SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		3 / 3 GLU A  49
THR A  48
LEU A  81
 ZN  A 125 ( 2.1A)
None
None
 0.70A 1v8bC-1hmlA:
undetectable		 1v8bC-1hmlA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		4 / 6 GLY A 100
ILE A  95
ILE A  98
ASP A 102
 None
 0.98A 3a7eA-1hmlA:
undetectable		 3a7eA-1hmlA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		5 / 12 LEU A  52
ILE A  41
ASP A  88
ILE A  89
ASP A  37
 None
None
CA  A 124 ( 3.2A)
None
None
 1.07A 3axtA-1hmlA:
undetectable		 3axtA-1hmlA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		4 / 6 ASN A  44
GLU A  49
LYS A  58
ASN A  57
 None
ZN  A 125 ( 2.1A)
None
None
 1.43A 3kp6A-1hmlA:
undetectable
3kp6B-1hmlA:
0.4		 3kp6A-1hmlA:
25.86
3kp6B-1hmlA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		4 / 6 TYR A  50
ILE A  41
SER A  64
SER A  63
 None
 1.30A 3pmzD-1hmlA:
undetectable		 3pmzD-1hmlA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		5 / 12 ILE A  89
ALA A  92
LEU A  52
LEU A   8
ILE A  27
 None
 0.99A 3uvvA-1hmlA:
0.0		 3uvvA-1hmlA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4II8_A_010A210_0
(LYSOZYME C)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		4 / 7 GLN A  54
TRP A  60
ILE A  95
TRP A 104
 None
 0.41A 4ii8A-1hmlA:
19.8		 4ii8A-1hmlA:
37.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		4 / 5 THR A  33
GLU A  49
THR A  48
LEU A  81
 None
ZN  A 125 ( 2.1A)
None
None
 1.26A 5hm8B-1hmlA:
undetectable		 5hm8B-1hmlA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		4 / 5 THR A  33
GLU A  49
THR A  48
LEU A  81
 None
ZN  A 125 ( 2.1A)
None
None
 1.26A 5hm8E-1hmlA:
undetectable		 5hm8E-1hmlA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		4 / 5 THR A  33
GLU A  49
THR A  48
LEU A  81
 None
ZN  A 125 ( 2.1A)
None
None
 1.23A 5utuH-1hmlA:
undetectable		 5utuH-1hmlA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1hml ALPHA-LACTALBUMIN
(Homo
sapiens) 		4 / 5 LEU A  52
LYS A   1
LEU A   8
GLU A   7
 None
 1.21A 5weaA-1hmlA:
undetectable		 5weaA-1hmlA:
10.56