SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hm6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		4 / 8 SER A 244
VAL A   4
SER A   5
ASP A 247
 None
 1.24A 1hwkA-1hm6A:
undetectable		 1hwkA-1hm6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		4 / 8 SER A 244
VAL A   4
SER A   5
ASP A 247
 None
 1.25A 1hwkC-1hm6A:
undetectable		 1hwkC-1hm6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		4 / 8 SER A 244
VAL A   4
SER A   5
ASP A 247
 None
 1.25A 1hwkD-1hm6A:
0.0		 1hwkD-1hm6A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		3 / 3 GLU A  62
LYS A  58
VAL A  60
 None
 1.00A 1l2iA-1hm6A:
0.0		 1l2iA-1hm6A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		3 / 3 THR A 136
LEU A 137
LEU A 181
 None
 0.63A 1mz9C-1hm6A:
undetectable		 1mz9C-1hm6A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		3 / 3 ARG A 204
TYR A 243
LYS A 242
 None
 0.81A 1uujB-1hm6A:
0.0		 1uujB-1hm6A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		4 / 6 GLU A  49
ASP A  47
PHE A  42
ARG A  72
 None
 1.46A 2a3bB-1hm6A:
undetectable		 2a3bB-1hm6A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		4 / 5 ILE A 222
LEU A 218
ASP A 259
ALA A 179
 None
 0.96A 2opxA-1hm6A:
undetectable		 2opxA-1hm6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		5 / 9 LEU A 218
LEU A 225
ALA A 209
LEU A 206
PHE A   7
 None
 1.15A 2vcvI-1hm6A:
0.7		 2vcvI-1hm6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		5 / 10 TYR A 240
MET A   3
LEU A 233
VAL A 268
LEU A 225
 None
 1.33A 2w98A-1hm6A:
undetectable		 2w98A-1hm6A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		4 / 8 LEU A  51
ILE A  65
LEU A  69
LEU A  92
 None
 0.77A 2xfhA-1hm6A:
undetectable		 2xfhA-1hm6A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		5 / 12 LEU A 256
ILE A 260
THR A 265
VAL A 268
LEU A 225
 None
 1.21A 3a51D-1hm6A:
0.0		 3a51D-1hm6A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1hm6 ANNEXIN 1
(Sus
scrofa) 		5 / 9 ALA A 179
LEU A 264
VAL A 267
ILE A 224
LEU A 233
 None
 1.32A 3fl9H-1hm6A:
undetectable		 3fl9H-1hm6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		4 / 4 LYS A 185
GLN A 177
ILE A 260
LEU A 225
 None
 1.44A 3qt0A-1hm6A:
0.1		 3qt0A-1hm6A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		4 / 7 VAL A 301
MET A 300
LYS A 281
TYR A 315
 None
 1.17A 4lb2A-1hm6A:
2.0		 4lb2A-1hm6A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		3 / 3 VAL A 107
LEU A 111
VAL A 301
 None
 0.60A 4wq4A-1hm6A:
undetectable		 4wq4A-1hm6A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		3 / 3 GLY A 344
THR A  41
PRO A  38
 None
 0.46A 5v5zA-1hm6A:
0.0		 5v5zA-1hm6A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		3 / 3 TYR A 335
ALA A 341
LEU A 342
 None
 0.52A 6ag0C-1hm6A:
undetectable		 6ag0C-1hm6A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1hm6 ANNEXIN 1
(Sus
scrofa) 		5 / 12 TYR A 240
ALA A 205
ALA A 209
THR A 216
LEU A 254
 None
 1.33A 6aycA-1hm6A:
undetectable		 6aycA-1hm6A:
13.29