SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hqr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		4 / 8 TYR D 585
TYR D 524
ARG D 545
VAL D 571
 None
 0.95A 2fl5E-1hqrD:
undetectable
2fl5F-1hqrD:
undetectable		 2fl5E-1hqrD:
20.44
2fl5F-1hqrD:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		4 / 6 ILE D 693
PHE D 563
GLY D 589
GLY D 588
 None
 0.84A 2qx6A-1hqrD:
undetectable
2qx6B-1hqrD:
undetectable		 2qx6A-1hqrD:
19.43
2qx6B-1hqrD:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		4 / 8 ALA D 559
GLN D 630
TYR D 688
ILE D 670
 None
 0.94A 3cldB-1hqrD:
0.0		 3cldB-1hqrD:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		3 / 3 ASN D 605
MET D 696
PHE D 702
 None
 1.09A 3g4lD-1hqrD:
undetectable		 3g4lD-1hqrD:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		3 / 3 SER D 675
GLY D 679
SER D 511
 None
 0.63A 3loqA-1hqrD:
undetectable		 3loqA-1hqrD:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4jksA-1hqrD:
undetectable		 4jksA-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4jksB-1hqrD:
undetectable		 4jksB-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.98A 4jkuA-1hqrD:
undetectable		 4jkuA-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4k8cA-1hqrD:
undetectable		 4k8cA-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.98A 4k8cB-1hqrD:
undetectable		 4k8cB-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4k8kA-1hqrD:
undetectable		 4k8kA-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4k8kB-1hqrD:
undetectable		 4k8kB-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4kahA-1hqrD:
undetectable		 4kahA-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4kahB-1hqrD:
undetectable		 4kahB-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.98A 4kalA-1hqrD:
undetectable		 4kalA-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4kalB-1hqrD:
undetectable		 4kalB-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4kanA-1hqrD:
undetectable		 4kanA-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4kanB-1hqrD:
undetectable		 4kanB-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 1.00A 4kbeA-1hqrD:
undetectable		 4kbeA-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4kbeB-1hqrD:
undetectable		 4kbeB-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4lbgA-1hqrD:
undetectable		 4lbgA-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4lbgB-1hqrD:
undetectable		 4lbgB-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.99A 4lcaA-1hqrD:
undetectable		 4lcaA-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		5 / 12 ILE D 586
GLY D 589
GLY D 588
ASN D 691
ILE D 539
 None
 0.98A 4lcaB-1hqrD:
undetectable		 4lcaB-1hqrD:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		3 / 3 PHE D 702
ILE D 704
ASP D 671
 None
 0.53A 5cswA-1hqrD:
undetectable		 5cswA-1hqrD:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		3 / 3 PHE D 702
ILE D 704
ASP D 671
 None
 0.47A 5cswB-1hqrD:
undetectable		 5cswB-1hqrD:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1hqr STREPTOCOCCAL
PYROGENIC EXOTOXIN C
(Streptococcus
pyogenes) 		4 / 8 ILE D 694
THR D 662
GLU D 668
HIS D 667
 None
None
None
ZN  D 709 (-3.2A)
 0.89A 5ecnD-1hqrD:
undetectable		 5ecnD-1hqrD:
15.55