SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1hr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 GLY B  67
ALA B  60
THR B  68
THR B 103
ALA B  56
 None
 1.46A 1gtnO-1hr7B:
undetectable
1gtnP-1hr7B:
undetectable		 1gtnO-1hr7B:
9.26
1gtnP-1hr7B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 GLY B  67
ALA B  60
THR B  68
THR B 103
ALA B  56
 None
 1.47A 1gtnQ-1hr7B:
undetectable
1gtnR-1hr7B:
undetectable		 1gtnQ-1hr7B:
9.26
1gtnR-1hr7B:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 PRO B  43
THR A  35
PRO A  36
GLY A  37
 None
 0.70A 1h4oB-1hr7B:
undetectable		 1h4oB-1hr7B:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 PRO B  43
THR A  35
PRO A  36
GLY A  37
 None
 0.76A 1h4oG-1hr7B:
undetectable		 1h4oG-1hr7B:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 110
LEU A  86
LEU A  87
 None
 0.78A 1ikeA-1hr7A:
0.0		 1ikeA-1hr7A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 GLY B 182
GLY B  67
ASN B  66
THR B 103
TYR B 198
 None
 1.17A 1likA-1hr7B:
undetectable		 1likA-1hr7B:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 169
THR A 167
ALA A 161
SER A 164
GLY A 327
 None
 1.25A 1nbiC-1hr7A:
0.0		 1nbiC-1hr7A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 169
THR A 167
ALA A 161
SER A 164
GLY A 327
 None
 1.25A 1nbiD-1hr7A:
0.0		 1nbiD-1hr7A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 8 PRO B  43
THR A  35
PRO A  36
GLY A  37
 None
 0.72A 1oc3A-1hr7B:
undetectable		 1oc3A-1hr7B:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 120
THR A 121
LEU A  84
 None
 0.71A 1v8bC-1hr7A:
undetectable		 1v8bC-1hr7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 PHE B 326
LEU B 176
SER B 440
MET B 441
 None
 1.17A 1wrlE-1hr7B:
undetectable		 1wrlE-1hr7B:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 PHE B  71
ARG B 178
ASN B  65
 None
 0.91A 1xzxX-1hr7B:
0.0		 1xzxX-1hr7B:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 362
LEU A 282
ASP A 365
ARG A 301
 None
 0.56A 2j2pA-1hr7A:
0.0
2j2pB-1hr7A:
0.0		 2j2pA-1hr7A:
19.10
2j2pB-1hr7A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_B_FOLB1188_0
(DIHYDROFOLATE
REDUCTASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 331
ALA A 348
LEU A 460
PHE A 263
LEU A 158
 None
 1.30A 2w3mB-1hr7A:
undetectable		 2w3mB-1hr7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASN B  62
VAL B  63
GLY B 182
ILE B 147
SER B 151
 None
 1.21A 3bwmA-1hr7B:
undetectable		 3bwmA-1hr7B:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU A  84
GLY A  89
ASN B 374
TYR A  91
ASN B 304
 None
 1.12A 3eeoA-1hr7A:
undetectable		 3eeoA-1hr7A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 423
LEU A 360
ILE A 273
ILE A 427
 None
 0.83A 3gcsA-1hr7A:
undetectable		 3gcsA-1hr7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 VAL B 395
ILE B 119
VAL B 123
GLY B  51
 None
 0.77A 3hjoB-1hr7B:
0.0		 3hjoB-1hr7B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ARG B 245
TYR B 203
ASP B  55
LEU B 241
LEU B  31
 None
 1.36A 3lcvB-1hr7B:
undetectable		 3lcvB-1hr7B:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PHE B 163
GLY B 337
ALA B 271
THR B 170
ILE B 258
 None
 1.17A 3ld6A-1hr7B:
0.0		 3ld6A-1hr7B:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 TYR B 110
MET B 208
LEU B  35
LEU B 130
 None
 1.14A 3nk2X-1hr7B:
0.0		 3nk2X-1hr7B:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ILE B 352
ILE B 356
VAL B 349
ILE B 270
ILE B 268
 None
 1.17A 3p4wB-1hr7B:
0.0		 3p4wB-1hr7B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 TYR B 455
ILE B 456
MET B 441
VAL B 353
ILE B 268
 None
 1.21A 3p4wB-1hr7B:
0.0		 3p4wB-1hr7B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ILE B 352
ILE B 356
VAL B 349
ILE B 270
ILE B 268
 None
 1.18A 3p4wD-1hr7B:
0.0		 3p4wD-1hr7B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 TYR B 455
ILE B 456
MET B 441
VAL B 353
ILE B 268
 None
 1.20A 3p4wD-1hr7B:
0.0		 3p4wD-1hr7B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ILE B 352
ILE B 356
VAL B 349
ILE B 270
ILE B 268
 None
 1.19A 3p4wE-1hr7B:
0.0		 3p4wE-1hr7B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 TYR B 455
ILE B 456
MET B 441
VAL B 353
ILE B 268
 None
 1.18A 3p4wE-1hr7B:
0.0		 3p4wE-1hr7B:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 403
GLU A 407
ALA A  14
ASN A 406
 None
 1.05A 3pgyA-1hr7A:
undetectable
