  70
GLN A  69
ARG A  68
 None
 1.08A 5m35B-1hlbA:
undetectable		 5m35B-1hlbA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1hlb HEMOGLOBIN (DEOXY)
(Molpadia
arenicola) 		3 / 3 MET A  70
GLN A  69
ARG A  68
 None
 1.11A 5m36A-1hlbA:
undetectable		 5m36A-1hlbA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1hlb HEMOGLOBIN (DEOXY)
(Molpadia
arenicola) 		3 / 3 MET A  70
GLN A  69
ARG A  68
 None
 1.13A 6fnaB-1hlbA:
undetectable		 6fnaB-1hlbA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 1hlb HEMOGLOBIN (DEOXY)
(Molpadia
arenicola) 		3 / 3 MET A  70
GLN A  69
ARG A  68
 None
 1.13A 6fnbA-1hlbA:
undetectable		 6fnbA-1hlbA:
22.82