SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hp1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		7 / 11 ARG A 379
SER A 405
GLY A 406
ASN A 431
GLY A 458
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
ATP  A 606 ( 4.2A)
None
ATP  A 606 (-3.1A)
ATP  A 606 (-3.6A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 1.20A 1ho5A-1hp1A:
56.5		 1ho5A-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		9 / 11 ARG A 379
SER A 405
GLY A 407
ARG A 410
PHE A 429
ASN A 431
GLY A 458
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.3A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.1A)
ATP  A 606 (-3.6A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 0.60A 1ho5A-1hp1A:
56.5		 1ho5A-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 11 ARG A 410
PHE A 429
ASN A 431
GLY A 406
PHE A 498
 ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.1A)
None
ATP  A 606 (-3.6A)
 1.48A 1ho5A-1hp1A:
56.5		 1ho5A-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 11 GLY A 408
ARG A 410
PHE A 429
GLY A 406
PHE A 498
 ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
None
ATP  A 606 (-3.6A)
 1.37A 1ho5A-1hp1A:
56.5		 1ho5A-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		6 / 11 SER A 405
GLY A 408
ARG A 410
PHE A 429
PHE A 498
ASP A 504
 ATP  A 606 ( 4.2A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 1.28A 1ho5A-1hp1A:
56.5		 1ho5A-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		7 / 10 ARG A 379
SER A 405
GLY A 406
ASN A 431
GLY A 458
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
ATP  A 606 ( 4.2A)
None
ATP  A 606 (-3.1A)
ATP  A 606 (-3.6A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 1.18A 1ho5B-1hp1A:
56.3		 1ho5B-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		9 / 10 ARG A 379
SER A 405
GLY A 407
ARG A 410
PHE A 429
ASN A 431
GLY A 458
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.3A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.1A)
ATP  A 606 (-3.6A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 0.60A 1ho5B-1hp1A:
56.3		 1ho5B-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 10 GLY A 408
ARG A 410
PHE A 429
GLY A 406
PHE A 498
 ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
None
ATP  A 606 (-3.6A)
 1.24A 1ho5B-1hp1A:
56.3		 1ho5B-1hp1A:
98.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1HO5_B_ADNB2604_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		6 / 10 SER A 405
GLY A 408
ARG A 410
PHE A 429
PHE A 498
ASP A 504
 ATP  A 606 ( 4.2A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 1.20A 1ho5B-1hp1A:
56.3		 1ho5B-1hp1A:
98.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 THR A 171
GLY A 115
GLY A 219
GLY A 250
 None
 0.69A 1jhqA-1hp1A:
undetectable		 1jhqA-1hp1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 THR A 171
GLY A 115
GLY A 219
GLY A 250
 None
 0.66A 1jhvA-1hp1A:
undetectable		 1jhvA-1hp1A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 THR A  35
ASP A 299
ASN A 311
LEU A  62
 None
 1.05A 1lhvA-1hp1A:
undetectable		 1lhvA-1hp1A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 5 LEU A 536
VAL A 538
TYR A 541
THR A 367
 None
 1.27A 1nw3A-1hp1A:
undetectable		 1nw3A-1hp1A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 ASP A  84
HIS A 117
HIS A  43
 ZN  A 601 (-2.7A)
CO3  A 602 (-3.8A)
ZN  A 600 (-3.3A)
 0.69A 1oe1A-1hp1A:
undetectable		 1oe1A-1hp1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 ASP A  84
HIS A 117
HIS A  43
 ZN  A 601 (-2.7A)
CO3  A 602 (-3.8A)
