SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hqm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GSE_B_EAAB224_1 (GLUTATHIONE TRANSFERASE)	1hqm	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus aquaticus)	5 / 12	GLY A 37 LEU A 194 LEU A 25 LEU A 210 ALA A 213	None	1.02A	1gseB-1hqmA: undetectable	1gseB-1hqmA: 24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OUB_A_2TNA134_1 (PHOSPHOLIPASE A2 VRV-PL-VIIIA)	1hqm	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus aquaticus)	4 / 4	LEU A 131 ILE A 68 HIS A 127 LYS A 106	None	1.32A	2oubA-1hqmA: 0.0	2oubA-1hqmA: 15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD3_A_CHDA502_0 (FERROCHELATASE)	1hqm	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus aquaticus)	4 / 8	PRO A 172 SER A 203 VAL A 147 GLY A 146	None	0.89A	2qd3A-1hqmA: undetectable	2qd3A-1hqmA: 22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YGP_A_PCFA1213_0 (WNT INHIBITORY FACTOR 1)	1hqm	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus aquaticus)	5 / 12	ILE A 58 LEU A 137 ILE A 164 PHE A 113 VAL A 53	None	1.08A	2ygpA-1hqmA: undetectable	2ygpA-1hqmA: 16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PHN_A_ACTA108_0 (PROTEIN P-30)	1hqm	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus aquaticus)	3 / 3	THR A 54 SER A 55 ARG A 142	None	0.67A	3phnA-1hqmA: 0.0	3phnA-1hqmA: 13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W68_C_VIVC301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	1hqm	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus aquaticus)	5 / 12	VAL A 143 ILE A 68 ILE A 78 LEU A 82 VAL A 53	None	1.26A	3w68C-1hqmA: undetectable	3w68C-1hqmA: 22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L66_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6)	1hqm	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus aquaticus)	5 / 10	ALA A 129 THR A 130 GLY A 135 ALA A 102 ASP A 112	None	1.26A	5l66K-1hqmA: undetectable 5l66L-1hqmA: undetectable	5l66K-1hqmA: 21.59 5l66L-1hqmA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L66_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6)	1hqm	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus aquaticus)	5 / 10	ALA A 129 THR A 130 GLY A 135 ALA A 102 ASP A 112	None	1.26A	5l66Y-1hqmA: undetectable 5l66Z-1hqmA: undetectable	5l66Y-1hqmA: 21.59 5l66Z-1hqmA: 21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_B_GMJB301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	1hqm	DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA (Thermus aquaticus)	4 / 6	ASP A 201 GLN A 212 VAL A 204 ALA A 177	None	0.97A	6djzB-1hqmA: undetectable	6djzB-1hqmA: 22.05

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GSE_B_EAAB224_1","GLUTATHIONE TRANSFERASE","1hqm","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus aquaticus",5,"GLY A  37;LEU A 194;LEU A  25;LEU A 210;ALA A 213","None","1.02A","1gseB-1hqmA:undetectable","1gseB-1hqmA:24.62"],["2OUB_A_2TNA134_1","PHOSPHOLIPASE A2 VRV-PL-VIIIA","1hqm","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus aquaticus",4,"LEU A 131;ILE A  68;HIS A 127;LYS A 106","None","1.32A","2oubA-1hqmA:0.0","2oubA-1hqmA:15.65"],["2QD3_A_CHDA502_0","FERROCHELATASE","1hqm","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus aquaticus",4,"PRO A 172;SER A 203;VAL A 147;GLY A 146","None","0.89A","2qd3A-1hqmA:undetectable","2qd3A-1hqmA:22.82"],["2YGP_A_PCFA1213_0","WNT INHIBITORY FACTOR 1","1hqm","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus aquaticus",5,"ILE A  58;LEU A 137;ILE A 164;PHE A 113;VAL A  53","None","1.08A","2ygpA-1hqmA:undetectable","2ygpA-1hqmA:16.67"],["3PHN_A_ACTA108_0","PROTEIN P-30","1hqm","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus aquaticus",3,"THR A  54;SER A  55;ARG A 142","None","0.67A","3phnA-1hqmA:0.0","3phnA-1hqmA:13.50"],["3W68_C_VIVC301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","1hqm","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus aquaticus",5,"VAL A 143;ILE A  68;ILE A  78;LEU A  82;VAL A  53","None","1.26A","3w68C-1hqmA:undetectable","3w68C-1hqmA:22.42"],["5L66_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6","1hqm","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus aquaticus",5,"ALA A 129;THR A 130;GLY A 135;ALA A 102;ASP A 112","None","1.26A","5l66K-1hqmA:undetectable;5l66L-1hqmA:undetectable","5l66K-1hqmA:21.59;5l66L-1hqmA:21.30"],["5L66_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-8,PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6,PROTEASOME SUBUNIT BETA TYPE-1,PROTEASOME SUBUNIT BETA TYPE-6","1hqm","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus aquaticus",5,"ALA A 129;THR A 130;GLY A 135;ALA A 102;ASP A 112","None","1.26A","5l66Y-1hqmA:undetectable;5l66Z-1hqmA:undetectable","5l66Y-1hqmA:21.59;5l66Z-1hqmA:21.30"],["6DJZ_B_GMJB301_1","SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1","1hqm","DNA-DIRECTED RNA POLYMERASE SUBUNIT ALPHA","Thermus aquaticus",4,"ASP A 201;GLN A 212;VAL A 204;ALA A 177","None","0.97A","6djzB-1hqmA:undetectable","6djzB-1hqmA:22.05"]]