SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hqs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 GLY A 310
ALA A 286
THR A 305
ILE A 313
 None
 0.71A 1gtnP-1hqsA:
undetectable
1gtnQ-1hqsA:
undetectable		 1gtnP-1hqsA:
11.90
1gtnQ-1hqsA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 7 THR A 305
SER A 215
THR A 217
VAL A 219
 None
 0.65A 1ictD-1hqsA:
undetectable		 1ictD-1hqsA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHV_A_NOGA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 SER A 385
THR A 396
ASP A 398
LEU A 418
 None
 1.11A 1lhvA-1hqsA:
undetectable		 1lhvA-1hqsA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 VAL A 176
GLN A 171
LEU A 166
ILE A 167
SER A 185
 None
 1.13A 2fj1A-1hqsA:
undetectable		 2fj1A-1hqsA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 ALA A  44
GLY A 415
SER A 385
 None
 0.57A 2ivuA-1hqsA:
undetectable		 2ivuA-1hqsA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 9 ILE A  34
ALA A 352
CYH A 411
LYS A 410
 None
 0.76A 2vufB-1hqsA:
undetectable		 2vufB-1hqsA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 9 ILE A  34
VAL A 357
CYH A 411
LYS A 410
 None
 0.98A 2vufB-1hqsA:
undetectable		 2vufB-1hqsA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 7 VAL A  41
LEU A  42
SER A  39
VAL A 362
 None
 0.92A 3hs6B-1hqsA:
0.0		 3hs6B-1hqsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 GLU A 377
LEU A 381
LEU A 368
 None
 0.76A 3ohtA-1hqsA:
undetectable		 3ohtA-1hqsA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 THR A 305
SER A 215
THR A 217
VAL A 219
 None
 0.63A 4ik7B-1hqsA:
undetectable		 4ik7B-1hqsA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 5 ILE A 383
VAL A 367
ILE A 363
VAL A 382
 PGO  A 902 ( 4.3A)
None
None
None
 0.74A 4xdtA-1hqsA:
0.0		 4xdtA-1hqsA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 10 TYR A 124
PHE A 399
SER A 130
GLY A 322
VAL A 395
 None
 1.20A 5i6xA-1hqsA:
0.0		 5i6xA-1hqsA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 MET A 386
ILE A 390
ALA A  38
VAL A  41
THR A  30
 None
 1.34A 5igpA-1hqsA:
0.0		 5igpA-1hqsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 12 GLY A 159
SER A 160
LYS A 158
LEU A 166
GLU A 162
 None
 1.30A 5nwvA-1hqsA:
0.0		 5nwvA-1hqsA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 8 LEU A  42
VAL A 367
LEU A 418
ILE A 383
 None
None
None
PGO  A 902 ( 4.3A)
 1.02A 5v0vA-1hqsA:
undetectable		 5v0vA-1hqsA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		4 / 9 VAL A 107
VAL A 192
SER A 193
ASP A 149
 None
 0.97A 6c2mD-1hqsA:
undetectable		 6c2mD-1hqsA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		5 / 9 LEU A 109
ILE A  25
PRO A  23
VAL A  61
ILE A  83
 None
 1.07A 6ef6A-1hqsA:
undetectable		 6ef6A-1hqsA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 TRP A 235
GLU A 195
GLU A 148
 None
 1.02A 6fhwA-1hqsA:
undetectable		 6fhwA-1hqsA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 ASN A 298
PRO A 297
GLN A 292
 None
 0.91A 6jnhA-1hqsA:
2.1		 6jnhA-1hqsA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1hqs ISOCITRATE
DEHYDROGENASE
(Bacillus
subtilis) 		3 / 3 ASN A 298
PRO A 297
GLN A 292
 None
 0.91A 6jogA-1hqsA:
0.9		 6jogA-1hqsA:
18.63