SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus;
Equus
caballus) 		5 / 12 LEU A 288
PHE B 370
PHE B 372
LEU A 293
TYR A 244
 None
 1.09A 1drfA-1hleA:
undetectable		 1drfA-1hleA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		3 / 3 MET A  23
LEU A  26
SER A  27
 ACE  A  22 ( 4.2A)
None
None
 0.54A 1ee2A-1hleA:
undetectable		 1ee2A-1hleA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		3 / 3 SER A 336
GLU A 294
GLU A 295
 None
 0.60A 1eqbD-1hleA:
undetectable		 1eqbD-1hleA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		3 / 3 SER A 336
GLU A 294
GLU A 295
 None
 0.60A 1eqbB-1hleA:
undetectable		 1eqbB-1hleA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		5 / 12 GLY B 386
THR A 276
ILE A 251
PHE B 373
LEU B 385
 None
 1.25A 1m2zD-1hleB:
undetectable		 1m2zD-1hleB:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		5 / 11 ILE A 332
THR A 351
LEU A 299
VAL A 308
PHE A  33
 None
 1.41A 1tw4A-1hleA:
0.3		 1tw4A-1hleA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		6 / 12 PHE B 384
ILE A 169
ALA A 349
ALA A 347
LEU A 248
TYR A 244
 None
 1.38A 2fr3A-1hleB:
undetectable		 2fr3A-1hleB:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus;
Equus
caballus) 		5 / 12 ILE A  50
ILE A 263
LEU A 260
VAL A 239
LEU B 385
 None
 1.09A 2qo5A-1hleA:
0.0		 2qo5A-1hleA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		5 / 11 SER A  53
LEU A 112
ILE A 188
PHE A 190
ALA A 347
 None
 1.36A 2v0mD-1hleA:
0.0		 2v0mD-1hleA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		4 / 8 TYR A 222
LYS A 224
LYS A 225
PRO A 228
 None
 1.29A 3bjwD-1hleA:
undetectable		 3bjwD-1hleA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus;
Equus
caballus) 		5 / 12 LEU A 260
GLY A  48
LEU A 299
ILE B 371
ILE A  57
 None
 0.82A 3frqB-1hleA:
undetectable		 3frqB-1hleA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		3 / 3 ASN A  42
ASP A  45
ARG A 209
 None
 0.82A 3k13C-1hleA:
0.0		 3k13C-1hleA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		5 / 9 GLY A 307
ILE A 332
PHE A  96
PHE A  33
PHE A  82
 None
 1.41A 3ko0A-1hleA:
undetectable
3ko0C-1hleA:
undetectable		 3ko0A-1hleA:
13.98
3ko0C-1hleA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		5 / 12 PHE A  82
LEU A 303
ILE A  57
LEU A  37
ASP A  36
 None
 1.28A 3ko0G-1hleA:
0.0
3ko0H-1hleA:
undetectable
3ko0I-1hleA:
0.0
3ko0J-1hleA:
0.0		 3ko0G-1hleA:
13.98
3ko0H-1hleA:
13.98
3ko0I-1hleA:
13.98
3ko0J-1hleA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		5 / 10 GLY A 307
ILE A 332
PHE A  96
PHE A  33
PHE A  82
 None
 1.37A 3ko0R-1hleA:
0.0
3ko0T-1hleA:
undetectable		 3ko0R-1hleA:
13.98
3ko0T-1hleA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		4 / 5 LEU A 112
TYR A 244
ILE B 374
ALA A 347
 None
 0.93A 3n8yB-1hleA:
0.0		 3n8yB-1hleA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		4 / 8 ARG A 154
ASN A 158
GLU A 156
ILE A 157
 None
 1.10A 4d33A-1hleA:
0.0		 4d33A-1hleA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		4 / 7 ARG A 154
ASN A 158
GLU A 156
ILE A 157
 None
 1.13A 4d33B-1hleA:
0.0		 4d33B-1hleA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		4 / 8 ARG A 154
ASN A 158
GLU A 156
ILE A 157
 None
 1.11A 4d39A-1hleA:
0.0		 4d39A-1hleA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		4 / 6 LYS A 181
GLY A 120
TYR A 119
ALA A 143
 None
 0.91A 4yshB-1hleA:
0.0		 4yshB-1hleA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus;
Equus
caballus) 		5 / 12 PRO B 369
GLY B 386
ILE A 252
ASN A  42
PHE B 388
 None
 1.13A 5fa8A-1hleB:
undetectable		 5fa8A-1hleB:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		3 / 3 ILE A 333
ILE A 169
MET A 177
 None
 0.60A 5i9yA-1hleA:
undetectable		 5i9yA-1hleA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		5 / 9 ILE A  57
VAL A 161
LEU A 172
ILE A 169
LEU A 303
 None
 1.44A 5iepA-1hleA:
0.0		 5iepA-1hleA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus) 		5 / 12 PHE B 370
ILE A 252
PHE A 291
PHE A  51
PHE B 384
 None
 1.28A 5v5zA-1hleB:
undetectable		 5v5zA-1hleB:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR
HORSE LEUKOCYTE
ELASTASE INHIBITOR
(Equus
caballus;
Equus
caballus) 		4 / 8 HIS A 287
ASN B 365
ASN A 285
ARG A 238
 None
 1.16A 6b94A-1hleA:
undetectable		 6b94A-1hleA:
13.03