SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hlg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 7 LEU A 354
THR A  72
ASN A  77
TYR A 259
 None
 1.28A 1afsA-1hlgA:
0.0		 1afsA-1hlgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 7 LEU A 354
THR A  72
ASN A  77
TYR A 259
 None
 1.28A 1afsB-1hlgA:
0.0		 1afsB-1hlgA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		6 / 12 ALA A 327
ASP A 328
LEU A 326
LEU A 179
ILE A 316
LEU A 335
 None
 1.47A 1errA-1hlgA:
undetectable		 1errA-1hlgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		5 / 11 PHE A 356
GLU A 365
VAL A 366
ILE A 370
ILE A 316
 None
 1.25A 2dg4A-1hlgA:
undetectable		 2dg4A-1hlgA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		3 / 3 LEU A 335
LEU A 326
PHE A 160
 None
 0.71A 2pgrA-1hlgA:
undetectable		 2pgrA-1hlgA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		3 / 3 ARG A 172
THR A 142
VAL A 139
 None
 0.96A 2q64A-1hlgA:
undetectable		 2q64A-1hlgA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 5 LEU A 131
GLY A  97
ILE A 138
ILE A 135
 None
 0.68A 2q9rA-1hlgA:
0.0		 2q9rA-1hlgA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 5 GLU A 347
PRO A 349
ILE A 348
GLY A 321
 None
 1.07A 2qeuA-1hlgA:
0.0
2qeuC-1hlgA:
0.0		 2qeuA-1hlgA:
17.30
2qeuC-1hlgA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		5 / 12 PHE A  62
TYR A 149
THR A  34
ALA A 133
ILE A 158
 None
 1.31A 2qm9B-1hlgA:
undetectable		 2qm9B-1hlgA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		5 / 12 VAL A 366
ILE A 370
PHE A 176
PHE A 160
ALA A 327
 None
 1.20A 3apwA-1hlgA:
undetectable		 3apwA-1hlgA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		5 / 12 VAL A 366
ILE A 370
PHE A 176
PHE A 160
ALA A 327
 None
 1.19A 3apwB-1hlgA:
0.0		 3apwB-1hlgA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		6 / 12 HIS A 353
ASP A 324
VAL A 150
GLY A  66
SER A 153
ALA A 178
 None
 1.45A 3keeB-1hlgA:
undetectable		 3keeB-1hlgA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		5 / 12 LEU A 169
ILE A 135
LEU A 131
ASP A 130
ASP A  36
 None
 1.17A 3ko0K-1hlgA:
undetectable
3ko0L-1hlgA:
undetectable
3ko0S-1hlgA:
undetectable
3ko0T-1hlgA:
undetectable		 3ko0K-1hlgA:
12.84
3ko0L-1hlgA:
12.84
3ko0S-1hlgA:
12.84
3ko0T-1hlgA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 7 GLU A 230
VAL A 226
LEU A 222
LEU A 325
 None
 0.87A 3qeoB-1hlgA:
2.2		 3qeoB-1hlgA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		3 / 3 PHE A 273
LYS A 280
SER A 281
 None
 0.89A 3tyeB-1hlgA:
undetectable		 3tyeB-1hlgA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		3 / 3 SER A 281
ASP A 331
ASP A 324
 None
 0.69A 3uj7A-1hlgA:
undetectable		 3uj7A-1hlgA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 5 GLY A  97
TRP A  74
ALA A  71
PHE A  85
 None
 1.45A 3wqwA-1hlgA:
2.1		 3wqwA-1hlgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 8 SER A  99
ILE A 173
VAL A 314
PHE A 176
 None
 0.99A 4dx7B-1hlgA:
0.1		 4dx7B-1hlgA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 8 THR A 188
LEU A 326
VAL A 182
VAL A 185
 None
 1.01A 4em2A-1hlgA:
0.0		 4em2A-1hlgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 6 TRP A 275
ILE A 161
SER A 164
ASP A 331
 None
 1.10A 4iaqA-1hlgA:
undetectable		 4iaqA-1hlgA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		3 / 3 HIS A  65
TRP A 358
SER A  99
 None
 0.90A 4lrhD-1hlgA:
0.0		 4lrhD-1hlgA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 8 VAL A  94
LEU A  63
ILE A 357
VAL A 366
 None
 0.96A 4ma7A-1hlgA:
undetectable		 4ma7A-1hlgA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		3 / 3 SER A 281
ASP A 331
ASP A 324
 None
 0.68A 4mwzA-1hlgA:
2.2		 4mwzA-1hlgA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		3 / 3 LYS A 249
ASN A  77
ASP A 247
 None
 0.80A 4o1eA-1hlgA:
undetectable		 4o1eA-1hlgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 6 VAL A 318
HIS A 345
LEU A 342
LEU A 335
 None
 1.12A 5hrqB-1hlgA:
undetectable
5hrqI-1hlgA:
undetectable
5hrqJ-1hlgA:
undetectable		 5hrqB-1hlgA:
4.85
5hrqI-1hlgA:
4.21
5hrqJ-1hlgA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 6 LEU A 169
SER A 168
ILE A 173
PHE A 163
 None
 0.94A 5jw1A-1hlgA:
0.0		 5jw1A-1hlgA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		3 / 3 PHE A 241
ASP A 247
LEU A 222
 None
 0.59A 5uhbC-1hlgA:
0.0		 5uhbC-1hlgA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		3 / 3 PHE A 241
ASP A 247
LEU A 222
 None
 0.60A 5uhcC-1hlgA:
0.0		 5uhcC-1hlgA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGG_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		5 / 12 PRO A 264
THR A 267
THR A 276
VAL A 279
VAL A 185
 None
 1.46A 5wggA-1hlgA:
0.0		 5wggA-1hlgA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		5 / 12 GLY A 155
VAL A 318
ILE A  75
GLY A  97
ALA A  84
 None
 0.95A 6c2mD-1hlgA:
0.0		 6c2mD-1hlgA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		5 / 10 ALA A 133
GLY A  37
ARG A 107
SER A 112
PHE A 118
 None
 1.13A 6clxB-1hlgA:
undetectable		 6clxB-1hlgA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		3 / 3 LEU A 240
ASN A 250
LEU A 256
 None
 0.61A 6exiA-1hlgA:
5.3		 6exiA-1hlgA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		4 / 6 TRP A 319
GLY A  66
ALA A 180
LEU A 179
 None
 0.93A 6fosA-1hlgA:
undetectable		 6fosA-1hlgA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1hlg LIPASE, GASTRIC
(Homo
sapiens) 		5 / 10 TYR A  30
VAL A  42
SER A  70
ALA A  69
ASN A  27
 None
 1.43A 6hu9L-1hlgA:
undetectable
6hu9P-1hlgA:
0.0
6hu9T-1hlgA:
0.0		 6hu9L-1hlgA:
24.26
6hu9P-1hlgA:
19.89
6hu9T-1hlgA:
11.75