3pgyB-1hr7A:
undetectable		 3pgyA-1hr7A:
20.44
3pgyB-1hr7A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		3 / 3 HIS B  98
SER B 391
ASN A 381
 None
 0.85A 3s8pB-1hr7B:
0.0		 3s8pB-1hr7B:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 187
ALA A  68
THR A 121
LEU A 100
 None
 1.02A 3t3zD-1hr7A:
undetectable		 3t3zD-1hr7A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 TYR A  45
PHE A 204
SER A  33
VAL A 106
VAL A 207
 None
 1.03A 3u9fI-1hr7A:
0.0		 3u9fI-1hr7A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 TYR A  45
PHE A 204
SER A  33
VAL A 106
VAL A 207
 None
 1.08A 3u9fR-1hr7A:
0.0		 3u9fR-1hr7A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 LEU B 380
VAL B 275
ILE B 368
ILE B 426
PHE B 283
 None
 1.24A 3w68C-1hr7B:
0.4		 3w68C-1hr7B:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 348
VAL A 456
LEU A 460
GLY A 262
PHE A 263
 None
 1.04A 3zosA-1hr7A:
0.0
3zosB-1hr7A:
0.0		 3zosA-1hr7A:
20.12
3zosB-1hr7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 329
ILE A 427
PHE A 428
ALA A 348
GLY A 262
 None
 1.08A 4e1gB-1hr7A:
0.0		 4e1gB-1hr7A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 323
GLN A 260
ARG A  97
LEU A 158
ILE A 328
 None
 1.44A 4k37B-1hr7A:
undetectable		 4k37B-1hr7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 VAL B 439
ALA B 271
PHE B 251
 None
 0.91A 4olbA-1hr7B:
undetectable		 4olbA-1hr7B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ALA B  38
THR B  39
ALA B 211
GLY B  25
ASP B 397
 None
 1.10A 4qvnK-1hr7B:
undetectable
4qvnL-1hr7B:
undetectable		 4qvnK-1hr7B:
19.86
4qvnL-1hr7B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ALA B  38
THR B  39
ALA B 211
GLY B  25
ASP B 397
 None
 1.10A 4qvnY-1hr7B:
undetectable
4qvnZ-1hr7B:
undetectable		 4qvnY-1hr7B:
19.86
4qvnZ-1hr7B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ALA B  38
THR B  39
ALA B 211
GLY B  25
ASP B 397
 None
 1.11A 4qvqK-1hr7B:
undetectable
4qvqL-1hr7B:
undetectable		 4qvqK-1hr7B:
19.59
4qvqL-1hr7B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ALA B  38
THR B  39
ALA B 211
GLY B  25
ASP B 397
 None
 1.11A 4qvqY-1hr7B:
undetectable
4qvqZ-1hr7B:
undetectable		 4qvqY-1hr7B:
19.59
4qvqZ-1hr7B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 GLU B  61
THR B 103
GLY B  57
THR B 108
 None
 0.92A 4qwpB-1hr7B:
0.0		 4qwpB-1hr7B:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ALA B  38
THR B  39
ALA B 211
GLY B  25
ASP B 397
 None
 0.97A 4qwuY-1hr7B:
undetectable
4qwuZ-1hr7B:
undetectable		 4qwuY-1hr7B:
19.35
4qwuZ-1hr7B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 395
HIS A 399
ARG A 401
 None
 1.25A 4qyqB-1hr7A:
undetectable		 4qyqB-1hr7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU B 335
VAL B 162
TYR B 171
ARG B 350
 None
 1.07A 4r7iA-1hr7B:
undetectable		 4r7iA-1hr7B:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 SER A  33
ASP A  47
ASP A 391
 None
 0.79A 4uckA-1hr7A:
undetectable		 4uckA-1hr7A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 SER A  33
ALA A  31
VAL A  30
 None
 0.61A 4x20C-1hr7A:
undetectable		 4x20C-1hr7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 VAL B 439
ALA B 271
PHE B 251
THR B 170
 None
 1.44A 4z4fA-1hr7B:
0.4		 4z4fA-1hr7B:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 VAL B 439
ALA B 271
PHE B 251
THR B 170
 None
 1.41A 4z4hA-1hr7B:
0.0		 4z4hA-1hr7B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  31
PHE A 204
GLY A  43
LEU A 389
ASP A 391
 None
 1.36A 5ajqB-1hr7A:
undetectable		 5ajqB-1hr7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 GLY B  57
ASP B 164
ARG B 178
TYR B 330
 None
 1.07A 5iwuA-1hr7B:
0.0		 5iwuA-1hr7B:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASN B  62
VAL B  63
GLY B 182
ILE B 147
SER B 151
 None
 1.21A 5lsaA-1hr7B:
undetectable		 5lsaA-1hr7B:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 ASN B 202
SER B  58
ALA B  56
VAL B  54
 None
 1.33A 5nm5A-1hr7B:
undetectable		 5nm5A-1hr7B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMM_A_SALA303_0
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 SER B 329
VAL B 275
TYR B 282
LEU B 384
LEU B 380
 None
 1.28A 6emmA-1hr7B:
0.5		 6emmA-1hr7B:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 261
ILE A 331
GLU A 457
VAL A 344
ILE A 347
 None
 1.21A 6hloA-1hr7A:
undetectable		 6hloA-1hr7A:
21.60