SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hnf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1hnf CD2
(Homo
sapiens) 		3 / 3 ARG A 105
GLU A 104
GLN A  15
 None
NAG  A 502 (-3.9A)
None
 0.96A 2p16A-1hnfA:
1.0		 2p16A-1hnfA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1hnf CD2
(Homo
sapiens) 		4 / 7 PHE A  98
TYR A  81
VAL A  83
ILE A  33
 None
NA  A 629 (-4.7A)
None
None
 0.79A 4a97E-1hnfA:
0.0		 4a97E-1hnfA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1hnf CD2
(Homo
sapiens) 		4 / 8 PHE A  98
TYR A  81
VAL A  83
ILE A  33
 None
NA  A 629 (-4.7A)
None
None
 0.86A 4a97I-1hnfA:
undetectable		 4a97I-1hnfA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 1hnf CD2
(Homo
sapiens) 		3 / 3 ARG A  48
LYS A  49
LYS A  51
 None
 0.97A 4k50A-1hnfA:
0.0		 4k50A-1hnfA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 1hnf CD2
(Homo
sapiens) 		3 / 3 ARG A  48
LYS A  49
LYS A  51
 None
 0.84A 4k50E-1hnfA:
0.0		 4k50E-1hnfA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 1hnf CD2
(Homo
sapiens) 		3 / 3 ARG A  48
LYS A  49
LYS A  51
 None
 0.90A 4k50I-1hnfA:
0.0		 4k50I-1hnfA:
18.75