ZN  A 600 (-3.3A)
 0.68A 1oe3A-1hp1A:
undetectable		 1oe3A-1hp1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 ALA A 402
GLN A 393
ILE A 389
ILE A 409
 None
 0.91A 1p7lD-1hp1A:
0.0		 1p7lD-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 ALA A 402
GLN A 393
ILE A 389
ILE A 409
 None
 0.91A 1p7lC-1hp1A:
0.0		 1p7lC-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 ILE A 168
ILE A 212
THR A 216
 None
 0.54A 1rg7A-1hp1A:
undetectable		 1rg7A-1hp1A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 ALA A 402
GLN A 393
ILE A 389
ILE A 409
 None
 0.91A 1rg9B-1hp1A:
undetectable		 1rg9B-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 ALA A 402
GLN A 393
ILE A 389
ILE A 409
 None
 0.91A 1rg9A-1hp1A:
undetectable		 1rg9A-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 ALA A 402
GLN A 393
ILE A 389
ILE A 409
 None
 0.92A 1rg9D-1hp1A:
1.2		 1rg9D-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 ALA A 402
GLN A 393
ILE A 389
ILE A 409
 None
 0.92A 1rg9C-1hp1A:
0.0		 1rg9C-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 ILE A 248
GLY A 250
ASP A  84
HIS A 252
GLY A 115
 None
None
ZN  A 601 (-2.7A)
ZN  A 601 ( 3.4A)
None
 1.08A 1zz1C-1hp1A:
undetectable		 1zz1C-1hp1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 ASP A  84
HIS A 117
HIS A  43
 ZN  A 601 (-2.7A)
CO3  A 602 (-3.8A)
ZN  A 600 (-3.3A)
 0.70A 2xxgA-1hp1A:
undetectable		 2xxgA-1hp1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 ASP A  84
HIS A 117
HIS A  43
 ZN  A 601 (-2.7A)
CO3  A 602 (-3.8A)
ZN  A 600 (-3.3A)
 0.70A 2xxgC-1hp1A:
undetectable		 2xxgC-1hp1A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 MET A 104
GLU A 118
ASN A 116
 None
None
CO3  A 602 ( 2.6A)
 1.08A 3a27A-1hp1A:
undetectable		 3a27A-1hp1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 11 THR A 216
ILE A 213
LEU A 240
MET A 236
ILE A 283
 None
 1.27A 3a50C-1hp1A:
undetectable		 3a50C-1hp1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 THR A 216
ILE A 213
LEU A 240
MET A 236
ILE A 283
 None
 1.26A 3a50E-1hp1A:
undetectable		 3a50E-1hp1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 7 GLY A 440
ASP A 437
TYR A 491
ARG A 492
 None
 1.14A 3aruA-1hp1A:
undetectable		 3aruA-1hp1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 GLY A 115
HIS A  43
LEU A 138
SER A 139
SER A  81
 None
ZN  A 600 (-3.3A)
None
None
None
 1.09A 3bxoA-1hp1A:
undetectable		 3bxoA-1hp1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 GLY A 115
HIS A  43
LEU A 138
SER A 139
SER A  81
 None
ZN  A 600 (-3.3A)
None
None
None
 1.12A 3bxoB-1hp1A:
undetectable		 3bxoB-1hp1A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 GLU A 118
HIS A  42
HIS A  43
 None
None
ZN  A 600 (-3.3A)
 0.91A 3co4A-1hp1A:
2.4		 3co4A-1hp1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 4 GLU A 414
GLY A 416
THR A 367
GLU A 366
 None
 1.10A 3e9xA-1hp1A:
0.0		 3e9xA-1hp1A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 PHE A 119
GLY A 179
ASP A 173
ILE A 187
TYR A 435
 None
 1.12A 3eeoA-1hp1A:
2.1		 3eeoA-1hp1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 ILE A 200
ILE A 168
ALA A 196
ALA A 237
ILE A 285
 None
 1.05A 3gwsX-1hp1A:
0.0		 3gwsX-1hp1A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 6 GLU A 118
ASN A  86
SER A  81
PHE A 135
 None
 1.41A 3i9jB-1hp1A:
undetectable		 3i9jB-1hp1A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 10 THR A  39
TYR A 109
SER A  81
GLY A  82
GLY A  83
 None
 1.32A 3ixlA-1hp1A:
0.2		 3ixlA-1hp1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 ASP A 504
