SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hpg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 VAL A 231
SER A 207
VAL A 118
GLY A  18
ALA A 198
 None
 1.25A 2x2iA-1hpgA:
undetectable		 2x2iA-1hpgA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 ALA A 226
SER A 139
ALA A  44
GLY A 196
THR A  54
 None
 1.07A 2zifB-1hpgA:
undetectable		 2zifB-1hpgA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 11 LEU A 235
ALA A 128
ALA A 127
VAL A 239
HIS A 228
 None
 0.96A 3bszE-1hpgA:
0.0		 3bszE-1hpgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 11 THR A 117
GLN A 122
ALA A  44
GLY A  19
ALA A 198
 None
 1.18A 3mg0H-1hpgA:
undetectable
3mg0I-1hpgA:
undetectable		 3mg0H-1hpgA:
18.47
3mg0I-1hpgA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 VAL A  48
VAL A 231
LEU A 235
GLY A 197
ALA A  45
 None
 1.03A 3n8wA-1hpgA:
0.0		 3n8wA-1hpgA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 VAL A  48
VAL A 231
LEU A 235
GLY A 197
ALA A  45
 None
 1.05A 3n8zA-1hpgA:
0.0		 3n8zA-1hpgA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 10 THR A 183
HIS A 213
GLY A 197
GLY A 224
ALA A 190
 None
 1.19A 3pp7B-1hpgA:
undetectable		 3pp7B-1hpgA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 VAL A  48
VAL A 231
LEU A 235
GLY A 197
ALA A  45
 None
 1.08A 3rr3A-1hpgA:
0.0		 3rr3A-1hpgA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 VAL A  48
VAL A 231
LEU A 235
GLY A 197
ALA A  45
 None
 1.08A 3rr3B-1hpgA:
0.0		 3rr3B-1hpgA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 VAL A  48
VAL A 231
LEU A 235
GLY A 197
ALA A  45
 None
 1.08A 3rr3C-1hpgA:
0.0		 3rr3C-1hpgA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 VAL A  48
VAL A 231
LEU A 235
GLY A 197
ALA A  45
 None
 1.08A 3rr3D-1hpgA:
0.0		 3rr3D-1hpgA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 HIS A  57
ASP A 102
GLY A 193
ALA A 226
SER A 225
 None
 0.95A 3sudA-1hpgA:
11.1		 3sudA-1hpgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 HIS A  57
ASP A 102
GLY A 193
ALA A 226
SER A 225
 None
 1.00A 3sudD-1hpgA:
11.1		 3sudD-1hpgA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		3 / 3 SER A  43
ASP A 102
ASP A 173
 None
 0.90A 4mwzA-1hpgA:
undetectable		 4mwzA-1hpgA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 10 VAL A  48
VAL A 231
LEU A 235
GLY A 197
ALA A  45
 None
 1.03A 4ph9A-1hpgA:
undetectable		 4ph9A-1hpgA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 10 VAL A  48
VAL A 231
LEU A 235
GLY A 197
ALA A  45
 None
 1.01A 4ph9B-1hpgA:
undetectable		 4ph9B-1hpgA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 11 HIS A 213
SER A 195
GLY A 104
ALA A  55
THR A  59
 None
 1.32A 4qvpV-1hpgA:
undetectable
4qvpb-1hpgA:
undetectable		 4qvpV-1hpgA:
21.07
4qvpb-1hpgA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 11 HIS A 213
SER A 195
GLY A 104
ALA A  55
THR A  59
 None
 1.32A 4qvpH-1hpgA:
undetectable
4qvpN-1hpgA:
undetectable		 4qvpH-1hpgA:
21.07
4qvpN-1hpgA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 11 HIS A 213
SER A 195
GLY A 104
ALA A  55
THR A  59
 None
 1.44A 5bxnV-1hpgA:
undetectable
5bxnb-1hpgA:
undetectable		 5bxnV-1hpgA:
21.95
5bxnb-1hpgA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 11 HIS A 213
SER A 195
GLY A 104
ALA A  55
THR A  59
 None
 1.43A 5bxnH-1hpgA:
undetectable
5bxnN-1hpgA:
undetectable		 5bxnH-1hpgA:
21.95
5bxnN-1hpgA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 11 THR A 117
GLN A 122
ALA A  44
GLY A  19
ALA A 198
 None
 1.03A 5bxnV-1hpgA:
undetectable
5bxnW-1hpgA:
undetectable		 5bxnV-1hpgA:
21.95
5bxnW-1hpgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 10 ILE A  31
GLY A 104
SER A 195
GLY A 197
VAL A 106
 None
 1.19A 5i6xA-1hpgA:
undetectable		 5i6xA-1hpgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 ILE A  31
ALA A  30
SER A  40
GLY A  86
VAL A 106
 None
 1.19A 5i75A-1hpgA:
undetectable		 5i75A-1hpgA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 THR A 117
GLN A 122
ALA A  44
GLY A  19
ALA A 198
 None
 1.28A 5l5zH-1hpgA:
0.0
5l5zI-1hpgA:
undetectable		 5l5zH-1hpgA:
21.07
5l5zI-1hpgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 HIS A 213
SER A 195
GLY A 104
ALA A  55
THR A  59
 None
 1.33A 5l5zH-1hpgA:
undetectable
5l5zN-1hpgA:
undetectable		 5l5zH-1hpgA:
21.07
5l5zN-1hpgA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		5 / 12 THR A 117
GLN A 122
ALA A  44
GLY A  19
ALA A 198
 None
 1.33A 5l5zV-1hpgA:
undetectable
5l5zW-1hpgA:
undetectable		 5l5zV-1hpgA:
21.07
5l5zW-1hpgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		4 / 8 HIS A 213
HIS A 199
THR A 183
ALA A 190
 None
 0.85A 5tt3H-1hpgA:
undetectable		 5tt3H-1hpgA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		4 / 8 HIS A 228
PHE A 200
SER A 159
LEU A 120
 None
 1.07A 5y2tB-1hpgA:
undetectable		 5y2tB-1hpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		4 / 5 ALA A  30
SER A  43
GLY A 140
TYR A 120
 None
 1.16A 5yodB-1hpgA:
9.8		 5yodB-1hpgA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 1hpg GLUTAMIC ACID
SPECIFIC PROTEASE
(Streptomyces
griseus) 		4 / 5 ALA A  30
SER A  43
GLY A 140
TYR A 120
 None
 1.07A 5yodD-1hpgA:
10.1		 5yodD-1hpgA:
24.37