SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  32
PHE A  72
ASN A 152
LEU A 153
TYR A  38
 None
 1.19A 1dhfA-1hnoA:
undetectable		 1dhfA-1hnoA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 246
ILE A 241
THR A 105
 None
 0.79A 1rx3A-1hnoA:
undetectable		 1rx3A-1hnoA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  32
PHE A  72
ASN A 152
LEU A 153
TYR A  38
 None
 1.15A 2w3mB-1hnoA:
undetectable		 2w3mB-1hnoA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		3 / 3 THR A  57
SER A 112
LYS A 237
 None
 0.89A 3aocC-1hnoA:
0.0		 3aocC-1hnoA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 168
ILE A  58
PHE A  20
 EDO  A 281 (-2.8A)
None
None
 0.96A 3j7zS-1hnoA:
undetectable
3j7za-1hnoA:
undetectable		 3j7zS-1hnoA:
15.96
3j7za-1hnoA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A  38
ALA A 129
GLY A 160
LEU A 165
ALA A 123
 None
 1.29A 3ou7C-1hnoA:
undetectable		 3ou7C-1hnoA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 246
ILE A 241
THR A 105
 None
 0.81A 4gh8A-1hnoA:
undetectable		 4gh8A-1hnoA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  59
TYR A 148
PHE A 184
LEU A 178
LEU A 133
 None
None
None
None
EDO  A 281 (-4.2A)
 1.18A 4j03A-1hnoA:
undetectable		 4j03A-1hnoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		4 / 8 SER A  62
SER A  12
GLU A  36
ASP A  37
 None
 1.05A 4qb9D-1hnoA:
0.9		 4qb9D-1hnoA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 9 ASN A 248
ILE A 109
GLY A 159
THR A 157
VAL A 163
 None
 1.30A 4r20B-1hnoA:
0.0		 4r20B-1hnoA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 255
ALA A  70
ASN A 248
THR A 105
LEU A 130
 None
 1.36A 4z7fC-1hnoA:
undetectable		 4z7fC-1hnoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  24
PHE A 108
LEU A 130
GLY A  42
SER A  67
 None
 1.30A 4zbrA-1hnoA:
undetectable		 4zbrA-1hnoA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 203
GLY A 121
PRO A 122
VAL A 144
PHE A  65
 EDO  A 282 (-3.0A)
None
None
None
None
 1.29A 5jo9A-1hnoA:
undetectable		 5jo9A-1hnoA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 143
LEU A 146
ILE A 195
 EDO  A 282 (-2.8A)
None
None
 0.68A 5kc0A-1hnoA:
undetectable		 5kc0A-1hnoA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		6 / 12 GLY A 125
ASN A 101
VAL A 104
VAL A 131
ALA A 132
LEU A 130
 None
 1.33A 5kocA-1hnoA:
undetectable		 5kocA-1hnoA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 9 GLU A 158
VAL A 104
GLY A  69
SER A 127
LEU A  33
 None
 1.41A 5ksnA-1hnoA:
0.0		 5ksnA-1hnoA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSN_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 9 GLU A 158
VAL A 104
GLY A  69
SER A 127
LEU A  33
 None
 1.42A 5ksnB-1hnoA:
0.0		 5ksnB-1hnoA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 9 GLU A 158
VAL A 104
GLY A  69
SER A 127
LEU A  33
 None
 1.40A 5kt8B-1hnoA:
0.0		 5kt8B-1hnoA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXS_B_NIZB806_1
(CATALASE-PEROXIDASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 9 GLU A 158
VAL A 104
GLY A  69
SER A 127
LEU A  33
 None
 1.40A 5sxsB-1hnoA:
0.0		 5sxsB-1hnoA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 9 GLU A 158
VAL A 104
GLY A  69
SER A 127
LEU A  33
 None
 1.42A 5syiB-1hnoA:
0.0		 5syiB-1hnoA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 12 SER A  67
ILE A  59
TYR A  38
ALA A 123
LEU A 146
 None
 1.44A 5zwrB-1hnoA:
undetectable		 5zwrB-1hnoA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		4 / 6 CYH A 190
PHE A 169
TYR A 148
LEU A 119
 None
 1.49A 6a7pB-1hnoA:
0.0		 6a7pB-1hnoA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDQ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 9 GLU A 158
VAL A 104
GLY A  69
SER A 127
LEU A  33
 None
 1.42A 6cdqA-1hnoA:
0.5		 6cdqA-1hnoA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1hno D3,D2-ENOYL COA
ISOMERASE ECI1
(Saccharomyces
cerevisiae) 		5 / 9 GLU A 158
VAL A 104
GLY A  69
SER A 127
LEU A  33
 None
 1.43A 6cfqB-1hnoA:
0.0		 6cfqB-1hnoA:
13.67