ASN A 499
SER A 457
 ATP  A 606 (-2.8A)
None
None
 0.89A 3lslA-1hp1A:
undetectable
3lslD-1hp1A:
undetectable		 3lslA-1hp1A:
22.22
3lslD-1hp1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 SER A 457
ASP A 504
ASN A 499
 None
ATP  A 606 (-2.8A)
None
 0.89A 3lslA-1hp1A:
undetectable
3lslD-1hp1A:
0.0		 3lslA-1hp1A:
22.22
3lslD-1hp1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 9 VAL A 443
ILE A 480
ALA A 399
VAL A 403
VAL A 466
 None
 1.10A 3me6C-1hp1A:
undetectable		 3me6C-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 9 VAL A 443
ILE A 480
ALA A 399
VAL A 403
VAL A 466
 None
 1.15A 3me6D-1hp1A:
undetectable		 3me6D-1hp1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 GLY A 115
HIS A  43
LEU A 138
SER A 139
SER A  81
 None
ZN  A 600 (-3.3A)
None
None
None
 1.23A 3pfgA-1hp1A:
undetectable		 3pfgA-1hp1A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 GLY A 115
PHE A 101
PHE A 184
ILE A 187
ILE A 142
 None
 1.11A 3pwwA-1hp1A:
undetectable		 3pwwA-1hp1A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 ALA A 298
MET A 247
LEU A  80
ARG A 160
ILE A  34
 None
 1.17A 3ql3A-1hp1A:
undetectable		 3ql3A-1hp1A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 GLY A 365
ASN A 422
ASP A 537
VAL A 538
GLY A 416
 None
 0.92A 3sglA-1hp1A:
undetectable		 3sglA-1hp1A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 ALA A 464
ASN A 465
ALA A 399
THR A 397
 None
 0.90A 3t3sD-1hp1A:
undetectable		 3t3sD-1hp1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 ALA A 464
ASN A 465
ALA A 399
THR A 397
 None
 0.96A 3t3sE-1hp1A:
0.0		 3t3sE-1hp1A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 7 ASP A 120
PHE A 119
GLY A 115
THR A  87
 None
 1.14A 3vnsA-1hp1A:
1.3		 3vnsA-1hp1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		6 / 9 GLY A 407
GLY A 408
PHE A 429
ASN A 431
GLY A 458
ASP A 504
 ATP  A 606 (-3.3A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.1A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 0.53A 3ztvA-1hp1A:
35.6		 3ztvA-1hp1A:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFB_B_KANB401_1
(APH(2')-ID)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 10 ASP A  84
ASP A 120
HIS A 117
ASP A  41
GLU A 130
 ZN  A 601 (-2.7A)
None
CO3  A 602 (-3.8A)
ZN  A 600 (-3.1A)
None
 1.48A 4dfbB-1hp1A:
0.0		 4dfbB-1hp1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 7 LEU A  56
ILE A  85
THR A  39
GLY A 292
 None
 0.97A 4eq4A-1hp1A:
0.7		 4eq4A-1hp1A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 9 ARG A 379
GLY A 406
GLY A 408
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
None
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 1.26A 4h2fA-1hp1A:
36.8		 4h2fA-1hp1A:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		8 / 9 ARG A 379
GLY A 407
GLY A 408
ARG A 410
PHE A 429
GLY A 458
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
ATP  A 606 (-3.3A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.6A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 0.50A 4h2fA-1hp1A:
36.8		 4h2fA-1hp1A:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 9 GLY A 408
ARG A 410
PHE A 429
GLY A 406
PHE A 498
 ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
None
ATP  A 606 (-3.6A)
 1.14A 4h2fA-1hp1A:
36.8		 4h2fA-1hp1A:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 9 GLY A 408
ARG A 410
PHE A 429
PHE A 498
ASP A 504
 ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 1.11A 4h2fA-1hp1A:
