SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1hpl LIPASE
(Equus
caballus) 		4 / 7 VAL A 438
LEU A 443
LEU A 444
PHE A 400
 None
 0.85A 1j8uA-1hplA:
undetectable		 1j8uA-1hplA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1hpl LIPASE
(Equus
caballus) 		3 / 3 ARG A 439
ILE A 401
TRP A 402
 None
 1.11A 1nodB-1hplA:
0.3		 1nodB-1hplA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 1hpl LIPASE
(Equus
caballus) 		3 / 3 ARG A 439
ILE A 401
TRP A 402
 None
 1.12A 1qomA-1hplA:
0.2		 1qomA-1hplA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 1hpl LIPASE
(Equus
caballus) 		4 / 7 ALA A 161
VAL A 124
GLY A 150
ILE A 149
 None
 0.80A 1t7jB-1hplA:
undetectable		 1t7jB-1hplA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1hpl LIPASE
(Equus
caballus) 		5 / 12 TYR A 270
GLY A 174
ALA A 196
ILE A  74
HIS A 147
 None
 1.10A 1ve3A-1hplA:
undetectable		 1ve3A-1hplA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 1hpl LIPASE
(Equus
caballus) 		5 / 12 TYR A 270
GLY A 174
ALA A 196
ILE A  74
HIS A 147
 None
 1.16A 1ve3B-1hplA:
undetectable		 1ve3B-1hplA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1hpl LIPASE
(Equus
caballus) 		5 / 12 GLY A 174
TYR A 267
SER A 266
VAL A 199
ALA A 221
 None
 1.29A 2avdA-1hplA:
2.1		 2avdA-1hplA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1hpl LIPASE
(Equus
caballus) 		3 / 3 GLY A 393
GLU A 391
ASP A 394
 None
 0.58A 2b25B-1hplA:
undetectable		 2b25B-1hplA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1hpl LIPASE
(Equus
caballus) 		4 / 7 GLY A 282
SER A 300
PHE A 325
GLU A 302
 None
 1.01A 2c8aB-1hplA:
undetectable		 2c8aB-1hplA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1hpl LIPASE
(Equus
caballus) 		4 / 7 GLY A 282
SER A 300
PHE A 325
GLU A 302
 None
 0.98A 2c8aD-1hplA:
undetectable		 2c8aD-1hplA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1hpl LIPASE
(Equus
caballus) 		4 / 6 LEU A 135
VAL A  34
VAL A 104
ARG A 122
 None
 1.03A 2hyyA-1hplA:
undetectable		 2hyyA-1hplA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 1hpl LIPASE
(Equus
caballus) 		5 / 12 LEU A 264
MET A 234
ILE A 206
GLY A 231
HIS A 203
 None
 0.99A 2j7xA-1hplA:
undetectable		 2j7xA-1hplA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 1hpl LIPASE
(Equus
caballus) 		4 / 6 ARG A 164
GLY A 125
PRO A  31
THR A  36
 None
 1.15A 2m2oB-1hplA:
undetectable		 2m2oB-1hplA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 1hpl LIPASE
(Equus
caballus) 		3 / 3 ARG A 439
ILE A 401
TRP A 402
 None
 1.12A 2nodB-1hplA:
0.3		 2nodB-1hplA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1hpl LIPASE
(Equus
caballus) 		4 / 7 TYR A 270
PRO A 305
LEU A 224
PHE A 198
 None
 1.14A 2vcvA-1hplA:
0.0		 2vcvA-1hplA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1hpl LIPASE
(Equus
caballus) 		5 / 12 GLY A 174
HIS A 151
LEU A 224
MET A 307
LEU A 327
 None
 1.20A 3bxoA-1hplA:
undetectable		 3bxoA-1hplA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1hpl LIPASE
(Equus
caballus) 		4 / 8 LYS A 268
ARG A 337
MET A 234
GLU A  82
 None
 1.10A 3dh0A-1hplA:
2.1		 3dh0A-1hplA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hpl LIPASE
(Equus
caballus) 		3 / 3 ARG A 439
ILE A 401
TRP A 402
 None
 1.13A 3e7iB-1hplA:
0.0		 3e7iB-1hplA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 1hpl LIPASE
(Equus
caballus) 		4 / 6 ASN A 100
ARG A  68
ASN A  63
GLU A  44
 None
 1.10A 3galA-1hplA:
undetectable		 3galA-1hplA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 1hpl LIPASE
(Equus
caballus) 		5 / 9 VAL A 104
PHE A  38
ILE A  74
ALA A 126
VAL A  34
 None
 1.07A 3me6C-1hplA:
0.0		 3me6C-1hplA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 1hpl LIPASE
(Equus
caballus) 		5 / 9 GLY A   9
ARG A 164
GLU A   2
LEU A   8
ILE A 123
 None
 1.35A 3nbqA-1hplA:
3.2		 3nbqA-1hplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1hpl LIPASE
(Equus
caballus) 		3 / 3 ARG A 439
ILE A 401
TRP A 402
 None
 1.10A 3nw2B-1hplA:
0.3		 3nw2B-1hplA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 1hpl LIPASE
(Equus
caballus) 		5 / 10 ALA A 161
VAL A 124
GLY A 150
ILE A 149
VAL A 128
 None
 0.98A 3t3cB-1hplA:
undetectable		 3t3cB-1hplA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1hpl LIPASE
(Equus
caballus) 		5 / 12 LEU A  86
GLY A 154
LEU A 153
SER A 110
PHE A 215
 None
 1.24A 3tbgA-1hplA:
undetectable		 3tbgA-1hplA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hpl LIPASE
(Equus
caballus) 		5 / 12 PHE A 139
SER A  62
LEU A 131
VAL A 132
PHE A  72
 None
 1.33A 3u9fP-1hplA:
0.0
3u9fS-1hplA:
0.0		 3u9fP-1hplA:
19.29
3u9fS-1hplA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1hpl LIPASE
(Equus
caballus) 		3 / 3 PHE A 314
SER A 284
SER A 300
 None
 0.92A 3ufgB-1hplA:
0.0		 3ufgB-1hplA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 1hpl LIPASE
(Equus
caballus) 		5 / 12 ASP A 225
HIS A 156
ASP A 176
HIS A 203
GLY A 216
 None
 1.43A 4bz6A-1hplA:
undetectable
4bz6B-1hplA:
undetectable		 4bz6A-1hplA:
22.76
4bz6B-1hplA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1hpl LIPASE
(Equus
caballus) 		4 / 8 GLN A 306
ASN A 425
TRP A 338
THR A 329
 None
 1.39A 4d1yA-1hplA:
2.4
4d1yB-1hplA:
2.4		 4d1yA-1hplA:
19.81
4d1yB-1hplA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 1hpl LIPASE
(Equus
caballus) 		5 / 12 LEU A 264
MET A 234
ILE A 206
GLY A 231
HIS A 203
 None
 0.97A 4j26A-1hplA:
undetectable		 4j26A-1hplA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1hpl LIPASE
(Equus
caballus) 		3 / 3 HIS A 151
TRP A 106
SER A 266
 None
 1.15A 4lrhD-1hplA:
0.0		 4lrhD-1hplA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1hpl LIPASE
(Equus
caballus) 		3 / 3 MET A 234
ASP A 176
PHE A 215
 None
 1.07A 4xeyB-1hplA:
0.0		 4xeyB-1hplA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1hpl LIPASE
(Equus
caballus) 		3 / 3 ASP A 331
ASN A 328
PHE A 386
 None
 0.64A 5dsgB-1hplA:
0.0		 5dsgB-1hplA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1hpl LIPASE
(Equus
caballus) 		5 / 12 ASP A 225
HIS A 223
ARG A 171
ARG A 190
LEU A 191
 None
 1.40A 5nd2B-1hplA:
4.3		 5nd2B-1hplA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B8K_A_W9TA300_0
(GALECTIN-3)		 1hpl LIPASE
(Equus
caballus) 		4 / 7 ASN A 100
ARG A  68
ASN A  63
GLU A  44
 None
 1.11A 6b8kA-1hplA:
undetectable		 6b8kA-1hplA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1hpl LIPASE
(Equus
caballus) 		5 / 9 VAL A 398
VAL A 355
LEU A 446
GLY A 416
LEU A 444
 None
 1.35A 6czmD-1hplA:
0.0
6czmE-1hplA:
0.1		 6czmD-1hplA:
23.03
6czmE-1hplA:
23.03