SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hlk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		4 / 8 LEU A  80
THR A  85
LEU A  88
ALA A  65
 None
 0.83A 1fiqC-1hlkA:
2.4		 1fiqC-1hlkA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		5 / 12 ILE A  72
LEU A  80
HIS A  99
HIS A 223
TYR A  40
 None
None
ZN  A1001 (-3.4A)
113  A2002 ( 3.6A)
None
 1.23A 1fmlB-1hlkA:
undetectable		 1fmlB-1hlkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		5 / 11 LEU A  68
GLY A 179
GLY A 180
ILE A 167
TYR A 156
 None
 1.07A 1p91A-1hlkA:
undetectable		 1p91A-1hlkA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		4 / 8 LEU A  67
GLY A 102
ILE A  72
LEU A 111
 None
 0.74A 2o4nB-1hlkA:
undetectable		 2o4nB-1hlkA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		4 / 7 LEU A  88
ILE A  58
ALA A  44
ILE A  72
 None
 0.80A 2xkwA-1hlkA:
undetectable		 2xkwA-1hlkA:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		6 / 9 HIS A 101
ASP A 103
HIS A 162
CYH A 181
ASN A 193
HIS A 223
 ZN  A1001 (-3.3A)
ZN  A1002 ( 3.3A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 2.1A)
113  A2002 (-4.1A)
113  A2002 ( 3.6A)
 0.37A 4c1dA-1hlkA:
32.5		 4c1dA-1hlkA:
32.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		7 / 10 HIS A  99
HIS A 101
ASP A 103
HIS A 162
CYH A 181
ASN A 193
HIS A 223
 ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 3.3A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 2.1A)
113  A2002 (-4.1A)
113  A2002 ( 3.6A)
 0.40A 4c1dB-1hlkA:
32.6		 4c1dB-1hlkA:
32.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		7 / 11 TRP A  49
HIS A  99
HIS A 101
ASP A 103
HIS A 162
CYH A 181
HIS A 223
 113  A2002 (-3.9A)
ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 3.3A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 2.1A)
113  A2002 ( 3.6A)
 0.56A 4c1fA-1hlkA:
15.2
4c1fB-1hlkA:
32.3		 4c1fA-1hlkA:
35.65
4c1fB-1hlkA:
35.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		7 / 9 HIS A  99
HIS A 101
ASP A 103
HIS A 162
CYH A 181
GLY A 192
HIS A 223
 ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 3.3A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 2.1A)
113  A2002 ( 3.8A)
113  A2002 ( 3.6A)
 0.50A 4c1hA-1hlkA:
35.2		 4c1hA-1hlkA:
34.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		6 / 9 VAL A  52
HIS A 101
ASP A 103
HIS A 162
CYH A 181
HIS A 223
 113  A2002 ( 4.9A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 3.3A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 2.1A)
113  A2002 ( 3.6A)
 0.42A 4exsA-1hlkA:
31.8		 4exsA-1hlkA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		7 / 8 VAL A  52
HIS A 101
ASP A 103
HIS A 162
CYH A 181
ASN A 193
HIS A 223
 113  A2002 ( 4.9A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 3.3A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 2.1A)
113  A2002 (-4.1A)
113  A2002 ( 3.6A)
 0.55A 4exsB-1hlkA:
32.2		 4exsB-1hlkA:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		5 / 12 GLY A 159
GLY A 160
LEU A 144
GLY A 139
ASP A 165
 None
 0.97A 4fp9A-1hlkA:
undetectable		 4fp9A-1hlkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		5 / 12 GLY A 159
GLY A 160
LEU A 144
GLY A 139
ASP A 165
 None
 0.96A 4fp9C-1hlkA:
undetectable		 4fp9C-1hlkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		5 / 12 GLY A 159
GLY A 160
LEU A 144
GLY A 139
ASP A 165
 None
 0.95A 4fp9F-1hlkA:
undetectable		 4fp9F-1hlkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		4 / 8 SER A  42
SER A  54
HIS A 223
ILE A  46
 NA  A2001 ( 4.6A)
NA  A2001 ( 4.9A)
113  A2002 ( 3.6A)
113  A2002 (-4.1A)
 1.35A 4ms4A-1hlkA:
undetectable		 4ms4A-1hlkA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		5 / 11 ILE A  58
ALA A  66
ILE A 176
ARG A 217
LEU A  33
 None
 1.29A 4qi9C-1hlkA:
undetectable		 4qi9C-1hlkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		7 / 8 VAL A  52
HIS A 101
ASP A 103
HIS A 162
CYH A 181
ASN A 193
HIS A 223
 113  A2002 ( 4.9A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 3.3A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 2.1A)
113  A2002 (-4.1A)
113  A2002 ( 3.6A)
 0.40A 5a5zA-1hlkA:
32.5		 5a5zA-1hlkA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		5 / 7 HIS A 162
CYH A 181
GLY A 192
ASN A 193
HIS A 223
 ZN  A1001 (-3.3A)
ZN  A1002 ( 2.1A)
113  A2002 ( 3.8A)
113  A2002 (-4.1A)
113  A2002 ( 3.6A)
 0.50A 5a5zC-1hlkA:
32.2		 5a5zC-1hlkA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		4 / 7 HIS A 162
LYS A 184
GLY A 192
ASN A 193
 ZN  A1001 (-3.3A)
113  A2002 (-3.6A)
113  A2002 ( 3.8A)
113  A2002 (-4.1A)
 0.82A 5a5zC-1hlkA:
32.2		 5a5zC-1hlkA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		5 / 11 HIS A  99
HIS A 101
ASP A 103
HIS A 162
HIS A 223
 ZN  A1001 (-3.4A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 3.3A)
ZN  A1001 (-3.3A)
113  A2002 ( 3.6A)
 0.80A 5ayaA-1hlkA:
18.7		 5ayaA-1hlkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		4 / 7 TYR A 157
MET A 123
THR A 124
LEU A 127
 None
 0.89A 5xdqN-1hlkA:
undetectable
5xdqW-1hlkA:
0.0		 5xdqN-1hlkA:
18.15
5xdqW-1hlkA:
14.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		6 / 8 HIS A 101
ASP A 103
HIS A 162
CYH A 181
ASN A 193
HIS A 223
 ZN  A1001 (-3.3A)
ZN  A1002 ( 3.3A)
ZN  A1001 (-3.3A)
ZN  A1002 ( 2.1A)
113  A2002 (-4.1A)
113  A2002 ( 3.6A)
 0.51A 5zj8A-1hlkA:
14.4		 5zj8A-1hlkA:
30.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		4 / 5 ASN A  55
GLY A 192
HIS A 223
ASP A 103
 None
113  A2002 ( 3.8A)
113  A2002 ( 3.6A)
ZN  A1002 ( 3.3A)
 0.96A 6gh9A-1hlkA:
undetectable		 6gh9A-1hlkA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1hlk BETA-LACTAMASE, TYPE
II
(Bacteroides
fragilis) 		4 / 5 TYR A 157
MET A 123
THR A 124
LEU A 127
 None
 0.85A 6nknW-1hlkA:
0.0		 6nknW-1hlkA:
14.55