SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hm7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		5 / 11 ARG A  21
LEU A  66
HIS A  60
ALA A  61
GLY A 190
 None
 1.34A 1cmaA-1hm7A:
undetectable
1cmaB-1hm7A:
undetectable		 1cmaA-1hm7A:
16.54
1cmaB-1hm7A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 4 HIS A 118
ALA A 117
PHE A 120
GLY A 119
 None
 1.37A 1mjoB-1hm7A:
undetectable		 1mjoB-1hm7A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 6 PRO A 181
LEU A 216
ILE A 177
SER A 305
 None
 1.23A 1sbrA-1hm7A:
undetectable
1sbrB-1hm7A:
0.5		 1sbrA-1hm7A:
19.88
1sbrB-1hm7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 7 PHE A 199
ARG A 138
HIS A 142
VAL A 179
 None
 1.34A 1wu8A-1hm7A:
undetectable
1wu8C-1hm7A:
undetectable		 1wu8A-1hm7A:
22.57
1wu8C-1hm7A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 7 ARG A 294
VAL A 298
ARG A 299
ILE A 302
 None
 0.89A 2yfbA-1hm7A:
2.8		 2yfbA-1hm7A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 6 ARG A 294
VAL A 298
ARG A 299
ILE A 302
 None
 1.00A 2yfbB-1hm7A:
undetectable		 2yfbB-1hm7A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 7 VAL A  70
SER A  74
HIS A  45
LEU A  27
 None
 0.90A 3arrA-1hm7A:
1.0		 3arrA-1hm7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		3 / 3 GLU A 193
HIS A 196
THR A 132
 None
 0.77A 3hkuA-1hm7A:
undetectable		 3hkuA-1hm7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 7 PHE A 192
ARG A 299
LEU A 208
ARG A 292
 None
 1.14A 3nxuA-1hm7A:
0.0		 3nxuA-1hm7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 7 HIS A   8
GLU A 258
ARG A 260
GLU A 264
 None
 1.40A 3ql6A-1hm7A:
0.0		 3ql6A-1hm7A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 4 ASP A  81
ASP A  80
GLY A  85
THR A  94
 None
 1.37A 3tl9B-1hm7A:
undetectable		 3tl9B-1hm7A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 8 HIS A 309
ASP A 220
LEU A 219
ILE A 177
 None
 1.05A 4k0bA-1hm7A:
0.0		 4k0bA-1hm7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 7 THR A 182
ALA A 186
ALA A  61
THR A 300
 None
 1.03A 4qw0K-1hm7A:
undetectable		 4qw0K-1hm7A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		4 / 7 THR A 182
ALA A 186
ALA A  61
THR A 300
 None
 1.03A 4qw0Y-1hm7A:
undetectable		 4qw0Y-1hm7A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 1hm7 PENTALENENE SYNTHASE
(Streptomyces
exfoliatus) 		5 / 12 LEU A 219
PHE A  57
LEU A  53
TYR A  50
GLY A 304
 None
 1.31A 4zbrA-1hm7A:
undetectable		 4zbrA-1hm7A:
21.02