SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hqo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 212
TRP A 202
ASP A 204
PRO A 199
 None
 1.16A 1ditH-1hqoA:
0.0
1ditP-1hqoA:
undetectable		 1ditH-1hqoA:
21.50
1ditP-1hqoA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 125
PRO A 123
SER A 118
HIS A 119
 None
 0.93A 1gxsA-1hqoA:
undetectable
1gxsB-1hqoA:
0.6		 1gxsA-1hqoA:
21.64
1gxsB-1hqoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 159
ALA A 167
LEU A 144
PHE A 117
 None
 1.07A 1q97B-1hqoA:
undetectable		 1q97B-1hqoA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 185
LEU A 201
ILE A 130
ARG A 344
LEU A 168
 None
 1.27A 1tw4B-1hqoA:
0.0		 1tw4B-1hqoA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.03A 1zzrA-1hqoA:
0.0
1zzrB-1hqoA:
0.0		 1zzrA-1hqoA:
19.28
1zzrB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 0.99A 1zzrA-1hqoA:
0.0
1zzrB-1hqoA:
0.0		 1zzrA-1hqoA:
19.28
1zzrB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.05A 1zzuA-1hqoA:
0.6
1zzuB-1hqoA:
0.0		 1zzuA-1hqoA:
19.28
1zzuB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.05A 1zzuA-1hqoA:
0.6
1zzuB-1hqoA:
0.0		 1zzuA-1hqoA:
19.28
1zzuB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.03A 3dqrA-1hqoA:
0.0
3dqrB-1hqoA:
0.0		 3dqrA-1hqoA:
19.28
3dqrB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.11A 3dqrA-1hqoA:
0.0
3dqrB-1hqoA:
0.0		 3dqrA-1hqoA:
19.28
3dqrB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.01A 3jx2A-1hqoA:
0.0
3jx2B-1hqoA:
0.0		 3jx2A-1hqoA:
19.28
3jx2B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.02A 3jx2A-1hqoA:
0.0
3jx2B-1hqoA:
0.0		 3jx2A-1hqoA:
19.28
3jx2B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.04A 3jx3A-1hqoA:
0.4
3jx3B-1hqoA:
0.5		 3jx3A-1hqoA:
19.28
3jx3B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.07A 3jx3A-1hqoA:
0.4
3jx3B-1hqoA:
0.5		 3jx3A-1hqoA:
19.28
3jx3B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.00A 3jx4A-1hqoA:
undetectable
3jx4B-1hqoA:
undetectable		 3jx4A-1hqoA:
19.28
3jx4B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.00A 3jx5A-1hqoA:
0.0
3jx5B-1hqoA:
0.5		 3jx5A-1hqoA:
19.28
3jx5B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.05A 3jx5A-1hqoA:
0.0
3jx5B-1hqoA:
0.5		 3jx5A-1hqoA:
19.28
3jx5B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.08A 3jx6A-1hqoA:
0.4
3jx6B-1hqoA:
0.4		 3jx6A-1hqoA:
19.28
3jx6B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.10A 3jx6A-1hqoA:
0.4
3jx6B-1hqoA:
0.4		 3jx6A-1hqoA:
19.28
3jx6B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.04A 3n61A-1hqoA:
0.5
3n61B-1hqoA:
0.5		 3n61A-1hqoA:
19.28
3n61B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.01A 3n61A-1hqoA:
0.5
3n61B-1hqoA:
0.5		 3n61A-1hqoA:
19.28
3n61B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.05A 3nljA-1hqoA:
0.5
3nljB-1hqoA:
0.9		 3nljA-1hqoA:
19.28
3nljB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.09A 3nljA-1hqoA:
0.5
3nljB-1hqoA:
0.9		 3nljA-1hqoA:
19.28
3nljB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.01A 3nlpA-1hqoA:
0.0
3nlpB-1hqoA:
0.5		 3nlpA-1hqoA:
19.28
3nlpB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.05A 3nlpA-1hqoA:
0.0
3nlpB-1hqoA:
0.5		 3nlpA-1hqoA:
19.28
3nlpB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 0.99A 3nlqA-1hqoA:
0.0
3nlqB-1hqoA:
0.0		 3nlqA-1hqoA:
19.28
3nlqB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 0.99A 3nlqA-1hqoA:
0.0
3nlqB-1hqoA:
0.0		 3nlqA-1hqoA:
19.28
3nlqB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.00A 3nlrA-1hqoA:
0.0
3nlrB-1hqoA:
0.5		 3nlrA-1hqoA:
19.28
3nlrB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.06A 3nlrA-1hqoA:
0.0
3nlrB-1hqoA:
0.5		 3nlrA-1hqoA:
19.28
3nlrB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.07A 4cx3A-1hqoA:
0.4
4cx3B-1hqoA:
0.0		 4cx3A-1hqoA:
19.28
4cx3B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.02A 4cx3A-1hqoA:
0.4
4cx3B-1hqoA:
0.0		 4cx3A-1hqoA:
19.28
4cx3B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.08A 4cx4A-1hqoA:
1.0
4cx4B-1hqoA:
0.0		 4cx4A-1hqoA:
19.28
4cx4B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.08A 4cx4A-1hqoA:
1.0
4cx4B-1hqoA:
0.0		 4cx4A-1hqoA:
19.28
4cx4B-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 256
HIS A 223
ASP A 321
TYR A 235
 None
 1.42A 4qdjA-1hqoA:
undetectable		 4qdjA-1hqoA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 0.99A 5addA-1hqoA:
0.0
5addB-1hqoA:
0.9		 5addA-1hqoA:
19.28
5addB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.04A 5adeA-1hqoA:
0.0
5adeB-1hqoA:
0.8		 5adeA-1hqoA:
19.28
5adeB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 334
VAL A 299
TRP A 337
GLU A 260
 None
 1.06A 5g0pA-1hqoA:
0.0
5g0pB-1hqoA:
0.0		 5g0pA-1hqoA:
19.28
5g0pB-1hqoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1hqo URE2 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 260
VAL A 334
VAL A 299
TRP A 337
 None
 1.02A 5g0pA-1hqoA:
0.0
5g0pB-1hqoA:
0.0		 5g0pA-1hqoA:
19.28
5g0pB-1hqoA:
19.28