SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hqk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		7 / 12 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
ILE A  92
 None
 0.56A 1kyvA-1hqkA:
24.3
1kyvE-1hqkA:
23.9		 1kyvA-1hqkA:
37.89
1kyvE-1hqkA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_B_RBFB502_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		6 / 11 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
 None
 0.27A 1kyvA-1hqkA:
24.3
1kyvB-1hqkA:
24.3		 1kyvA-1hqkA:
37.89
1kyvB-1hqkA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		7 / 12 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
ILE A  92
 None
 0.56A 1kyvB-1hqkA:
24.3
1kyvC-1hqkA:
24.2		 1kyvB-1hqkA:
37.89
1kyvC-1hqkA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		7 / 12 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
ILE A  92
 None
 0.56A 1kyvC-1hqkA:
24.2
1kyvD-1hqkA:
24.3		 1kyvC-1hqkA:
37.89
1kyvD-1hqkA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		7 / 12 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
ILE A  92
 None
 0.53A 1kyvD-1hqkA:
24.3
1kyvE-1hqkA:
23.9		 1kyvD-1hqkA:
37.89
1kyvE-1hqkA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A58_A_RBFA300_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		6 / 11 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
 None
 0.28A 2a58A-1hqkA:
24.3
2a58E-1hqkA:
24.3		 2a58A-1hqkA:
37.89
2a58E-1hqkA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		6 / 12 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
 None
 0.27A 2a58A-1hqkA:
24.3
2a58B-1hqkA:
24.2		 2a58A-1hqkA:
37.89
2a58B-1hqkA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		6 / 12 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
 None
 0.27A 2a58B-1hqkA:
24.2
2a58C-1hqkA:
24.2		 2a58B-1hqkA:
37.89
2a58C-1hqkA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A58_D_RBFD303_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		6 / 11 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
 None
 0.27A 2a58C-1hqkA:
24.2
2a58D-1hqkA:
24.3		 2a58C-1hqkA:
37.89
2a58D-1hqkA:
37.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		6 / 12 GLY A  55
SER A  56
TRP A  57
GLU A  58
LEU A  81
HIS A  88
 None
 0.28A 2a58D-1hqkA:
24.3
2a58E-1hqkA:
24.3		 2a58D-1hqkA:
37.89
2a58E-1hqkA:
37.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 LEU A  50
ALA A  34
GLY A 114
VAL A 115
ILE A  17
 None
 1.19A 2o4lA-1hqkA:
undetectable		 2o4lA-1hqkA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		5 / 12 ALA A 143
ILE A 111
GLY A 114
ILE A  78
LEU A  66
 None
 1.00A 2o4nA-1hqkA:
undetectable		 2o4nA-1hqkA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 ILE A  72
ARG A  68
LEU A 107
LEU A 103
 None
 0.71A 2vctA-1hqkA:
0.0		 2vctA-1hqkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 GLY A  99
GLU A  95
ILE A  59
ALA A  63
 None
 0.93A 3aodA-1hqkA:
0.0		 3aodA-1hqkA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		5 / 11 LEU A  50
ALA A  34
GLY A 114
VAL A 115
ILE A  17
 None
 1.29A 3oxxB-1hqkA:
undetectable		 3oxxB-1hqkA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		4 / 8 LEU A 100
LEU A 103
LEU A 107
ILE A  59
 None
 0.86A 4klaA-1hqkA:
2.1		 4klaA-1hqkA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		4 / 6 PHE A  22
LEU A  26
SER A  20
GLY A  79
 None
 1.13A 5o4yF-1hqkA:
undetectable		 5o4yF-1hqkA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Aquifex
aeolicus) 		3 / 3 ARG A 127
LYS A 135
ARG A  40
 None
 1.25A 6c06D-1hqkA:
0.0		 6c06D-1hqkA:
undetectable