36.8		 4h2fA-1hp1A:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		8 / 9 ARG A 379
GLY A 407
GLY A 408
ARG A 410
PHE A 429
GLY A 458
PHE A 498
ASP A 504
 ATP  A 606 (-3.2A)
ATP  A 606 (-3.3A)
ATP  A 606 ( 4.2A)
ATP  A 606 (-3.4A)
ATP  A 606 (-3.8A)
ATP  A 606 (-3.6A)
ATP  A 606 (-3.6A)
ATP  A 606 (-2.8A)
 0.40A 4h2gA-1hp1A:
39.1		 4h2gA-1hp1A:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 ASP A  41
VAL A  89
ASN A 116
 ZN  A 600 (-3.1A)
None
CO3  A 602 ( 2.6A)
 0.69A 4lmnA-1hp1A:
undetectable		 4lmnA-1hp1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 5 VAL A 167
LEU A  78
ILE A 165
LEU A 157
 None
 0.87A 4mghA-1hp1A:
0.0		 4mghA-1hp1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 ALA A 402
GLN A 393
ILE A 389
ILE A 409
 None
 0.95A 4ndnD-1hp1A:
undetectable		 4ndnD-1hp1A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 11 ASP A 486
VAL A 443
ILE A 480
THR A 448
ILE A 444
 None
 0.98A 4njvC-1hp1A:
undetectable		 4njvC-1hp1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 6 MET A 218
MET A 236
LEU A 245
ILE A 165
 None
 1.14A 4okxA-1hp1A:
undetectable		 4okxA-1hp1A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 11 ALA A 298
MET A 247
LEU A  80
ARG A 160
ILE A  34
 None
 1.13A 4p66A-1hp1A:
undetectable		 4p66A-1hp1A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 LEU A 371
THR A 367
ILE A 418
GLY A 365
ILE A 364
 None
 1.08A 5ifuA-1hp1A:
undetectable		 5ifuA-1hp1A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 6 PRO A 455
GLU A 542
ALA A 464
LEU A 390
 None
 1.09A 5igiA-1hp1A:
0.0		 5igiA-1hp1A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		3 / 3 VAL A 310
GLU A  69
GLU A  73
 None
 0.64A 5jsdB-1hp1A:
0.0
5jsdC-1hp1A:
0.0		 5jsdB-1hp1A:
21.62
5jsdC-1hp1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 4 ASP A  84
HIS A 217
HIS A 252
HIS A 117
 ZN  A 601 (-2.7A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 3.4A)
CO3  A 602 (-3.8A)
 1.48A 5ncdD-1hp1A:
undetectable		 5ncdD-1hp1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 8 ALA A 402
GLN A 393
ILE A 389
ILE A 409
 None
 0.92A 5t8sA-1hp1A:
undetectable		 5t8sA-1hp1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 6 VAL A 167
PRO A 209
ALA A 215
THR A 216
 None
 0.99A 6cduB-1hp1A:
0.0
6cduC-1hp1A:
0.0		 6cduB-1hp1A:
22.20
6cduC-1hp1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 7 ILE A 165
VAL A 167
PRO A 209
ALA A 215
 None
 0.91A 6cduC-1hp1A:
0.0
6cduD-1hp1A:
undetectable		 6cduC-1hp1A:
22.20
6cduD-1hp1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 8 ILE A 165
VAL A 167
PRO A 209
ALA A 215
THR A 216
 None
 1.32A 6cduD-1hp1A:
undetectable
6cduE-1hp1A:
undetectable		 6cduD-1hp1A:
22.20
6cduE-1hp1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 8 ILE A 211
VAL A 167
PRO A 209
ALA A 215
THR A 216
 None
 1.28A 6cduD-1hp1A:
undetectable
6cduE-1hp1A:
undetectable		 6cduD-1hp1A:
22.20
6cduE-1hp1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		4 / 7 ALA A 215
ILE A 165
VAL A 167
PRO A 209
 None
 0.89A 6cduF-1hp1A:
undetectable
6cduJ-1hp1A:
0.0		 6cduF-1hp1A:
22.20
6cduJ-1hp1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 12 LEU A 478
PRO A 484
ILE A 444
ILE A 480
ASP A 486
 None
 0.92A 6emuA-1hp1A:
undetectable		 6emuA-1hp1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1hp1 5'-NUCLEOTIDASE
(Escherichia
coli) 		5 / 9 ASP A 255
GLY A  88
ASN A 517
VAL A 432
ILE A 521
 None
 1.43A 6giqA-1hp1A:
0.0
6giqE-1hp1A:
0.0
6giqI-1hp1A:
0.0		 6giqA-1hp1A:
23.55
6giqE-1hp1A:
17.18
6giqI-1hp1A:
8.98